11-cis-retinal

11-cis-retinal is a lipid of Prenol Lipids (PR) class. 11-cis-retinal is associated with abnormalities such as Dermatitis, Phototoxic, Retinal Degeneration, Degenerative disorder, Retinal damage and Stargardt's disease. The involved functions are known as chromophore, Pigment, inhibitors, Deterioration and Protective Agents. 11-cis-retinal often locates in Back, Microsomes, Cytoplasmic, Membrane and Body tissue. The associated genes with 11-cis-retinal are lumirhodopsin, long-wavelength opsin, FASTK Gene, Homologous Gene and Orthologous Gene. The related lipids are cholesterol-hemisuccinate. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of 11-cis-retinal, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 11-cis-retinal?

11-cis-retinal is suspected in Retinal Degeneration, Retinal Diseases, Disintegration, Diabetes, Little's Disease, Pigmentary retinal dystrophy and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with 11-cis-retinal

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 11-cis-retinal?

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What functions are associated with 11-cis-retinal?


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What lipids are associated with 11-cis-retinal?

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What genes are associated with 11-cis-retinal?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 11-cis-retinal?

Knock-out

Knock-out are used in the study 'Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice.' (Sahu B et al., 2015).

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NCBI Entrez Crosslinks

All references with 11-cis-retinal

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Authors Title Published Journal PubMed Link
Song D et al. Retinal Pre-Conditioning by CD59a Knockout Protects against Light-Induced Photoreceptor Degeneration. 2016 PLoS ONE pmid:27893831
Sahu B and Maeda A Retinol Dehydrogenases Regulate Vitamin A Metabolism for Visual Function. 2016 Nutrients pmid:27879662
Kedishvili NY Retinoic Acid Synthesis and Degradation. 2016 Subcell. Biochem. pmid:27830503
Napoli JL Functions of Intracellular Retinoid Binding-Proteins. 2016 Subcell. Biochem. pmid:27830500
Hasemi T et al. Characterization of a Cyanobacterial Chloride-pumping Rhodopsin and Its Conversion into a Proton Pump. 2016 J. Biol. Chem. pmid:26578511
Parfitt DA and Cheetham ME Targeting the Proteostasis Network in Rhodopsin Retinitis Pigmentosa. 2016 Adv. Exp. Med. Biol. pmid:26427449
Zhang Y et al. Retinal-conjugated pH-sensitive micelles induce tumor senescence for boosting breast cancer chemotherapy. 2016 Biomaterials pmid:26774567
Gonzalez-Fernandez F et al. Interphotoreceptor retinoid-binding protein protects retinoids from photodegradation. 2015 Mar-Apr Photochem. Photobiol. pmid:25565073
Li Y et al. Mouse model of human RPE65 P25L hypomorph resembles wild type under normal light rearing but is fully resistant to acute light damage. 2015 Hum. Mol. Genet. pmid:25972377
Zhang M et al. High-fat diet enhanced retinal dehydrogenase activity, but suppressed retinol dehydrogenase activity in liver of rats. 2015 J. Pharmacol. Sci. pmid:25953270