7alpha-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7alpha-hydroxycholesterol is associated with abnormalities such as Atherosclerosis, Morphologically altered structure, Carotid Atherosclerosis, Myocardial Infarction and Cerebrovascular accident. The involved functions are known as Apoptosis, Cell Growth, Necrosis, Chromosome Condensation and Tissue Adhesions. 7alpha-hydroxycholesterol often locates in Arterial system, Endothelium, Cell Nucleus, Membrane and yolk. The associated genes with 7alpha-Hydroxycholesterol are acetyl-aspartyl-glutamyl-valyl-aspartal, BCL2 gene, OGFR gene, Genome and GAPDH gene. The related lipids are Hydroxycholesterols, 7-ketocholesterol, Ketocholesterols, 20-hydroxycholesterol and 25-hydroxycholesterol.
To understand associated biological information of 7alpha-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7alpha-Hydroxycholesterol is suspected in Kozlowski Celermajer Tink syndrome, Atherosclerosis, Carotid Atherosclerosis, Xanthomatosis, Cerebrotendinous, Keratoconjunctivitis Sicca, Fatty Streak, Arterial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7alpha-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kuroki S et al. | Serum 7 alpha-hydroxycholesterol as a new parameter of liver function in patients with chronic liver diseases. | 1995 | Hepatology | pmid:7557870 |
| Nakano K et al. | Hepatic cholesterol 7 alpha-hydroxylase activity and serum 7 alpha-hydroxy-cholesterol level during liver regeneration after partial hepatectomy in rats. | 1995 | Eur Surg Res | pmid:8542924 |
| Aupeix K et al. | Oyxsterols induce membrane procoagulant activity in monocytic THP-1 cells. | 1996 | Biochem. J. | pmid:8615754 |
| Sauter G et al. | Formation of cholic acid and chenodeoxycholic acid from 7 alpha-hydroxycholesterol and 27-hydroxycholesterol by primary cultures of human hepatocytes. | 1996 | Biochim. Biophys. Acta | pmid:8608157 |
| Patel RP et al. | Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper. | 1996 | J. Lipid Res. | pmid:8978488 |
| Ito T et al. | Hepatic cholesterol metabolism in patients with cholesterol gallstones: enhanced intracellular transport of cholesterol. | 1996 | Gastroenterology | pmid:8613070 |
| Krut LH et al. | The effect of oxidizing cholesterol on gastrointestinal absorption, plasma clearance, tissue distribution, and processing by endothelial cells. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9108794 |
| Lizard G et al. | Induction of apoptosis and of interleukin-1beta secretion by 7beta-hydroxycholesterol and 7-ketocholesterol: partial inhibition by Bcl-2 overexpression. | 1997 | FEBS Lett. | pmid:9428650 |
| Maeda Y et al. | Sex difference in serum 7 alpha-hydroxycholesterol levels in the rat reflect hepatic activity of 3 beta-hydroxy-delta 5-C27-steroid dehydrogenase and cholesterol 7 alpha-hydroxylase. | 1997 | J. Gastroenterol. | pmid:9250898 |
| Matsui H et al. | Increased oxysterol contents in diabetic rat hearts: their involvement in diabetic cardiomyopathy. | 1997 | Can J Cardiol | pmid:9141969 |