Glucosyl sphingosine is a lipid of Sphingolipids (SP) class. Glucosyl sphingosine is associated with abnormalities such as Sphingolipidoses, Globoid cell leukodystrophy, Sandhoff Disease, Tay-Sachs Disease and Fabry Disease. The involved functions are known as Apoptosis, Acetylation, Infiltration, kinase activity and energy pathways. Glucosyl sphingosine often locates in Lysosomal and Protoplasm. The associated genes with Glucosyl sphingosine are MAPT gene, GALC gene, HEXA gene, PICK1 gene and ELF3 gene. The related lipids are lysoganglioside G(M2), Ganglioside GA2, Lysophosphatidylcholines and globotriaosyl lysosphingolipid.
To understand associated biological information of Glucosyl sphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Glucosyl sphingosine is suspected in Globoid cell leukodystrophy, Sphingolipidoses, Sandhoff Disease, Tay-Sachs Disease, Fabry Disease and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Glucosyl sphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Multiple Myeloma | D009101 | 13 associated lipids |
| Leukodystrophy, Globoid Cell | D007965 | 6 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mogi C et al. | Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation. | 2005 | J. Pharmacol. Sci. | pmid:16210776 |
| Deguchi H et al. | Sphingolipids as bioactive regulators of thrombin generation. | 2004 | J. Biol. Chem. | pmid:14722105 |
| Okamoto R et al. | Sphingosylphosphorylcholine is upregulated in the stratum corneum of patients with atopic dermatitis. | 2003 | J. Lipid Res. | pmid:12518027 |
| Lloyd-Evans E et al. | Lyso-glycosphingolipids mobilize calcium from brain microsomes via multiple mechanisms. | 2003 | Biochem. J. | pmid:12917012 |
| Tayebi N et al. | Gaucher disease with parkinsonian manifestations: does glucocerebrosidase deficiency contribute to a vulnerability to parkinsonism? | 2003 | Mol. Genet. Metab. | pmid:12809640 |
| Ishibashi M et al. | Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis. | 2003 | Lab. Invest. | pmid:12649340 |
| Park JK et al. | Myoclonic epilepsy in Gaucher disease: genotype-phenotype insights from a rare patient subgroup. | 2003 | Pediatr. Res. | pmid:12595585 |
| Bodennec J et al. | Simultaneous quantification of lyso-neutral glycosphingolipids and neutral glycosphingolipids by N-acetylation with [3H]acetic anhydride. | 2003 | J. Lipid Res. | pmid:12730305 |
| Schueler UH et al. | Toxicity of glucosylsphingosine (glucopsychosine) to cultured neuronal cells: a model system for assessing neuronal damage in Gaucher disease type 2 and 3. | 2003 | Neurobiol. Dis. | pmid:14678774 |
| Lloyd-Evans E et al. | Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms. | 2003 | J. Biol. Chem. | pmid:12709427 |