7alpha-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7alpha-hydroxycholesterol is associated with abnormalities such as Atherosclerosis, Morphologically altered structure, Carotid Atherosclerosis, Myocardial Infarction and Cerebrovascular accident. The involved functions are known as Apoptosis, Cell Growth, Necrosis, Chromosome Condensation and Tissue Adhesions. 7alpha-hydroxycholesterol often locates in Arterial system, Endothelium, Cell Nucleus, Membrane and yolk. The associated genes with 7alpha-Hydroxycholesterol are acetyl-aspartyl-glutamyl-valyl-aspartal, BCL2 gene, OGFR gene, Genome and GAPDH gene. The related lipids are Hydroxycholesterols, 7-ketocholesterol, Ketocholesterols, 20-hydroxycholesterol and 25-hydroxycholesterol.
To understand associated biological information of 7alpha-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7alpha-Hydroxycholesterol is suspected in Kozlowski Celermajer Tink syndrome, Atherosclerosis, Carotid Atherosclerosis, Xanthomatosis, Cerebrotendinous, Keratoconjunctivitis Sicca, Fatty Streak, Arterial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 7alpha-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Kishinaka M et al. | Metabolism of intravenously administered 7 alpha-hydroxycholesterol-3 beta-stearate in the hamster. | 1992 | Biochim. Biophys. Acta | pmid:1450217 |
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| Behr P et al. | Effect of 7 beta-hydroxycholesterol on astrocyte primary cultures and derived spontaneously transformed cell lines. Cytotoxicity and cholesterogenesis. | 1991 | FEBS Lett. | pmid:2013313 |
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| Carpenter KL et al. | Oxidation of cholesteryl linoleate by human monocyte-macrophages in vitro. | 1990 | Atherosclerosis | pmid:2122906 |
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| Bascoul J et al. | Serum level of 7 alpha-hydroxycholesterol in hypercholesterolemic patients treated with cholestyramine. | 1990 | Biochim. Biophys. Acta | pmid:2364100 |
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| Kupferberg A et al. | Effect of 7 beta-hydroxycholesterol on astrocyte primary cultures and derived spontaneously transformed cell lines: cytotoxicity and metabolism. | 1989 | Biochim. Biophys. Acta | pmid:2804084 |
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| Björkhem I et al. | On the possible use of the serum level of 7 alpha-hydroxycholesterol as a marker for increased activity of the cholesterol 7 alpha-hydroxylase in humans. | 1987 | J. Lipid Res. | pmid:3668387 |
| Koopman BJ et al. | Determination of some hydroxycholesterols in human serum samples. | 1987 | J. Chromatogr. | pmid:3597624 |
| Richert L et al. | Inhibition of IL-2 secretion and IL-2 receptor appearance of activated lymphocytes pretreated with hydroxylated sterols. | 1986 | Immunol. Lett. | pmid:3096880 |
| Skrede S et al. | Demonstration of 26-hydroxylation of C27-steroids in human skin fibroblasts, and a deficiency of this activity in cerebrotendinous xanthomatosis. | 1986 | J. Clin. Invest. | pmid:3745434 |
| Hietter H et al. | Comparative effects of 7 beta-hydroxycholesterol towards murine lymphomas, lymphoblasts and lymphocytes: selective cytotoxicity and blastogenesis inhibition. | 1986 | Cancer Biochem. Biophys. | pmid:3815322 |
| Ogura Y et al. | Effect of diabetes and of 7 alpha-hydroxycholesterol infusion on the profile of bile acids secreted by the isolated rat livers. | 1986 | Biol. Chem. Hoppe-Seyler | pmid:3539141 |
| Polokoff MA and Everson GT | Hepatocyte-hepatoma cell hybrids. Characterization and demonstration of bile acid synthesis. | 1986 | J. Biol. Chem. | pmid:3949804 |
| Seltman H et al. | Regulation of bile-acid synthesis. Role of sterol carrier protein 2 in the biosynthesis of 7 alpha-hydroxycholesterol. | 1985 | Biochem. J. | pmid:4052036 |
| Rooney MW et al. | Oxygenated cholesterols synergistically immobilize acyl chains and enhance protein helical structure in human erythrocyte membranes. | 1985 | Biochim. Biophys. Acta | pmid:4052416 |
| Hemmi H et al. | Inhibition of sterol and DNA syntheses in phytohemagglutinin-stimulated human lymphocytes by 7 alpha-hydroxycholesterol. | 1985 | Tohoku J. Exp. Med. | pmid:3992580 |
| Hietter H et al. | Antagonist action of cholesterol towards the toxicity of hydroxysterols on cultured hepatoma cells. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6732777 |
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