PSYCHOSINE is a lipid of Sphingolipids (SP) class. Psychosine is associated with abnormalities such as Globoid cell leukodystrophy, Demyelinating Diseases, Multiple Sclerosis, nervous system disorder and Lysosomal Storage Diseases. The involved functions are known as Ionization, Pathogenesis, Demyelination, 5-(carboxyamino)imidazole ribonucleotide mutase activity and Increased Sensitivy. Psychosine often locates in Body tissue, CNS - Brain (MMHCC), Autosome, Peripheral Nervous System and Nerve Tissue. The associated genes with PSYCHOSINE are GALC gene, NTRK1 gene, JUN gene, ALPP gene and Polylysine. The related lipids are Fatty Acids, fatty aldehyde, lysophosphatidic acid, Stearic acid and stearoyl chloride. The related experimental models are Mouse Model and Streptozotocin Diabetes.
To understand associated biological information of PSYCHOSINE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PSYCHOSINE is suspected in Globoid cell leukodystrophy, Enzyme Deficiency, Demyelinating Diseases, Multiple Sclerosis, nervous system disorder, Lysosomal Storage Diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with PSYCHOSINE
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Leukodystrophy, Metachromatic | D007966 | 4 associated lipids |
| Leukodystrophy, Globoid Cell | D007965 | 6 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
| Optic Atrophy | D009896 | 2 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with PSYCHOSINE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture.' (White AB et al., 2009).
Streptozotocin Diabetes are used in the study 'Direct quantitation of psychosine from alkaline-treated lipid extracts with a semi-synthetic internal standard.' (Jiang X et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Aflaki E et al. | Macrophage models of Gaucher disease for evaluating disease pathogenesis and candidate drugs. | 2014 | Sci Transl Med | pmid:24920659 |
| Voccoli V et al. | Role of extracellular calcium and mitochondrial oxygen species in psychosine-induced oligodendrocyte cell death. | 2014 | Cell Death Dis | pmid:25412308 |
| Claycomb KI et al. | Aberrant production of tenascin-C in globoid cell leukodystrophy alters psychosine-induced microglial functions. | 2014 | J. Neuropathol. Exp. Neurol. | pmid:25192051 |
| Fuss IJ et al. | IL-13Rα2-bearing, type II NKT cells reactive to sulfatide self-antigen populate the mucosa of ulcerative colitis. | 2014 | Gut | pmid:24515806 |
| Gaspar P et al. | Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis. | 2014 | J. Lipid Res. | pmid:24212238 |
| Angka L et al. | Glucopsychosine increases cytosolic calcium to induce calpain-mediated apoptosis of acute myeloid leukemia cells. | 2014 | Cancer Lett. | pmid:24631520 |
| Farfel-Becker T et al. | Neuronal accumulation of glucosylceramide in a mouse model of neuronopathic Gaucher disease leads to neurodegeneration. | 2014 | Hum. Mol. Genet. | pmid:24064337 |
| Miranda CO et al. | Primary bone marrow mesenchymal stromal cells rescue the axonal phenotype of Twitcher mice. | 2014 | Cell Transplant | pmid:23809254 |
| Ribbens JJ et al. | Characterization and application of a disease-cell model for a neurodegenerative lysosomal disease. | 2014 | Mol. Genet. Metab. | pmid:24094551 |
| Welford RW et al. | Plasma lysosphingomyelin demonstrates great potential as a diagnostic biomarker for Niemann-Pick disease type C in a retrospective study. | 2014 | PLoS ONE | pmid:25479233 |