4beta-Hydroxycholesterol

4beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 4beta-hydroxycholesterol is associated with abnormalities such as Kidney Failure, Kidney Failure, Chronic, Respiratory Tract Infections, Immunologic Deficiency Syndromes and Infection. The involved functions are known as Selection, Genetic, Renal function, Anabolism, Inflammation and Cell division phases. 4beta-hydroxycholesterol often locates in Hepatic, Blood, Skin and Microsomes. The associated genes with 4beta-Hydroxycholesterol are CYP3A5 gene, Alleles, TERT gene, CYP3A4 gene and CYP3A7 gene. The related lipids are 4-hydroxycholesterol, Hydroxycholesterols, Promega, Pregnanes and 24-hydroxycholesterol.

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Introduction

To understand associated biological information of 4beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4beta-Hydroxycholesterol?

4beta-Hydroxycholesterol is suspected in Kidney Failure, Chronic, Kidney Failure, Respiratory Tract Infections, Immunologic Deficiency Syndromes, Infection, Epilepsy and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with 4beta-Hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4beta-Hydroxycholesterol?

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What functions are associated with 4beta-Hydroxycholesterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with 4beta-Hydroxycholesterol?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 4beta-Hydroxycholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4beta-Hydroxycholesterol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4beta-Hydroxycholesterol

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Authors Title Published Journal PubMed Link
Higashi T et al. LC/MS/MS of steroids having vicinal diol as electrospray-active boronates. 2013 Chem. Pharm. Bull. pmid:23449202
Suzuki Y et al. Significant increase in plasma 4β-hydroxycholesterol concentration in patients after kidney transplantation. 2013 J. Lipid Res. pmid:23833241
Nury T et al. Biological activities of the LXRα and β agonist, 4β-hydroxycholesterol, and of its isomer, 4α-hydroxycholesterol, on oligodendrocytes: effects on cell growth and viability, oxidative and inflammatory status. 2013 Biochimie pmid:23220593
Björkhem-Bergman L et al. Serum levels of 25-hydroxyvitamin D and the CYP3A biomarker 4β-hydroxycholesterol in a high-dose vitamin D supplementation study. 2013 Drug Metab. Dispos. pmid:23386704
Shin KH et al. Evaluation of endogenous metabolic markers of hepatic CYP3A activity using metabolic profiling and midazolam clearance. 2013 Clin. Pharmacol. Ther. pmid:23784264
van de Merbel NC and de Vries R Aging of biological matrices and its effect on bioanalytical method performance. 2013 Bioanalysis pmid:24066624
DeGorter MK et al. Clinical and pharmacogenetic predictors of circulating atorvastatin and rosuvastatin concentrations in routine clinical care. 2013 Circ Cardiovasc Genet pmid:23876492
Xu Y et al. LC-ESI-MS/MS quantification of 4β-hydroxycholesterol and cholesterol in plasma samples of limited volume. 2013 J Pharm Biomed Anal pmid:23948760
Björkhem-Bergman L et al. Comparison of endogenous 4β-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin. 2013 Drug Metab. Dispos. pmid:23674608
Mårde Arrhén Y et al. A comparison of 4β-hydroxycholesterol : cholesterol and 6β-hydroxycortisol : cortisol as markers of CYP3A4 induction. 2013 Br J Clin Pharmacol pmid:23116409