MeSH term | MeSH ID | Detail |
---|---|---|
Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
Arteriosclerosis | D001161 | 86 associated lipids |
22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.
To understand associated biological information of 22-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22-Hydroxycholesterol is suspected in Atherosclerosis, Fatty Streak, Arterial, Senile Plaques, Neurodegenerative Disorders, Coronary heart disease, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 22-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Wang M et al. | Molecular determinants of LXRalpha agonism. | 2003 | J. Mol. Graph. Model. | pmid:12932788 |
Saito Y et al. | Lysis of platelets and erythrocytes by the incorporation of a unique oxygenated sterol: 22R-hydroxycholesterol. | 1985 | J. Membr. Biol. | pmid:3999118 |
Spencer TA et al. | Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. | 2001 | J. Med. Chem. | pmid:11300870 |
Llaverias G et al. | Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism. | 2004 | J. Lipid Res. | pmid:15314095 |
Hong C et al. | Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. | 2011 | J. Lipid Res. | pmid:21187453 |
Murthy S et al. | LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells. | 2002 | J. Lipid Res. | pmid:12091489 |
Buono C et al. | Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL. | 2007 | J. Lipid Res. | pmid:17693624 |
Kaplan R et al. | Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway. | 2002 | J. Lipid Res. | pmid:12032171 |
Qiu G and Hill JS | Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages. | 2007 | J. Lipid Res. | pmid:17644777 |
Wellington CL et al. | Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol. | 2002 | J. Lipid Res. | pmid:12401893 |