MeSH term | MeSH ID | Detail |
---|---|---|
Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
Arteriosclerosis | D001161 | 86 associated lipids |
22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.
To understand associated biological information of 22-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22-Hydroxycholesterol is suspected in Atherosclerosis, Fatty Streak, Arterial, Senile Plaques, Neurodegenerative Disorders, Coronary heart disease, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 22-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Meisel ML et al. | Tylosin inhibits the steroidogenesis in mouse Leydig cells "in vitro". | 1993 | Life Sci. | pmid:8390595 |
Liu MY et al. | The inhibitory effects of lead on steroidogenesis in MA-10 mouse Leydig tumor cells. | 2001 | Life Sci. | pmid:11213355 |
Wang YB et al. | Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). | 2007 | J. Toxicol. Environ. Health Part A | pmid:17479410 |
Hessvik NP et al. | The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. | 2012 | J. Steroid Biochem. Mol. Biol. | pmid:22051079 |
Yasuda T et al. | Suppression of inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 22(R)-hydroxycholesterol requires de novo protein synthesis in activated macrophages. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:16146692 |
Picard-Hagen N et al. | Glucocorticoids enhance the cholesterol side-chain cleavage activity of ovine adrenocortical mitochondria. | 1995 | J. Steroid Biochem. Mol. Biol. | pmid:7577721 |
Pezzi V et al. | Role of calmodulin-dependent protein kinase II in the acute stimulation of aldosterone production. | 1996 | J. Steroid Biochem. Mol. Biol. | pmid:8903426 |
Grudet N et al. | Role of proteoglycans on testosterone synthesis by purified Leydig cells from immature and mature rats. | 1999 | J. Steroid Biochem. Mol. Biol. | pmid:10369413 |
Ninomiya Y et al. | Liver X receptor ligands inhibit the lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 and diminish prostaglandin E2 production in murine peritoneal macrophages. | 2007 | J. Steroid Biochem. Mol. Biol. | pmid:17049841 |
Sourdaine P and Garnier DH | Stage-dependent modulation of Sertoli cell steroid production in dogfish (Scyliorhinus canicula). | 1993 | J. Reprod. Fertil. | pmid:8385221 |