7alpha-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7alpha-hydroxycholesterol is associated with abnormalities such as Atherosclerosis, Morphologically altered structure, Carotid Atherosclerosis, Myocardial Infarction and Cerebrovascular accident. The involved functions are known as Apoptosis, Cell Growth, Necrosis, Chromosome Condensation and Tissue Adhesions. 7alpha-hydroxycholesterol often locates in Arterial system, Endothelium, Cell Nucleus, Membrane and yolk. The associated genes with 7alpha-Hydroxycholesterol are acetyl-aspartyl-glutamyl-valyl-aspartal, BCL2 gene, OGFR gene, Genome and GAPDH gene. The related lipids are Hydroxycholesterols, 7-ketocholesterol, Ketocholesterols, 20-hydroxycholesterol and 25-hydroxycholesterol.
To understand associated biological information of 7alpha-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7alpha-Hydroxycholesterol is suspected in Kozlowski Celermajer Tink syndrome, Atherosclerosis, Carotid Atherosclerosis, Xanthomatosis, Cerebrotendinous, Keratoconjunctivitis Sicca, Fatty Streak, Arterial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7alpha-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nashev LG et al. | Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids. | 2007 | PLoS ONE | pmid:17593962 |
| Larsson H et al. | In vivo interconversion of 7beta-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress. | 2007 | Free Radic. Biol. Med. | pmid:17664133 |
| Fuhrman B et al. | Ox-LDL induces monocyte-to-macrophage differentiation in vivo: Possible role for the macrophage colony stimulating factor receptor (M-CSF-R). | 2008 | Atherosclerosis | pmid:17675037 |
| Sun J et al. | Chemical constituents of the red alga Laurencia tristicha. | J Asian Nat Prod Res | pmid:17994390 | |
| Lordan S et al. | Death-signaling pathways in human myeloid cells by oxLDL and its cytotoxic components 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide. | 2007 | J. Biochem. Mol. Toxicol. | pmid:17994574 |
| Lordan S et al. | Effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells. | 2008 | Br. J. Nutr. | pmid:18186953 |
| Lee CY et al. | Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample. | 2008 | Free Radic. Biol. Med. | pmid:18226605 |
| Lemaire-Ewing S et al. | 7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependent. | 2009 | Cell Biol. Toxicol. | pmid:18317936 |
| Rodriguez-Agudo D et al. | Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation. | 2008 | J. Lipid Res. | pmid:18403318 |
| Li W et al. | Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis. | 2009 | Atherosclerosis | pmid:18495127 |
| Crosignani A et al. | Plasma oxysterols in normal and cholestatic children as indicators of the two pathways of bile acid synthesis. | 2008 | Clin. Chim. Acta | pmid:18538136 |
| Alkazemi D et al. | Oxysterol as a marker of atherogenic dyslipidemia in adolescence. | 2008 | J. Clin. Endocrinol. Metab. | pmid:18713821 |
| Malvitte L et al. | Activation of a caspase-3-independent mode of cell death associated with lysosomal destabilization in cultured human retinal pigment epithelial cells (ARPE-19) exposed to 7beta-hydroxycholesterol. | 2008 | Curr. Eye Res. | pmid:18798080 |
| Honda A et al. | Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. | 2009 | J. Lipid Res. | pmid:18815436 |
| Pettersen KS et al. | Toxicity of oxygenated cholesterol derivatives toward cultured human umbilical vein endothelial cells. | 1991 Mar-Apr | Arterioscler. Thromb. | pmid:1900193 |
| Azadmard-Damirchi S and Dutta PC | A single step solid-phase extraction method for complete separation of sterol oxidation products in food lipids. | 2009 | J Chromatogr A | pmid:19056087 |
| Zapolska-Downar D et al. | Anthocyanin-rich Aronox extract from Aronia melanocarpa E protects against 7beta-hydroxycholesterol-induced apoptosis of endothelial cells. | 2008 | Ann. Nutr. Metab. | pmid:19142035 |
| Heiduschka G et al. | 7beta-hydroxycholesterol induces apoptosis and regulates cyclooxygenase 2 in head and neck squamous cell carcinoma. | 2009 | Arch. Otolaryngol. Head Neck Surg. | pmid:19289704 |
| Tang Z et al. | Elucidation of functions of human cytochrome P450 enzymes: identification of endogenous substrates in tissue extracts using metabolomic and isotopic labeling approaches. | 2009 | Anal. Chem. | pmid:19301915 |
| Mazalli MR and Bragagnolo N | Increase of cholesterol oxidation and decrease of PUFA as a result of thermal processing and storage in eggs enriched with n-3 fatty acids. | 2009 | J. Agric. Food Chem. | pmid:19438228 |
| Iuliano L et al. | Association of cholesterol oxidation and abnormalities in fatty acid metabolism in cystic fibrosis. | 2009 | Am. J. Clin. Nutr. | pmid:19587087 |
| Mitomo H et al. | Oxysterol-induced rearrangement of the liquid-ordered phase: a possible link to Alzheimer's disease? | 2009 | J. Am. Chem. Soc. | pmid:19658396 |
| Li W et al. | 7beta-hydroxycholesterol induces natural killer cell death via oxidative lysosomal destabilization. | 2009 | Free Radic. Res. | pmid:19707922 |
| Xu G et al. | Oxidation of cholesterol and beta-sitosterol and prevention by natural antioxidants. | 2009 | J. Agric. Food Chem. | pmid:19754120 |
| Lordan S et al. | The role of calcium in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide. | 2009 Sep-Oct | J. Biochem. Mol. Toxicol. | pmid:19827036 |
| Trevisi L et al. | Antiapoptotic and proliferative effects of low concentrations of 7β-hydroxycholesterol in human endothelial cells via ERK activation. | 2010 | J. Vasc. Res. | pmid:19893321 |
| Lütjohann D et al. | 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man. | 2009 | Int J Clin Pharmacol Ther | pmid:19954708 |
| Wang Y et al. | Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands. | 2010 | J. Biol. Chem. | pmid:19965867 |
| Pignoli G et al. | Effects of different rearing and feeding systems on lipid oxidation and antioxidant capacity of freeze-dried egg yolks. | 2009 | J. Agric. Food Chem. | pmid:20000852 |
| Wong WT et al. | Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. | 2011 | Nutr Metab Cardiovasc Dis | pmid:20005687 |
| Kupferberg A et al. | Differential sensitivity of astrocyte primary cultures and derived spontaneous transformed cell lines to 7 beta-hydroxycholesterol: effect on plasma membrane lipid composition and fluidity, and on cell surface protein expression. | 1991 | Mol. Cell. Biochem. | pmid:2011116 |
| Behr P et al. | Effect of 7 beta-hydroxycholesterol on astrocyte primary cultures and derived spontaneously transformed cell lines. Cytotoxicity and cholesterogenesis. | 1991 | FEBS Lett. | pmid:2013313 |
| Axelson M et al. | Ethanol has an acute effect on bile acid biosynthesis in man. | 1991 | FEBS Lett. | pmid:2015886 |
| Racine R et al. | Cholesterol 7alpha-hydroxylase (CYP7A1) activity is modified after chronic ingestion of depleted uranium in the rat. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20362056 |
| Jenner AM et al. | The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. | 2010 | Neuroscience | pmid:20416362 |
| Laskar A et al. | Prevention of 7β-hydroxycholesterol-induced cell death by mangafodipir is mediated through lysosomal and mitochondrial pathways. | 2010 | Eur. J. Pharmacol. | pmid:20452343 |
| Laskar A et al. | Dimethyl sulfoxide prevents 7β-hydroxycholesterol-induced apoptosis by preserving lysosomes and mitochondria. | 2010 | J. Cardiovasc. Pharmacol. | pmid:20571430 |
| Tang Z and Guengerich FP | Dansylation of unactivated alcohols for improved mass spectral sensitivity and application to analysis of cytochrome P450 oxidation products in tissue extracts. | 2010 | Anal. Chem. | pmid:20795636 |
| Wang Y et al. | Isolation and identification of two steroid compounds from Oviductus Ranae. | 2010 | Nat. Prod. Res. | pmid:20835952 |
| Mascia C et al. | Proinflammatory effect of cholesterol and its oxidation products on CaCo-2 human enterocyte-like cells: effective protection by epigallocatechin-3-gallate. | 2010 | Free Radic. Biol. Med. | pmid:20923702 |
| Carpenter KL et al. | Oxidation of cholesteryl linoleate by human monocyte-macrophages in vitro. | 1990 | Atherosclerosis | pmid:2122906 |
| Gamba P et al. | Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. | 2011 | Aging Cell | pmid:21272192 |
| Seet RC et al. | Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? | 2011 | Free Radic. Biol. Med. | pmid:21420490 |
| Vestergaard MC et al. | The effect of oxycholesterols on thermo-induced membrane dynamics. | 2011 | Biochim. Biophys. Acta | pmid:21600872 |
| Li W et al. | Lipid accumulation and lysosomal pathways contribute to dysfunction and apoptosis of human endothelial cells caused by 7-oxysterols. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21621514 |
| Liu C et al. | Oxysterols direct B-cell migration through EBI2. | 2011 | Nature | pmid:21796211 |
| Carvalho JF et al. | Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR. | 2011 | J. Med. Chem. | pmid:21797280 |
| Iborra RT et al. | Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. | 2011 | Lipids Health Dis | pmid:21957962 |
| Clarion L et al. | 7β-Hydroxycholesterol-induced energy stress leads to sequential opposing signaling responses and to death of C6 glioblastoma cells. | 2012 | Biochem. Pharmacol. | pmid:21983033 |
| Arciello M et al. | Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients. | 2012 | Dig Liver Dis | pmid:22154950 |
| Kwekkeboom J et al. | Bile acids exert negative feedback control on bile acid synthesis in cultured pig hepatocytes by suppression of cholesterol 7 alpha-hydroxylase activity. | 1990 | Hepatology | pmid:2227820 |
| Catarino S et al. | Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells. | 2012 | Acta Ophthalmol | pmid:22313893 |
| Lundåsen T et al. | Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice. | 2012 | PLoS ONE | pmid:22662222 |
| Novikov DK et al. | [Study of HDL2-dependent synthesis of bile acids in culture of rabbit hepatocytes: effects of oxidized cholesterol derivatives]. | 1990 | Biull Eksp Biol Med | pmid:2268710 |
| Mitić T et al. | 11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol. | 2013 | Biochimie | pmid:22940536 |
| Hammoud Y et al. | Oxysterols modulate calcium signalling in the A7r5 aortic smooth muscle cell-line. | 2013 | Biochimie | pmid:22960205 |
| Li W et al. | Cell death induced by 7-oxysterols via lysosomal and mitochondrial pathways is p53-dependent. | 2012 | Free Radic. Biol. Med. | pmid:22985798 |
| Miah S et al. | Expression of Egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53. | 2013 | Exp. Toxicol. Pathol. | pmid:22999639 |
| Chung ML et al. | Profiling of oxidized lipid products of marine fish under acute oxidative stress. | 2013 | Food Chem. Toxicol. | pmid:23220612 |
| Loke SY et al. | Comprehensive gene expression analyses of the rat prefrontal cortex after oxysterol treatment. | 2013 | J. Neurochem. | pmid:23294445 |
| Seet RC et al. | Biomarkers of oxidative damage are elevated among individuals with high cardiovascular risk: refining subject selection strategies for antioxidant trials. | 2013 | Free Radic. Res. | pmid:23343456 |
| Blaabjerg M and Marjanovic D | [Cerebrotendinous xanthomatosis is a rare disorder, which requires a specific treatment]. | 2013 | Ugeskr. Laeg. | pmid:23369332 |
| Mitić T et al. | 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo. | 2013 | Biochem. Pharmacol. | pmid:23415904 |
| Ragot K et al. | Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes. | 2013 | Biochem. Pharmacol. | pmid:23473804 |
| de Weille J et al. | Similar pyruvate kinase modifications in glioblastoma cells by 7β-hydroxycholesterol and glutamine withdrawal. | 2013 | Biochem. Pharmacol. | pmid:23537700 |
| Bascoul J et al. | Serum level of 7 alpha-hydroxycholesterol in hypercholesterolemic patients treated with cholestyramine. | 1990 | Biochim. Biophys. Acta | pmid:2364100 |
| Ji YH et al. | Monophosphoric acid diesters of 7 beta-hydroxycholesterol and of pyrimidine nucleosides as potential antitumor agents: synthesis and preliminary evaluation of antitumor activity. | 1990 | J. Med. Chem. | pmid:2374152 |
| Wang SF et al. | 7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells. | 2013 | Biochem. Pharmacol. | pmid:23792120 |
| Helmschrodt C et al. | Fast LC-MS/MS analysis of free oxysterols derived from reactive oxygen species in human plasma and carotid plaque. | 2013 | Clin. Chim. Acta | pmid:23827692 |
| Noshiro M and Okuda K | Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase. | 1990 | FEBS Lett. | pmid:2384150 |
| Son Y et al. | Oxysterols induce transition of monocytic cells to phenotypically mature dendritic cell-like cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23876312 |
| Hirayama S et al. | Ezetimibe decreases serum oxidized cholesterol without impairing bile acid synthesis in Japanese hypercholesterolemic patients. | 2013 | Atherosclerosis | pmid:23958251 |
| Kupferberg A et al. | Metabolism of 7 beta-hydroxycholesterol in astrocyte primary cultures and derived spontaneously transformed cell lines: correlation between the esterification on C-3 -OH by naturally occurring fatty acids and cytotoxicity. | 1990 | Biochim. Biophys. Acta | pmid:2397239 |
| Laskar A et al. | Fodipir and its dephosphorylated derivative dipyridoxyl ethyldiamine are involved in mangafodipir-mediated cytoprotection against 7β-hydroxycholesterol-induced cell death. | 2013 | Pharmacology | pmid:24080534 |
| Nury T et al. | Improved synthesis and in vitro evaluation of the cytotoxic profile of oxysterols oxidized at C4 (4α- and 4β-hydroxycholesterol) and C7 (7-ketocholesterol, 7α- and 7β-hydroxycholesterol) on cells of the central nervous system. | 2013 | Eur J Med Chem | pmid:24211631 |
| Kim SM et al. | 27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24370436 |
| Helmschrodt C et al. | Preanalytical standardization for reactive oxygen species derived oxysterol analysis in human plasma by liquid chromatography-tandem mass spectrometry. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24370823 |
| Saito Y and Noguchi N | 7-Hydroxycholestrol as a possible biomarker of cellular lipid peroxidation: difference between cellular and plasma lipid peroxidation. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24380859 |
| Khatib S and Vaya J | Oxysterols and symptomatic versus asymptomatic human atherosclerotic plaque. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24393847 |
| Ikegami T et al. | Increased serum oxysterol concentrations in patients with chronic hepatitis C virus infection. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24525121 |
| Testa G et al. | Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols. | 2014 | PLoS ONE | pmid:24802026 |
| Wang Y et al. | Determination of neuroprotective oxysterols in Calculus bovis, human gallstones, and traditional Chinese medicine preparations by liquid chromatography with mass spectrometry. | 2015 | J Sep Sci | pmid:25545614 |
| Javitt NB and Budai K | Cholesterol and bile acid synthesis in Hep G2 cells. Metabolic effects of 26- and 7 alpha-hydroxycholesterol. | 1989 | Biochem. J. | pmid:2556116 |
| Nury T et al. | Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). | 2015 | Steroids | pmid:25683890 |
| Weingärtner O et al. | Vascular effects of oxysterols and oxyphytosterols in apoE -/- mice. | 2015 | Atherosclerosis | pmid:25765595 |
| Son HH et al. | Hair sterol signatures coupled to multivariate data analysis reveal an increased 7β-hydroxycholesterol production in cognitive impairment. | 2016 | J. Steroid Biochem. Mol. Biol. | pmid:26385606 |
| Kim SM et al. | 7α-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C-C motif) ligand 2. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26474699 |
| Frank DJ et al. | Cytochrome P450 125A4, the Third Cholesterol C-26 Hydroxylase from Mycobacterium smegmatis. | 2015 | Biochemistry | pmid:26522442 |
| Rasmiena AA et al. | High density lipoprotein efficiently accepts surface but not internal oxidised lipids from oxidised low density lipoprotein. | 2016 | Biochim. Biophys. Acta | pmid:26569052 |
| Pataj Z et al. | Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. | 2016 | J Chromatogr A | pmid:26607314 |
| Park SH et al. | Dietary compound α-asarone alleviates ER stress-mediated apoptosis in 7β-hydroxycholesterol-challenged macrophages. | 2016 | Mol Nutr Food Res | pmid:26893256 |
| Stellaard F et al. | The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27060336 |
| Keune WJ et al. | Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. | 2016 | Nat Commun | pmid:27075612 |
| Musman J et al. | Regular treadmill exercise inhibits mitochondrial accumulation of cholesterol and oxysterols during myocardial ischemia-reperfusion in wild-type and ob/ob mice. | 2016 | Free Radic. Biol. Med. | pmid:27989751 |
| Kupferberg A et al. | Effect of 7 beta-hydroxycholesterol on astrocyte primary cultures and derived spontaneously transformed cell lines: cytotoxicity and metabolism. | 1989 | Biochim. Biophys. Acta | pmid:2804084 |
| Park SH et al. | α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy. | 2017 | Oncotarget | pmid:28088783 |
| Cho HR et al. | 7α-Hydroxycholesterol induces monocyte/macrophage cell expression of interleukin-8 via C5a receptor. | 2017 | PLoS ONE | pmid:28323848 |
| Deiana M et al. | Derangement of intestinal epithelial cell monolayer by dietary cholesterol oxidation products. | 2017 | Free Radic. Biol. Med. | pmid:29102636 |
| Cho HR et al. | 7-Oxygenated cholesterol molecules differentially affect the expression of zonula occludens-1 in vascular smooth muscle cells and monocyte/macrophage cells. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29428726 |
| Richert L et al. | Inhibition of IL-2 secretion and IL-2 receptor appearance of activated lymphocytes pretreated with hydroxylated sterols. | 1986 | Immunol. Lett. | pmid:3096880 |