7alpha-Hydroxycholesterol

7alpha-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7alpha-hydroxycholesterol is associated with abnormalities such as Atherosclerosis, Morphologically altered structure, Carotid Atherosclerosis, Myocardial Infarction and Cerebrovascular accident. The involved functions are known as Apoptosis, Cell Growth, Necrosis, Chromosome Condensation and Tissue Adhesions. 7alpha-hydroxycholesterol often locates in Arterial system, Endothelium, Cell Nucleus, Membrane and yolk. The associated genes with 7alpha-Hydroxycholesterol are acetyl-aspartyl-glutamyl-valyl-aspartal, BCL2 gene, OGFR gene, Genome and GAPDH gene. The related lipids are Hydroxycholesterols, 7-ketocholesterol, Ketocholesterols, 20-hydroxycholesterol and 25-hydroxycholesterol.

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Introduction

To understand associated biological information of 7alpha-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 7alpha-Hydroxycholesterol?

7alpha-Hydroxycholesterol is suspected in Kozlowski Celermajer Tink syndrome, Atherosclerosis, Carotid Atherosclerosis, Xanthomatosis, Cerebrotendinous, Keratoconjunctivitis Sicca, Fatty Streak, Arterial and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 7alpha-Hydroxycholesterol

MeSH term MeSH ID Detail
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Carotid Stenosis D016893 15 associated lipids
Plaque, Amyloid D058225 19 associated lipids
Alzheimer Disease D000544 76 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with 7alpha-Hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 7alpha-Hydroxycholesterol?

Related references are published most in these journals:

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What functions are associated with 7alpha-Hydroxycholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 7alpha-Hydroxycholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 7alpha-Hydroxycholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 7alpha-Hydroxycholesterol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 7alpha-Hydroxycholesterol

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Authors Title Published Journal PubMed Link
Kupferberg A et al. Metabolism of 7 beta-hydroxycholesterol in astrocyte primary cultures and derived spontaneously transformed cell lines: correlation between the esterification on C-3 -OH by naturally occurring fatty acids and cytotoxicity. 1990 Biochim. Biophys. Acta pmid:2397239
Carpenter KL et al. Lipids and oxidised lipids in human atherosclerotic lesions at different stages of development. 1995 Biochim. Biophys. Acta pmid:7766691
Tamasawa N et al. The effect of dietary 7-ketocholesterol, inhibitor of sterol synthesis, on hepatic microsomal cholesterol 7 alpha-hydroxylase activity in rat. 1994 Biochim. Biophys. Acta pmid:8068724
Rooney MW et al. Oxygenated cholesterols synergistically immobilize acyl chains and enhance protein helical structure in human erythrocyte membranes. 1985 Biochim. Biophys. Acta pmid:4052416
Bascoul J et al. Serum level of 7 alpha-hydroxycholesterol in hypercholesterolemic patients treated with cholestyramine. 1990 Biochim. Biophys. Acta pmid:2364100
Hammoud Y et al. Oxysterols modulate calcium signalling in the A7r5 aortic smooth muscle cell-line. 2013 Biochimie pmid:22960205
Mitić T et al. 11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol. 2013 Biochimie pmid:22940536
Ogura Y et al. Effect of diabetes and of 7 alpha-hydroxycholesterol infusion on the profile of bile acids secreted by the isolated rat livers. 1986 Biol. Chem. Hoppe-Seyler pmid:3539141
Kang KA et al. Cytotoxic effect of 7beta-hydroxycholesterol on human NCI-H460 lung cancer cells. 2005 Biol. Pharm. Bull. pmid:16079477
Naito Y et al. Inhibitory effects of red wine extracts on endothelial-dependent adhesive interactions with monocytes induced by oxysterols. 2004 Biol. Res. pmid:15455652