22-Hydroxycholesterol

22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.

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Introduction

To understand associated biological information of 22-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 22-Hydroxycholesterol?

22-Hydroxycholesterol is suspected in Atherosclerosis, Fatty Streak, Arterial, Senile Plaques, Neurodegenerative Disorders, Coronary heart disease, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 22-Hydroxycholesterol

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with 22-Hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 22-Hydroxycholesterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 22-Hydroxycholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 22-Hydroxycholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 22-Hydroxycholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 22-Hydroxycholesterol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 22-Hydroxycholesterol

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Authors Title Published Journal PubMed Link
Yoshikawa T et al. Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. 2001 Mol. Cell. Biol. pmid:11287605
Bollag WB et al. Mechanism of angiotensin II-induced phospholipase D activation in bovine adrenal glomerulosa cells. 2002 Mol. Cell. Endocrinol. pmid:12088862
Sriraman V and Jagannadha Rao A Evaluation of the role of FSH in regulation of Leydig cell function during different stages of its differentiation. 2004 Mol. Cell. Endocrinol. pmid:15353182
Abayasekara DR et al. Mode of action of prostaglandin F2 alpha in human luteinized granulosa cells: role of protein kinase C. 1993 Mol. Cell. Endocrinol. pmid:8143907
Slominski AT et al. In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland. 2014 Mol. Cell. Endocrinol. pmid:24382416
Rommerts FF et al. In vitro effects of ethylene-dimethane sulfonate (EDS) on Leydig cells: inhibition of steroid production and cytotoxic effects are dependent on species and age of rat. 1988 Mol. Cell. Endocrinol. pmid:2834244
Engelhardt H et al. Regulation of steroid production in cultured porcine thecal cells by transforming growth factor-beta. 1992 Mol. Cell. Endocrinol. pmid:1326450
Brannian JD et al. Hydrogen peroxide suppresses low-density lipoprotein (LDL) uptake and LDL-supported steroidogenesis by porcine luteal cells. 1995 Mol. Cell. Endocrinol. pmid:7556884
Olala LO et al. A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models. 2013 Mol. Cell. Endocrinol. pmid:23178798
Yamashita S et al. The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility. 2011 Mol. Endocrinol. pmid:21527500
Ide T et al. Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling. 2003 Mol. Endocrinol. pmid:12730332
Mao D et al. ATF3 expression in the corpus luteum: possible role in luteal regression. 2013 Mol. Endocrinol. pmid:24196350
Goodwin B et al. Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha. 2003 Mol. Endocrinol. pmid:12554795
Hauet T et al. Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria. 2005 Mol. Endocrinol. pmid:15498831
Wiebel FF et al. Ligand-independent coregulator recruitment by the triply activatable OR1/retinoid X receptor-alpha nuclear receptor heterodimer. 1999 Mol. Endocrinol. pmid:10406462
Denis M et al. Expression, regulation, and activity of ABCA1 in human cell lines. 2003 Mol. Genet. Metab. pmid:12706378
Adachi T et al. Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells. 2009 Nov-Dec Mol. Pharm. pmid:19588995
Berrodin TJ et al. Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity. 2010 Mol. Pharmacol. pmid:20837678
Gouédard C et al. Opposite regulation of the human paraoxonase-1 gene PON-1 by fenofibrate and statins. 2003 Mol. Pharmacol. pmid:12644596
Xue J et al. [Endothelial dysfunction induced by high glucose is associated with decreased ATP-binding cassette transporter G1 expression]. 2012 Nan Fang Yi Ke Da Xue Xue Bao pmid:22365996