Yoshida K et al. |
Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats. |
2018 |
Andrologia |
pmid:28295471
|
Yi M et al. |
Expression of CYP4V2 in human THP1 macrophages and its transcriptional regulation by peroxisome proliferator-activated receptor gamma. |
2017 |
Toxicol. Appl. Pharmacol. |
pmid:28729181
|
Li J et al. |
Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis. |
2017 |
Reprod. Biol. Endocrinol. |
pmid:28302174
|
Venugopal S et al. |
Plasma Membrane Origin of the Steroidogenic Pool of Cholesterol Used in Hormone-induced Acute Steroid Formation in Leydig Cells. |
2016 |
J. Biol. Chem. |
pmid:27815506
|
Kim H et al. |
22(R)-hydroxycholesterol induces HuR-dependent MAP kinase phosphatase-1 expression via mGluR5-mediated Ca(2+)/PKCα signaling. |
2016 |
Biochim. Biophys. Acta |
pmid:27206966
|
Ceroi A et al. |
The anti-inflammatory effects of platelet-derived microparticles in human plasmacytoid dendritic cells involve liver X receptor activation. |
2016 |
Haematologica |
pmid:26635040
|
Huwait EA et al. |
Protein Kinase C Is Involved in the Induction of ATP-Binding Cassette Transporter A1 Expression by Liver X Receptor/Retinoid X Receptor Agonist in Human Macrophages. |
2015 |
J. Cell. Biochem. |
pmid:25752819
|
Newby EA et al. |
Adrenocorticotropic Hormone and PI3K/Akt Inhibition Reduce eNOS Phosphorylation and Increase Cortisol Biosynthesis in Long-Term Hypoxic Ovine Fetal Adrenal Cortical Cells. |
2015 |
Reprod Sci |
pmid:25656500
|
Na TY et al. |
22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. |
2015 |
J. Pathol. |
pmid:25557254
|
Davydov R et al. |
Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies. |
2015 |
Biochemistry |
pmid:26603348
|
Trompier D et al. |
Regulation of the adrenoleukodystrophy-related gene (ABCD2): focus on oxysterols and LXR antagonists. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:24480443
|
Wang JM et al. |
22(R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARγ-LXRα-ABCA1 pathway in cholesterosis of the gallbladder. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:24704452
|
Gondcaille C et al. |
LXR antagonists induce ABCD2 expression. |
2014 |
Biochim. Biophys. Acta |
pmid:24239766
|
Slominski AT et al. |
In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland. |
2014 |
Mol. Cell. Endocrinol. |
pmid:24382416
|
Soodgupta D et al. |
Modulation of LXR-α and the effector genes by Ascorbic acid and Statins in psoriatic keratinocytes. |
2014 |
Mol. Cell. Biochem. |
pmid:25283515
|
Mao D et al. |
ATF3 expression in the corpus luteum: possible role in luteal regression. |
2013 |
Mol. Endocrinol. |
pmid:24196350
|
Høgmoen Åstrand OA et al. |
(2S,3S)-2,6-dimethylheptane-1,3-diol, the oxygenated side chain of 22(S)-hydroxycholestrol, and its synthetic precursor (R)-4-benzyl-3-[(2R,3S)-3-hydroxy-2,6-dimethylheptanoyl]-1,3-oxazolidin-2-one. |
2013 |
Acta Crystallogr C |
pmid:23744388
|
Raccosta L et al. |
The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. |
2013 |
J. Exp. Med. |
pmid:23897983
|
Schaffer S et al. |
Stereo specific platelet inhibition by the natural LXR agonist 22(R)-OH-cholesterol and its fluorescence labelling with preserved bioactivity and chiral handling in macrophages. |
2013 |
Biochem. Pharmacol. |
pmid:23665353
|
Olala LO et al. |
A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models. |
2013 |
Mol. Cell. Endocrinol. |
pmid:23178798
|
El Roz A et al. |
LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis. |
2012 |
Anticancer Res. |
pmid:22753765
|
Papadopoulos V and Lecanu L |
Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties. |
2012 |
J. Neuroendocrinol. |
pmid:21623958
|
Hessvik NP et al. |
The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. |
2012 |
J. Steroid Biochem. Mol. Biol. |
pmid:22051079
|
Lecanu L et al. |
A steroid isolated from the water mold Achlya heterosexualis induces neurogenesis in vitro and in vivo. |
2012 |
Steroids |
pmid:22138207
|
Li W et al. |
Establishment and evaluation of a stable steroidogenic caprine luteal cell line. |
2012 |
Theriogenology |
pmid:22578611
|
GarcÃa MM et al. |
Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc. |
2012 |
Chem. Biol. Interact. |
pmid:22940207
|
Kittayaruksakul S et al. |
Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule. |
2012 |
Am. J. Physiol. Renal Physiol. |
pmid:22169006
|
Tranheim Kase E et al. |
Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. |
2012 |
Lipids |
pmid:22426832
|
Valbuena-Diez AC et al. |
Oxysterol-induced soluble endoglin release and its involvement in hypertension. |
2012 |
Circulation |
pmid:23110859
|
Soodvilai S et al. |
Liver X receptor agonists decrease ENaC-mediated sodium transport in collecting duct cells. |
2012 |
Am. J. Physiol. Renal Physiol. |
pmid:23077096
|
Kumar R et al. |
Altered levels of LXR-α: crucial implications in the pathogenesis of vitiligo. |
2012 |
Exp. Dermatol. |
pmid:23163651
|
López-Velázquez JA et al. |
Nuclear receptors in nonalcoholic Fatty liver disease. |
2012 |
J Lipids |
pmid:22187655
|
Nader N et al. |
Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism. |
2012 |
PLoS ONE |
pmid:22457708
|
Tsui KH et al. |
Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis. |
2012 |
Evid Based Complement Alternat Med |
pmid:22666287
|
Cacabelos R et al. |
Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics. |
2012 |
Int J Alzheimers Dis |
pmid:22482072
|
Xue J et al. |
[Endothelial dysfunction induced by high glucose is associated with decreased ATP-binding cassette transporter G1 expression]. |
2012 |
Nan Fang Yi Ke Da Xue Xue Bao |
pmid:22365996
|
Lin HP et al. |
Caffeic acid phenethyl ester causes p21 induction, Akt signaling reduction, and growth inhibition in PC-3 human prostate cancer cells. |
2012 |
PLoS ONE |
pmid:22347457
|
Ortega I et al. |
Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells. |
2012 |
Biol. Reprod. |
pmid:21918126
|
Joo SH et al. |
Biosynthesis of a cholesterol-derived brassinosteroid, 28-norcastasterone, in Arabidopsis thaliana. |
2012 |
J. Exp. Bot. |
pmid:22170941
|
Amemiya-Kudo M et al. |
Suppression of the pancreatic duodenal homeodomain transcription factor-1 (Pdx-1) promoter by sterol regulatory element-binding protein-1c (SREBP-1c). |
2011 |
J. Biol. Chem. |
pmid:21652712
|
Yamashita S et al. |
The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility. |
2011 |
Mol. Endocrinol. |
pmid:21527500
|
Cruz-Garcia L et al. |
Regulation of LXR by fatty acids, insulin, growth hormone and tumor necrosis factor-α in rainbow trout myocytes. |
2011 |
Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. |
pmid:21635958
|
Mast N et al. |
Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. |
2011 |
J. Biol. Chem. |
pmid:21159775
|
Iborra RT et al. |
Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. |
2011 |
Lipids Health Dis |
pmid:21957962
|
Escobar JC et al. |
The human placenta expresses CYP17 and generates androgens de novo. |
2011 |
J. Clin. Endocrinol. Metab. |
pmid:21307141
|
Mastrocola R et al. |
Dysregulation of SREBP2 induces BACE1 expression. |
2011 |
Neurobiol. Dis. |
pmid:21726644
|
Hong C et al. |
Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. |
2011 |
J. Lipid Res. |
pmid:21187453
|
Huwait EA et al. |
A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression. |
2011 |
Cell. Signal. |
pmid:21070853
|
Flück CE et al. |
Characterization of novel StAR (steroidogenic acute regulatory protein) mutations causing non-classic lipoid adrenal hyperplasia. |
2011 |
PLoS ONE |
pmid:21647419
|
Carter CJ |
The Fox and the Rabbits-Environmental Variables and Population Genetics (1) Replication Problems in Association Studies and the Untapped Power of GWAS (2) Vitamin A Deficiency, Herpes Simplex Reactivation and Other Causes of Alzheimer's Disease. |
2011 |
ISRN Neurol |
pmid:22389816
|
Jusakul A et al. |
Mechanisms of oxysterol-induced carcinogenesis. |
2011 |
Lipids Health Dis |
pmid:21388551
|
Aye IL et al. |
Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors. |
2011 |
Placenta |
pmid:21208656
|
Girard E et al. |
The dynamin chemical inhibitor dynasore impairs cholesterol trafficking and sterol-sensitive genes transcription in human HeLa cells and macrophages. |
2011 |
PLoS ONE |
pmid:22205993
|
Chuu CP et al. |
Androgens as therapy for androgen receptor-positive castration-resistant prostate cancer. |
2011 |
J. Biomed. Sci. |
pmid:21859492
|
Gupta V |
Mineralocorticoid hypertension. |
2011 |
Indian J Endocrinol Metab |
pmid:22145132
|
Vallim T and Salter AM |
Regulation of hepatic gene expression by saturated fatty acids. |
2010 Apr-Jun |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:20227267
|
Sokalska A et al. |
Statins inhibit growth of human theca-interstitial cells in PCOS and non-PCOS tissues independently of cholesterol availability. |
2010 |
J. Clin. Endocrinol. Metab. |
pmid:20826585
|
Berrodin TJ et al. |
Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity. |
2010 |
Mol. Pharmacol. |
pmid:20837678
|
Chuu CP and Lin HP |
Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines. |
2010 |
Anticancer Res. |
pmid:20944148
|
Matsushita K et al. |
Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha. |
2010 |
J. Biol. Chem. |
pmid:20118482
|
Crow JA et al. |
Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. |
2010 |
Biochim. Biophys. Acta |
pmid:19761868
|
Couto JA et al. |
Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies. |
2010 |
Reprod. Biol. Endocrinol. |
pmid:20144211
|
Chen W et al. |
Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone. |
2010 |
Exp. Dermatol. |
pmid:20337700
|
Kolmakova A et al. |
Deficiency of scavenger receptor class B type I negatively affects progesterone secretion in human granulosa cells. |
2010 |
Endocrinology |
pmid:20844007
|
Arikan Åž et al. |
Effects of cholesterol on progesterone production by goat luteal cell subpopulations at two different stages of the luteal phase. |
2010 |
Reprod. Domest. Anim. |
pmid:20345591
|
Kotani H et al. |
Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor. |
2010 |
J. Nat. Prod. |
pmid:20695472
|
Crisafulli C et al. |
Effects of Liver x receptor agonist treatment on signal transduction pathways in acute lung inflammation. |
2010 |
Respir. Res. |
pmid:20175894
|
Salehipour M et al. |
Polyunsaturated fatty acids and modulation of cholesterol homeostasis in THP-1 macrophage-derived foam cells. |
2010 |
Int J Mol Sci |
pmid:21151462
|
Adachi T et al. |
Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells. |
2009 Nov-Dec |
Mol. Pharm. |
pmid:19588995
|
Demerjian M et al. |
Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis. |
2009 |
Exp. Dermatol. |
pmid:19236478
|
Arikan S and Yigit AA |
Effects of cholesterol and cAMP on progesterone production in cultured luteal cells isolated from pseudopregnant cat ovaries. |
2009 |
Anim. Reprod. Sci. |
pmid:19135321
|
Albergotti LC et al. |
Endocrine activity of extraembryonic membranes extends beyond placental amniotes. |
2009 |
PLoS ONE |
pmid:19424488
|
Hynynen R et al. |
OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. |
2009 |
J. Lipid Res. |
pmid:19224871
|
Li T and Chiang JY |
Regulation of bile acid and cholesterol metabolism by PPARs. |
2009 |
PPAR Res |
pmid:19636418
|
Figueiroa MS et al. |
Green tea polyphenols inhibit testosterone production in rat Leydig cells. |
2009 |
Asian J. Androl. |
pmid:19330017
|
Rzepczynska IJ et al. |
Role of isoprenylation in simvastatin-induced inhibition of ovarian theca-interstitial growth in the rat. |
2009 |
Biol. Reprod. |
pmid:19571257
|
Honda A et al. |
Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. |
2009 |
J. Lipid Res. |
pmid:18815436
|
Cardellini M et al. |
TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1. |
2009 |
Diabetes |
pmid:19581416
|
Minagawa H et al. |
Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture. |
2009 |
J. Neurosci. Res. |
pmid:19326444
|
Morello F et al. |
LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. |
2009 |
Atherosclerosis |
pmid:19426978
|
Patel MB et al. |
Liver x receptor: a novel therapeutic target. |
2008 Mar-Apr |
Indian J Pharm Sci |
pmid:20046702
|
Chiu CH et al. |
Characterization of a stable steroidogenic caprine luteal cell line transformed by a temperature-sensitive simian virus 40. |
2008 |
Chin J Physiol |
pmid:19280881
|
Lee JH et al. |
Androgen deprivation by activating the liver X receptor. |
2008 |
Endocrinology |
pmid:18450964
|
Qu JH et al. |
Fenvalerate inhibits progesterone production through cAMP-dependent signal pathway. |
2008 |
Toxicol. Lett. |
pmid:18053657
|
Zhao SP et al. |
Dual effects of oxidized low-density lipoprotein on LXR-ABCA1-apoA-I pathway in 3T3-L1 cells. |
2008 |
Int. J. Cardiol. |
pmid:17643522
|
Noguchi N |
Role of oxidative stress in adaptive responses in special reference to atherogenesis. |
2008 |
J Clin Biochem Nutr |
pmid:19015746
|
Bowden K and Ridgway ND |
OSBP negatively regulates ABCA1 protein stability. |
2008 |
J. Biol. Chem. |
pmid:18450749
|
Bates SR et al. |
Expression and biological activity of ABCA1 in alveolar epithelial cells. |
2008 |
Am. J. Respir. Cell Mol. Biol. |
pmid:17884990
|
Ouimet M et al. |
Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux. |
2008 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:18369155
|
Hong I et al. |
LXRalpha enhances lipid synthesis in SZ95 sebocytes. |
2008 |
J. Invest. Dermatol. |
pmid:17960176
|
Calayir E et al. |
LXR-agonists regulate ApoM expression differentially in liver and intestine. |
2008 |
Curr Pharm Biotechnol |
pmid:19075690
|
Potocka A and Zimowski J |
Metabolism of conjugated sterols in eggplant. Part 1. UDP-glucose : sterol glucosyltransferase. |
2008 |
Acta Biochim. Pol. |
pmid:18196184
|
Wang YB et al. |
Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). |
2007 |
J. Toxicol. Environ. Health Part A |
pmid:17479410
|
Yao ZX et al. |
22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. |
2007 |
Neuroscience |
pmid:17689017
|
Grenier E et al. |
Effect of retinoic acid on cell proliferation and differentiation as well as on lipid synthesis, lipoprotein secretion, and apolipoprotein biogenesis. |
2007 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:17916647
|
Yu BL et al. |
[Effects of oxidized low-density lipoprotein on cholesterol efflux in 3T3-L1 cells]. |
2007 |
Zhong Nan Da Xue Xue Bao Yi Xue Ban |
pmid:17767055
|
Buono C et al. |
Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL. |
2007 |
J. Lipid Res. |
pmid:17693624
|
Aghaloo TL et al. |
Oxysterols enhance osteoblast differentiation in vitro and bone healing in vivo. |
2007 |
J. Orthop. Res. |
pmid:17568450
|
Yan D et al. |
Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice. |
2007 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:17478758
|
Qiu G and Hill JS |
Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages. |
2007 |
J. Lipid Res. |
pmid:17644777
|