Spisulosine

Spisulosine is a lipid of Sphingolipids (SP) class. Spisulosine is associated with abnormalities such as Infection, Renal impairment and Lesion of brain. The involved functions are known as Gene Expression, Cell Cycle, Drug Kinetics, Signal Transduction and Cell Cycle Arrest. Spisulosine often locates in Body tissue, Microfilaments, Skin, Stress Fibers and Tissue specimen.

Cross Reference

Introduction

To understand associated biological information of Spisulosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Spisulosine?

Spisulosine is suspected in Infection, Renal impairment, Lesion of brain and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Spisulosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Spisulosine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Spisulosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Spisulosine?

There are no associated biomedical information in the current reference collection.

What genes are associated with Spisulosine?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Spisulosine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Spisulosine

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Authors Title Published Journal PubMed Link
Bertea M et al. Deoxysphingoid bases as plasma markers in diabetes mellitus. 2010 Lipids Health Dis pmid:20712864
Baird RD et al. Phase I safety, pharmacokinetic, and pharmacogenomic trial of ES-285, a novel marine cytotoxic agent, administered to adult patients with advanced solid tumors. 2009 Mol. Cancer Ther. pmid:19509256
Sánchez AM et al. Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation. 2008 Eur. J. Pharmacol. pmid:18343365
Pruett ST et al. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. 2008 J. Lipid Res. pmid:18499644
Salcedo M et al. The marine sphingolipid-derived compound ES 285 triggers an atypical cell death pathway. 2007 Apoptosis pmid:17191124
Den Brok MW et al. Compatibility and stability of the novel anticancer agent ES-285 x HCl formulated with 2-hydroxypropyl-beta-cyclodextrin in infusion devices. 2006 Pharmazie pmid:16454201
Faircloth G and Cuevas C Kahalalide F and ES285: potent anticancer agents from marine molluscs. 2006 Prog. Mol. Subcell. Biol. pmid:17153351
Den Brok MW et al. Pharmaceutical development of a parenteral lyophilised formulation of the investigational anticancer agent ES-285.HCl. 2005 Jul-Aug PDA J Pharm Sci Technol pmid:16218203
Stokvis E et al. A more sensitive MS detector does not obviously lead to a more sensitive assay: experiences with ES-285. 2004 Biomed. Chromatogr. pmid:15273982
Yun JM et al. Efficient synthesis of enantiomerically pure 2-acylaziridines: Facile syntheses of N-Boc-safingol, N-Boc-D-erythro-sphinganine, and N-Boc-spisulosine from a common intermediate. 2003 J. Org. Chem. pmid:14510541