N-Palmitoylsphingosine is a lipid of Sphingolipids (SP) class. The involved functions are known as ceramide biosynthetic process, Apoptosis, Regulation, Signal Transduction and Caspase-Dependent Apoptosis. N-palmitoylsphingosine often locates in Mitochondria, Membrane, Extracellular and Endoplasmic Reticulum. The associated genes with N-Palmitoylsphingosine are BCL2 gene, cytochrome c'', BCL2L1 gene, LASS6 gene and LASS5 gene. The related lipids are dihydroceramide, Fatty Acids, Sphingolipids, Palmitates and inositolphosphorylceramide.
To understand associated biological information of N-Palmitoylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with N-Palmitoylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dindo D et al. | Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. | 2006 | Mol. Cancer Ther. | pmid:16818511 |
| Taniguchi Y et al. | Rapid phase change of lipid microdomains in giant vesicles induced by conversion of sphingomyelin to ceramide. | 2006 | Biochim. Biophys. Acta | pmid:16580624 |
| Perez GI et al. | A central role for ceramide in the age-related acceleration of apoptosis in the female germline. | 2005 | FASEB J. | pmid:15728664 |
| Mogami K et al. | Sphingomyelinase causes endothelium-dependent vasorelaxation through endothelial nitric oxide production without cytosolic Ca(2+) elevation. | 2005 | FEBS Lett. | pmid:15642349 |
| Sot J et al. | Molecular associations and surface-active properties of short- and long-N-acyl chain ceramides. | 2005 | Biochim. Biophys. Acta | pmid:15904658 |
| Osawa Y et al. | Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. | 2005 | J. Biol. Chem. | pmid:15946935 |
| Hinz B et al. | R(+)-methanandamide-induced cyclooxygenase-2 expression in H4 human neuroglioma cells: possible involvement of membrane lipid rafts. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474472 |
| Abdel Shakor AB et al. | Cell surface ceramide generation precedes and controls FcgammaRII clustering and phosphorylation in rafts. | 2004 | J. Biol. Chem. | pmid:15194692 |
| Tserng KY and Griffin RL | Ceramide metabolite, not intact ceramide molecule, may be responsible for cellular toxicity. | 2004 | Biochem. J. | pmid:14998372 |
| Bock J et al. | Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12767914 |