MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tabas I et al. | Unmodified low density lipoprotein causes cholesteryl ester accumulation in J774 macrophages. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3855559 |
Gil G et al. | Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme. | 1985 | Cell | pmid:3995584 |
Quinn PG et al. | Differences in the control of sterol metabolism between mouse and rat Leydig cells. | 1985 | Endocrinology | pmid:3996314 |
Saucier SE et al. | Identification of regulatory oxysterols, 24(S),25-epoxycholesterol and 25-hydroxycholesterol, in cultured fibroblasts. | 1985 | J. Biol. Chem. | pmid:4055791 |
Stone BG et al. | Regulation of rat biliary cholesterol secretion by agents that alter intrahepatic cholesterol metabolism. Evidence for a distinct biliary precursor pool. | 1985 | J. Clin. Invest. | pmid:4056052 |
Peffley D and Sinensky M | Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis by a non-sterol mevalonate-derived product in Mev-1 cells. Apparent translational control. | 1985 | J. Biol. Chem. | pmid:4019518 |
Holt JA and Schreiber JR | Estrogen regulation of steroidogenesis in rabbit luteal cells. | 1985 | Endocrinology | pmid:4065041 |
Taylor FR and Kandutsch AA | Oxysterol binding protein. | 1985 | Chem. Phys. Lipids | pmid:4064220 |
Anderson DK et al. | Spinal cord injury and protection. | 1985 | Ann Emerg Med | pmid:3927795 |
Peng SK et al. | Influence of cholesterol oxidation derivatives on membrane bound enzymes in cultured aortic smooth muscle cells. | 1985 | Proc. Soc. Exp. Biol. Med. | pmid:2994076 |