MeSH term | MeSH ID | Detail |
---|---|---|
Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
Arteriosclerosis | D001161 | 86 associated lipids |
22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.
To understand associated biological information of 22-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22-Hydroxycholesterol is suspected in Atherosclerosis, Fatty Streak, Arterial, Senile Plaques, Neurodegenerative Disorders, Coronary heart disease, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 22-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kömüves LG et al. | Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. | 2002 | J. Invest. Dermatol. | pmid:11851872 |
Fowler AJ et al. | Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. | 2003 | J. Invest. Dermatol. | pmid:12542530 |
Fluhr JW et al. | Topical liver x receptor activators accelerate postnatal acidification of stratum corneum and improve function in the neonate. | 2005 | J. Invest. Dermatol. | pmid:16354191 |
Hong I et al. | LXRalpha enhances lipid synthesis in SZ95 sebocytes. | 2008 | J. Invest. Dermatol. | pmid:17960176 |
Thiboutot D et al. | Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1). | 2003 | J. Invest. Dermatol. | pmid:12787114 |
Raccosta L et al. | The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. | 2013 | J. Exp. Med. | pmid:23897983 |
Joo SH et al. | Biosynthesis of a cholesterol-derived brassinosteroid, 28-norcastasterone, in Arabidopsis thaliana. | 2012 | J. Exp. Bot. | pmid:22170941 |
Honjo Y et al. | 1,25-dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptor. | 2006 | J. Endocrinol. | pmid:16522742 |
Lin T et al. | Interleukin-1 inhibits Leydig cell steroidogenesis without affecting steroidogenic acute regulatory protein messenger ribonucleic acid or protein levels. | 1998 | J. Endocrinol. | pmid:9582502 |
Ragoobir J et al. | Stimulation of progesterone production in human granulosa-lutein cells by lipoproteins: evidence for cholesterol-independent actions of high-density lipoproteins. | 2002 | J. Endocrinol. | pmid:11927389 |