MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.
To understand associated biological information of 22-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22-Hydroxycholesterol is suspected in Atherosclerosis, Fatty Streak, Arterial, Senile Plaques, Neurodegenerative Disorders, Coronary heart disease, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 22-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Papadopoulos V and Lecanu L | Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties. | 2012 | J. Neuroendocrinol. | pmid:21623958 |
Kittayaruksakul S et al. | Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:22169006 |
Tranheim Kase E et al. | Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. | 2012 | Lipids | pmid:22426832 |
Valbuena-Diez AC et al. | Oxysterol-induced soluble endoglin release and its involvement in hypertension. | 2012 | Circulation | pmid:23110859 |
Soodvilai S et al. | Liver X receptor agonists decrease ENaC-mediated sodium transport in collecting duct cells. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:23077096 |
Kumar R et al. | Altered levels of LXR-α: crucial implications in the pathogenesis of vitiligo. | 2012 | Exp. Dermatol. | pmid:23163651 |
Nader N et al. | Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism. | 2012 | PLoS ONE | pmid:22457708 |
Tsui KH et al. | Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis. | 2012 | Evid Based Complement Alternat Med | pmid:22666287 |
Cacabelos R et al. | Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics. | 2012 | Int J Alzheimers Dis | pmid:22482072 |
Escobar JC et al. | The human placenta expresses CYP17 and generates androgens de novo. | 2011 | J. Clin. Endocrinol. Metab. | pmid:21307141 |