22-Hydroxycholesterol

22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.

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Introduction

To understand associated biological information of 22-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 22-Hydroxycholesterol?

22-Hydroxycholesterol is suspected in Atherosclerosis, Fatty Streak, Arterial, Senile Plaques, Neurodegenerative Disorders, Coronary heart disease, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 22-Hydroxycholesterol

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with 22-Hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 22-Hydroxycholesterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 22-Hydroxycholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 22-Hydroxycholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 22-Hydroxycholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 22-Hydroxycholesterol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 22-Hydroxycholesterol

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Authors Title Published Journal PubMed Link
pmid:
Potocka A and Zimowski J Metabolism of conjugated sterols in eggplant. Part 1. UDP-glucose : sterol glucosyltransferase. 2008 Acta Biochim. Pol. pmid:18196184
Høgmoen Åstrand OA et al. (2S,3S)-2,6-dimethylheptane-1,3-diol, the oxygenated side chain of 22(S)-hydroxycholestrol, and its synthetic precursor (R)-4-benzyl-3-[(2R,3S)-3-hydroxy-2,6-dimethylheptanoyl]-1,3-oxazolidin-2-one. 2013 Acta Crystallogr C pmid:23744388
Huijmans JG et al. Effects of 22S-hydroxy-cholesterol and other hydroxylated sterols on the ACTH-stimulated steroid production in rat adrenal cells. 1981 Acta Endocrinol. pmid:6263029
Huijmans JG et al. Effects of some hydroxylated sterols on the steroid production in isolated rat adrenal glomerulosa and fasciculata/reticularis cells in the presence of potassium, angiotensin II or ACTH. 1984 Acta Endocrinol. pmid:6322498
Huijmans JG et al. Conversion of 22S-hydroxy-cholesterol and its effects on the metabolism of other sterols in rat adrenal cells and bovine adrenal mitochondria. 1982 Acta Endocrinol. pmid:6289587
Tang CK et al. Oxidized LDL upregulated ATP binding cassette transporter-1 in THP-1 macrophages. 2004 Acta Pharmacol. Sin. pmid:15132822
Carr BR and Mason JI The effects of alpha-human atrial natriuretic polypeptide on steroidogenesis by fetal zone cells of the human fetal adrenal gland. 1988 Am. J. Obstet. Gynecol. pmid:2849878
Meikle AW et al. Nonesterified fatty acids modulate steroidogenesis in mouse Leydig cells. 1989 Am. J. Physiol. pmid:2558577
Grenier E et al. Effect of retinoic acid on cell proliferation and differentiation as well as on lipid synthesis, lipoprotein secretion, and apolipoprotein biogenesis. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17916647
Bortnick AE et al. Identification and characterization of rodent ABCA1 in isolated type II pneumocytes. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12909583
Kittayaruksakul S et al. Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule. 2012 Am. J. Physiol. Renal Physiol. pmid:22169006
Soodvilai S et al. Liver X receptor agonists decrease ENaC-mediated sodium transport in collecting duct cells. 2012 Am. J. Physiol. Renal Physiol. pmid:23077096
Bates SR et al. Expression and biological activity of ABCA1 in alveolar epithelial cells. 2008 Am. J. Respir. Cell Mol. Biol. pmid:17884990
Yoshida K et al. Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats. 2018 Andrologia pmid:28295471
Arikan S and Yigit AA Effects of cholesterol and cAMP on progesterone production in cultured luteal cells isolated from pseudopregnant cat ovaries. 2009 Anim. Reprod. Sci. pmid:19135321
Bosc MJ and Nicolle A Androstenedione and progesterone production in vitro by the inner or the outer theca cells in preovulatory follicles of gonadotropin stimulated calves. 1998 Anim. Reprod. Sci. pmid:9672665
El Roz A et al. LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis. 2012 Anticancer Res. pmid:22753765
Chuu CP and Lin HP Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines. 2010 Anticancer Res. pmid:20944148
Huang BM and Liu MY Inhibitory actions of lead on steroidogenesis in MA-10 mouse Leydig tumor cells. 2004 Jan-Feb Arch. Androl. pmid:14660163
Huuskonen J et al. Role of p160 coactivator complex in the activation of liver X receptor. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:14764426
Dubuc G et al. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15178557
Suzuki S et al. Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:14726413
Reddy ST et al. ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells. 2002 Arterioscler. Thromb. Vasc. Biol. pmid:12426219
Ouimet M et al. Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux. 2008 Arterioscler. Thromb. Vasc. Biol. pmid:18369155
Yan D et al. Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17478758
Figueiroa MS et al. Green tea polyphenols inhibit testosterone production in rat Leydig cells. 2009 Asian J. Androl. pmid:19330017
Morello F et al. LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. 2009 Atherosclerosis pmid:19426978
Malerød L et al. Oxysterol-activated LXRalpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes. 2002 Biochem. Biophys. Res. Commun. pmid:12470667
Ohama T et al. Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands. 2002 Biochem. Biophys. Res. Commun. pmid:12176027
Trompier D et al. Regulation of the adrenoleukodystrophy-related gene (ABCD2): focus on oxysterols and LXR antagonists. 2014 Biochem. Biophys. Res. Commun. pmid:24480443
Wang JM et al. 22(R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARγ-LXRα-ABCA1 pathway in cholesterosis of the gallbladder. 2014 Biochem. Biophys. Res. Commun. pmid:24704452
Nishida Y et al. Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency. 2002 Biochem. Biophys. Res. Commun. pmid:11785958
Huang CJ et al. Synergistic activation of RLD-1 by agents triggering PKA and PKC dependent signalling. 1998 Biochem. Biophys. Res. Commun. pmid:9500983
Stein O et al. Macrophage cholesterol efflux to free apoprotein A-I in C3H and C57BL/6 mice. 2002 Biochem. Biophys. Res. Commun. pmid:11820773
Lorkowski S et al. Genomic sequence and structure of the human ABCG1 (ABC8) gene. 2001 Biochem. Biophys. Res. Commun. pmid:11162488
Tu AY and Albers JJ Functional analysis of the transcriptional activity of the mouse phospholipid transfer protein gene. 2001 Biochem. Biophys. Res. Commun. pmid:11573953
Sullivan MH and Cooke BA Stimulation of cholesterol side-chain cleavage by a luteinizing-hormone-releasing hormone (luliberin) agonist (ICI 118630) in rat Leydig cells. 1983 Biochem. J. pmid:6230077
Antonio V et al. Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells. 2003 Biochem. J. pmid:12882648
Schaffer S et al. Stereo specific platelet inhibition by the natural LXR agonist 22(R)-OH-cholesterol and its fluorescence labelling with preserved bioactivity and chiral handling in macrophages. 2013 Biochem. Pharmacol. pmid:23665353
Abayasekara RE and Flint AP A novel phospholipase C inhibitor U73122, inhibits phospholipase C-independent processes in rat luteal cells. 1993 Biochem. Soc. Trans. pmid:8131934
Davydov R et al. Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies. 2015 Biochemistry pmid:26603348
Crow JA et al. Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. 2010 Biochim. Biophys. Acta pmid:19761868
Kase ET et al. 22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes. 2006 Biochim. Biophys. Acta pmid:17055780
Mele PG et al. Site of action of proteinases in the activation of steroidogenesis in rat adrenal gland. 1996 Biochim. Biophys. Acta pmid:8599603
Gondcaille C et al. LXR antagonists induce ABCD2 expression. 2014 Biochim. Biophys. Acta pmid:24239766
Bates SR et al. Prevention of the hyperlipidemic serum or LDL-induced cellular cholesterol ester accumulation by 22-hydroxycholesterol and its analogue. 1983 Biochim. Biophys. Acta pmid:6615863
Kim H et al. 22(R)-hydroxycholesterol induces HuR-dependent MAP kinase phosphatase-1 expression via mGluR5-mediated Ca(2+)/PKCα signaling. 2016 Biochim. Biophys. Acta pmid:27206966
Rzepczynska IJ et al. Role of isoprenylation in simvastatin-induced inhibition of ovarian theca-interstitial growth in the rat. 2009 Biol. Reprod. pmid:19571257
Mauduit C et al. Interleukin-1 alpha as a potent inhibitor of gonadotropin action in porcine Leydig cells: site(s) of action. 1992 Biol. Reprod. pmid:1327201
Sun XR and Risbridger GP Site of macrophage inhibition of luteinizing hormone-stimulated testosterone production by purified leydig cells. 1994 Biol. Reprod. pmid:8142552
Huang BM et al. Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium. 2004 Biol. Reprod. pmid:14711788
Ortega I et al. Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells. 2012 Biol. Reprod. pmid:21918126
Ogilvie KM et al. The inhibitory effect of intracerebroventricularly injected interleukin 1beta on testosterone secretion in the rat: role of steroidogenic acute regulatory protein. 1999 Biol. Reprod. pmid:9916024
Stocco CO and Deis RP Luteinizing hormone inhibits conversion of pregnenolone to progesterone in luteal cells from rats on day 19 of pregnancy. 1999 Biol. Reprod. pmid:10026123
Chen JF et al. Effects of fenvalerate on steroidogenesis in cultured rat granulosa cells. 2005 Biomed. Environ. Sci. pmid:16001830
Singh SB et al. Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. 2005 Bioorg. Med. Chem. Lett. pmid:15911262
Sato H et al. Oxysterol regulation of estrogen receptor alpha-mediated gene expression in a transcriptional activation assay system using HeLa cells. 2004 Biosci. Biotechnol. Biochem. pmid:15322366
Hassan HH et al. Cellular cholesterol homeostasis in vascular endothelial cells. 2006 Can J Cardiol pmid:16498511
Perez A et al. Expression of nuclear receptors and apo E secretion during the differentiation of monocytic THP-1 cells into macrophages. 2003 Cell Biol. Toxicol. pmid:12776927
Huwait EA et al. A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression. 2011 Cell. Signal. pmid:21070853
Wang Y et al. Low concentrations mono-butyl phthalate stimulates steroidogenesis by facilitating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). 2006 Chem. Biol. Interact. pmid:16999944
García MM et al. Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc. 2012 Chem. Biol. Interact. pmid:22940207
Chiu CH et al. Characterization of a stable steroidogenic caprine luteal cell line transformed by a temperature-sensitive simian virus 40. 2008 Chin J Physiol pmid:19280881
Ou J et al. Effects of D-4F on vasodilation and vessel wall thickness in hypercholesterolemic LDL receptor-null and LDL receptor/apolipoprotein A-I double-knockout mice on Western diet. 2005 Circ. Res. pmid:16224061
Valbuena-Diez AC et al. Oxysterol-induced soluble endoglin release and its involvement in hypertension. 2012 Circulation pmid:23110859
O'Connell BJ et al. Cellular physiology of cholesterol efflux in vascular endothelial cells. 2004 Circulation pmid:15492319
Cruz-Garcia L et al. Regulation of LXR by fatty acids, insulin, growth hormone and tumor necrosis factor-α in rainbow trout myocytes. 2011 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:21635958
Calayir E et al. LXR-agonists regulate ApoM expression differentially in liver and intestine. 2008 Curr Pharm Biotechnol pmid:19075690
Cardellini M et al. TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1. 2009 Diabetes pmid:19581416
Kase ET et al. Liver X receptor antagonist reduces lipid formation and increases glucose metabolism in myotubes from lean, obese and type 2 diabetic individuals. 2007 Diabetologia pmid:17661008
Nazarov PA et al. Formation and functioning of fused cholesterol side-chain cleavage enzymes. 2003 DNA Cell Biol. pmid:12823901
Shenoy SD et al. CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor. 2004 Drug Metab. Dispos. pmid:14709622
Cornejo Maciel F et al. Phosphotyrosine protein phosphatases activation by ACTH in rat adrenal gland. 1998 Aug-Nov Endocr. Res. pmid:9888510
Yu CC and Li PH In vivo inhibition of steroidogenic acute regulatory protein expression by dexamethasone parallels induction of the negative transcription factor DAX-1. 2006 Endocrine pmid:17526944
Mauduit C et al. Leukemia inhibitory factor antagonizes gonadotropin induced-testosterone synthesis in cultured porcine leydig cells: sites of action. 2001 Endocrinology pmid:11356700
Musicki B et al. Inhibition of protein synthesis and hormone-sensitive steroidogenesis in response to hydrogen peroxide in rat luteal cells. 1994 Endocrinology pmid:7507829
Cymeryng CB et al. Effects of L-arginine in rat adrenal cells: involvement of nitric oxide synthase. 1999 Endocrinology pmid:10385387
Allen JA et al. Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis. 2006 Endocrinology pmid:16690799
Lee JH et al. Androgen deprivation by activating the liver X receptor. 2008 Endocrinology pmid:18450964
Doris PA et al. Ouabain production by cultured adrenal cells. 1996 Endocrinology pmid:8593799
Kolmakova A et al. Deficiency of scavenger receptor class B type I negatively affects progesterone secretion in human granulosa cells. 2010 Endocrinology pmid:20844007
Mauduit C et al. Tumor necrosis factor alpha inhibits gonadotropin action in cultured porcine Leydig cells: site(s) of action. 1991 Endocrinology pmid:1659519
Stocco DM et al. The effects of hydrogen peroxide on steroidogenesis in mouse Leydig tumor cells. 1993 Endocrinology pmid:8243310
Guo H et al. Interleukin-2 is a potent inhibitor of Leydig cell steroidogenesis. 1990 Endocrinology pmid:2167211
Freeman DA et al. Finasteride blocks progesterone synthesis in MA-10 Leydig tumor cells. 1993 Endocrinology pmid:8404636
Menke JG et al. A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). 2002 Endocrinology pmid:12072387
Gocze PM and Freeman DA A cholesteryl ester hydrolase inhibitor blocks cholesterol translocation into the mitochondria of MA-10 Leydig tumor cells. 1992 Endocrinology pmid:1332853
Lin T et al. Interferon-gamma inhibits the steroidogenic acute regulatory protein messenger ribonucleic acid expression and protein levels in primary cultures of rat Leydig cells. 1998 Endocrinology pmid:9564825
Huang MC and Miller WL Creation and activity of COS-1 cells stably expressing the F2 fusion of the human cholesterol side-chain cleavage enzyme system. 2001 Endocrinology pmid:11356706
Tsui KH et al. Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis. 2012 Evid Based Complement Alternat Med pmid:22666287
Nguyen DH and Taub DD Membrane incorporation of 22-hydroxycholesterol inhibits chemokine receptor activity. 2003 Exp. Cell Res. pmid:12706121
Demerjian M et al. Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis. 2009 Exp. Dermatol. pmid:19236478
Kumar R et al. Altered levels of LXR-α: crucial implications in the pathogenesis of vitiligo. 2012 Exp. Dermatol. pmid:23163651
Chen W et al. Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone. 2010 Exp. Dermatol. pmid:20337700
Hsu CC et al. Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis. 2003 FEBS Lett. pmid:12753921
Marinero MJ et al. Specific effect of arachidonic acid on 17beta-hydroxysteroid dehydrogenase in rat Leydig cells. 1998 FEBS Lett. pmid:9475159
Jezová M et al. Luteinization factor-stimulated steroidogenesis in porcine granulosa cells. 2001 Gen. Physiol. Biophys. pmid:11519688
Chiang JY et al. Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). 2001 Gene pmid:11179691
Grochowski D and Szamatowicz M [The role of gonadotropins, cyclic AMP, 22-R-hydroxycholesterol and cofactors in regulating endocrine functions of the Leydig cells in rats. II. Effects of LH, hCG, dbcAMP, 22-R-OH-cholesterol and cofactors on the synthesis of pregnenolone and testosterone in the interstitial gland of rats]. 1989 Ginekol. Pol. pmid:2561359