7alpha-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7alpha-hydroxycholesterol is associated with abnormalities such as Atherosclerosis, Morphologically altered structure, Carotid Atherosclerosis, Myocardial Infarction and Cerebrovascular accident. The involved functions are known as Apoptosis, Cell Growth, Necrosis, Chromosome Condensation and Tissue Adhesions. 7alpha-hydroxycholesterol often locates in Arterial system, Endothelium, Cell Nucleus, Membrane and yolk. The associated genes with 7alpha-Hydroxycholesterol are acetyl-aspartyl-glutamyl-valyl-aspartal, BCL2 gene, OGFR gene, Genome and GAPDH gene. The related lipids are Hydroxycholesterols, 7-ketocholesterol, Ketocholesterols, 20-hydroxycholesterol and 25-hydroxycholesterol.
To understand associated biological information of 7alpha-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7alpha-Hydroxycholesterol is suspected in Kozlowski Celermajer Tink syndrome, Atherosclerosis, Carotid Atherosclerosis, Xanthomatosis, Cerebrotendinous, Keratoconjunctivitis Sicca, Fatty Streak, Arterial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7alpha-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Son HH et al. | Hair sterol signatures coupled to multivariate data analysis reveal an increased 7β-hydroxycholesterol production in cognitive impairment. | 2016 | J. Steroid Biochem. Mol. Biol. | pmid:26385606 |
| Kuroki S et al. | Effect of biliary drainage on serum 7 alpha-hydroxycholesterol level in patients with obstructive jaundice. | 1994 | J. Surg. Res. | pmid:8072282 |
| Trevisi L et al. | Antiapoptotic and proliferative effects of low concentrations of 7β-hydroxycholesterol in human endothelial cells via ERK activation. | 2010 | J. Vasc. Res. | pmid:19893321 |
| Lim HK et al. | Oxysterols induce apoptosis and accumulation of cell cycle at G(2)/M phase in the human monocytic THP-1 cell line. | 2003 | Life Sci. | pmid:12527036 |
| Kuroki S et al. | Effects of cholestyramine on hepatic cholesterol 7alpha-hydroxylase and serum 7alpha-hydroxycholesterol in the hamster. | 1999 | Lipids | pmid:10529092 |
| Sanghvi A et al. | Effect of detergents on in vitro 7 alpha-hydroxycholesterol formation by rat liver microsomes. | 1982 | Lipids | pmid:7144453 |
| Vatassery GT et al. | Analysis of hydroxy and keto cholesterols in oxidized brain synaptosomes. | 1997 | Lipids | pmid:9075199 |
| Yoshida Y et al. | Levels of lipid peroxidation in human plasma and erythrocytes: comparison between fatty acids and cholesterol. | 2007 | Lipids | pmid:17476548 |
| Ndong-Akoume MY et al. | Simultaneous evaluation of HMG-CoA reductase and cholesterol 7alpha-hydroxylase activities by electrospray tandem MS. | 2002 | Lipids | pmid:12558061 |
| Iborra RT et al. | Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. | 2011 | Lipids Health Dis | pmid:21957962 |