22-Hydroxycholesterol

22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.

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Introduction

To understand associated biological information of 22-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 22-Hydroxycholesterol?

22-Hydroxycholesterol is suspected in Atherosclerosis, Fatty Streak, Arterial, Senile Plaques, Neurodegenerative Disorders, Coronary heart disease, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 22-Hydroxycholesterol

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with 22-Hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 22-Hydroxycholesterol?

Related references are published most in these journals:

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What functions are associated with 22-Hydroxycholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 22-Hydroxycholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 22-Hydroxycholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 22-Hydroxycholesterol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 22-Hydroxycholesterol

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Authors Title Published Journal PubMed Link
pmid:
Stocco CO and Deis RP Luteinizing hormone inhibits conversion of pregnenolone to progesterone in luteal cells from rats on day 19 of pregnancy. 1999 Biol. Reprod. pmid:10026123
Grudet N et al. Role of proteoglycans on testosterone synthesis by purified Leydig cells from immature and mature rats. 1999 J. Steroid Biochem. Mol. Biol. pmid:10369413
Cymeryng CB et al. Effects of L-arginine in rat adrenal cells: involvement of nitric oxide synthase. 1999 Endocrinology pmid:10385387
Wiebel FF et al. Ligand-independent coregulator recruitment by the triply activatable OR1/retinoid X receptor-alpha nuclear receptor heterodimer. 1999 Mol. Endocrinol. pmid:10406462
Hanley K et al. Fetal epidermal differentiation and barrier development In vivo is accelerated by nuclear hormone receptor activators. 1999 J. Invest. Dermatol. pmid:10571735
Hanley K et al. Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. 2000 J. Invest. Dermatol. pmid:10692116
Murono EP et al. Octylphenol inhibits testosterone biosynthesis by cultured precursor and immature Leydig cells from rat testes. 2000 May-Jun Reprod. Toxicol. pmid:10838129
Costet P et al. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. 2000 J. Biol. Chem. pmid:10858438
Laffitte BA et al. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11149950
Lorkowski S et al. Genomic sequence and structure of the human ABCG1 (ABC8) gene. 2001 Biochem. Biophys. Res. Commun. pmid:11162488
DeBose-Boyd RA et al. Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11171976
Chiang JY et al. Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). 2001 Gene pmid:11179691
Liu MY et al. The inhibitory effects of lead on steroidogenesis in MA-10 mouse Leydig tumor cells. 2001 Life Sci. pmid:11213355
Wu CS et al. Melatonin inhibits the expression of steroidogenic acute regulatory protein and steroidogenesis in MA-10 cells. 2001 Mar-Apr J. Androl. pmid:11229798
Yoshikawa T et al. Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. 2001 Mol. Cell. Biol. pmid:11287605
Spencer TA et al. Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. 2001 J. Med. Chem. pmid:11300870
Mauduit C et al. Leukemia inhibitory factor antagonizes gonadotropin induced-testosterone synthesis in cultured porcine leydig cells: sites of action. 2001 Endocrinology pmid:11356700
Huang MC and Miller WL Creation and activity of COS-1 cells stably expressing the F2 fusion of the human cholesterol side-chain cleavage enzyme system. 2001 Endocrinology pmid:11356706
Fu X et al. 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. 2001 J. Biol. Chem. pmid:11504730
Jezová M et al. Luteinization factor-stimulated steroidogenesis in porcine granulosa cells. 2001 Gen. Physiol. Biophys. pmid:11519688
Tu AY and Albers JJ Functional analysis of the transcriptional activity of the mouse phospholipid transfer protein gene. 2001 Biochem. Biophys. Res. Commun. pmid:11573953
Gan X et al. Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate. 2001 J. Biol. Chem. pmid:11641412
Landis MS et al. Oxysterol activators of liver X receptor and 9-cis-retinoic acid promote sequential steps in the synthesis and secretion of tumor necrosis factor-alpha from human monocytes. 2002 J. Biol. Chem. pmid:11741944
Nishida Y et al. Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency. 2002 Biochem. Biophys. Res. Commun. pmid:11785958
Sparrow CP et al. A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux. 2002 J. Biol. Chem. pmid:11790770
Stein O et al. Macrophage cholesterol efflux to free apoprotein A-I in C3H and C57BL/6 mice. 2002 Biochem. Biophys. Res. Commun. pmid:11820773
Goldman JM and Murr AS Alterations in ovarian follicular progesterone secretion by elevated exposures to the drinking water disinfection by-product dibromoacetic acid: examination of the potential site(s) of impact along the steroidogenic pathway. 2002 Toxicology pmid:11836015
Kömüves LG et al. Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. 2002 J. Invest. Dermatol. pmid:11851872
Ragoobir J et al. Stimulation of progesterone production in human granulosa-lutein cells by lipoproteins: evidence for cholesterol-independent actions of high-density lipoproteins. 2002 J. Endocrinol. pmid:11927389
Kaplan R et al. Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway. 2002 J. Lipid Res. pmid:12032171
Menke JG et al. A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). 2002 Endocrinology pmid:12072387
Bollag WB et al. Mechanism of angiotensin II-induced phospholipase D activation in bovine adrenal glomerulosa cells. 2002 Mol. Cell. Endocrinol. pmid:12088862
Murthy S et al. LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells. 2002 J. Lipid Res. pmid:12091489
Ohama T et al. Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands. 2002 Biochem. Biophys. Res. Commun. pmid:12176027
Fukumoto H et al. Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels. 2002 J. Biol. Chem. pmid:12384498
Wellington CL et al. Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol. 2002 J. Lipid Res. pmid:12401893
Reddy ST et al. ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells. 2002 Arterioscler. Thromb. Vasc. Biol. pmid:12426219
Yao ZX et al. 22R-Hydroxycholesterol protects neuronal cells from beta-amyloid-induced cytotoxicity by binding to beta-amyloid peptide. 2002 J. Neurochem. pmid:12437582
Malerød L et al. Oxysterol-activated LXRalpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes. 2002 Biochem. Biophys. Res. Commun. pmid:12470667
Jabara S et al. Stromal cells of the human postmenopausal ovary display a distinctive biochemical and molecular phenotype. 2003 J. Clin. Endocrinol. Metab. pmid:12519894
Fowler AJ et al. Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. 2003 J. Invest. Dermatol. pmid:12542530
Koldamova RP et al. 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. 2003 J. Biol. Chem. pmid:12547833
Goodwin B et al. Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha. 2003 Mol. Endocrinol. pmid:12554795
Kocarek TA et al. Use of dominant negative nuclear receptors to study xenobiotic-inducible gene expression in primary cultured hepatocytes. 2002 May-Jun J Pharmacol Toxicol Methods pmid:12628309
Gouédard C et al. Opposite regulation of the human paraoxonase-1 gene PON-1 by fenofibrate and statins. 2003 Mol. Pharmacol. pmid:12644596
Cheng J et al. The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory (StAR) protein expression. 2003 Toxicology pmid:12699903
Nguyen DH and Taub DD Membrane incorporation of 22-hydroxycholesterol inhibits chemokine receptor activity. 2003 Exp. Cell Res. pmid:12706121
Denis M et al. Expression, regulation, and activity of ABCA1 in human cell lines. 2003 Mol. Genet. Metab. pmid:12706378
Ide T et al. Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling. 2003 Mol. Endocrinol. pmid:12730332
Hsu CC et al. Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis. 2003 FEBS Lett. pmid:12753921
Perez A et al. Expression of nuclear receptors and apo E secretion during the differentiation of monocytic THP-1 cells into macrophages. 2003 Cell Biol. Toxicol. pmid:12776927
Thiboutot D et al. Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1). 2003 J. Invest. Dermatol. pmid:12787114
Nazarov PA et al. Formation and functioning of fused cholesterol side-chain cleavage enzymes. 2003 DNA Cell Biol. pmid:12823901
Kaneko E et al. Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist. 2003 J. Biol. Chem. pmid:12847102
Xia H and Redman CM Oxysterols suppress constitutive fibrinogen expression. 2003 Thromb. Haemost. pmid:12876624
Antonio V et al. Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells. 2003 Biochem. J. pmid:12882648
Bortnick AE et al. Identification and characterization of rodent ABCA1 in isolated type II pneumocytes. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12909583
Wang M et al. Molecular determinants of LXRalpha agonism. 2003 J. Mol. Graph. Model. pmid:12932788
Engelhardt H et al. Regulation of steroid production in cultured porcine thecal cells by transforming growth factor-beta. 1992 Mol. Cell. Endocrinol. pmid:1326450
Mauduit C et al. Interleukin-1 alpha as a potent inhibitor of gonadotropin action in porcine Leydig cells: site(s) of action. 1992 Biol. Reprod. pmid:1327201
Gocze PM and Freeman DA A cholesteryl ester hydrolase inhibitor blocks cholesterol translocation into the mitochondria of MA-10 Leydig tumor cells. 1992 Endocrinology pmid:1332853
CHAUDHURI AC et al. Biosynthesis of pregnenolone from 22-hydroxycholesterol. 1962 J. Biol. Chem. pmid:13878470
Ishida BY et al. Regulated expression of apolipoprotein E by human retinal pigment epithelial cells. 2004 J. Lipid Res. pmid:14594998
Huang BM and Liu MY Inhibitory actions of lead on steroidogenesis in MA-10 mouse Leydig tumor cells. 2004 Jan-Feb Arch. Androl. pmid:14660163
Denis M et al. Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1). 2004 J. Biol. Chem. pmid:14660648
Haidar B et al. Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter. 2004 J. Biol. Chem. pmid:14701824
Shenoy SD et al. CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor. 2004 Drug Metab. Dispos. pmid:14709622
Huang BM et al. Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium. 2004 Biol. Reprod. pmid:14711788
Lecanu L et al. Identification of naturally occurring spirostenols preventing beta-amyloid-induced neurotoxicity. 2004 Steroids pmid:14715372
Suzuki S et al. Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:14726413
Krimbou L et al. Molecular interactions between apoE and ABCA1: impact on apoE lipidation. 2004 J. Lipid Res. pmid:14754908
Huuskonen J et al. Role of p160 coactivator complex in the activation of liver X receptor. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:14764426
Field FJ et al. LXR/RXR ligand activation enhances basolateral efflux of beta-sitosterol in CaCo-2 cells. 2004 J. Lipid Res. pmid:14993242
Yoon JH et al. Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis. 2004 Hepatology pmid:14999691
Tang CK et al. Oxidized LDL upregulated ATP binding cassette transporter-1 in THP-1 macrophages. 2004 Acta Pharmacol. Sin. pmid:15132822
Dubuc G et al. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15178557
Schmuth M et al. The effect of LXR activators on AP-1 proteins in keratinocytes. 2004 J. Invest. Dermatol. pmid:15191540
Ando H et al. Effects of pravastatin on the expression of ATP-binding cassette transporter A1. 2004 J. Pharmacol. Exp. Ther. pmid:15210833
Tomita M et al. Effect of 22R-hydroxycholesterol on the action of sphingomyelinase from Bacillus cereus toward bovine erythrocytes. 1992 Toxicon pmid:1523674
Llaverias G et al. Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism. 2004 J. Lipid Res. pmid:15314095
Sato H et al. Oxysterol regulation of estrogen receptor alpha-mediated gene expression in a transcriptional activation assay system using HeLa cells. 2004 Biosci. Biotechnol. Biochem. pmid:15322366
Sriraman V and Jagannadha Rao A Evaluation of the role of FSH in regulation of Leydig cell function during different stages of its differentiation. 2004 Mol. Cell. Endocrinol. pmid:15353182
Matyash V et al. Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16. 2004 PLoS Biol. pmid:15383841
O'Connell BJ et al. Cellular physiology of cholesterol efflux in vascular endothelial cells. 2004 Circulation pmid:15492319
Hauet T et al. Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria. 2005 Mol. Endocrinol. pmid:15498831
Poon SL et al. Regulatory mechanism of Toona sinensis on mouse leydig cell steroidogenesis. 2005 Life Sci. pmid:15680312
Agassandian M et al. Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:phosphocholine cytidylyltransferase. 2005 J. Biol. Chem. pmid:15788406
Shouhed D et al. Osteogenic oxysterols inhibit the adverse effects of oxidative stress on osteogenic differentiation of marrow stromal cells. 2005 J. Cell. Biochem. pmid:15880703
Chen J et al. Effects of fenvalerate on progesterone production in cultured rat granulosa cells. 2005 Jul-Aug Reprod. Toxicol. pmid:15907653
Singh SB et al. Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. 2005 Bioorg. Med. Chem. Lett. pmid:15911262
Chen JF et al. Effects of fenvalerate on steroidogenesis in cultured rat granulosa cells. 2005 Biomed. Environ. Sci. pmid:16001830
Norata GD et al. Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells. 2005 Int. J. Mol. Med. pmid:16142410
Yasuda T et al. Suppression of inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 22(R)-hydroxycholesterol requires de novo protein synthesis in activated macrophages. 2005 J. Steroid Biochem. Mol. Biol. pmid:16146692
Ou J et al. Effects of D-4F on vasodilation and vessel wall thickness in hypercholesterolemic LDL receptor-null and LDL receptor/apolipoprotein A-I double-knockout mice on Western diet. 2005 Circ. Res. pmid:16224061
Weedon-Fekjaer MS et al. Liver X receptors mediate inhibition of hCG secretion in a human placental trophoblast cell line. 2005 Placenta pmid:16226121
Fluhr JW et al. Topical liver x receptor activators accelerate postnatal acidification of stratum corneum and improve function in the neonate. 2005 J. Invest. Dermatol. pmid:16354191
Albers M et al. A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors. 2006 J. Biol. Chem. pmid:16354658
Deng R et al. Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor. 2006 J. Pharmacol. Exp. Ther. pmid:16371446
Lee CS et al. Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor. 2006 Neuroreport pmid:16407768