22-Hydroxycholesterol

22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.

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Introduction

To understand associated biological information of 22-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 22-Hydroxycholesterol?

22-Hydroxycholesterol is suspected in Atherosclerosis, Fatty Streak, Arterial, Senile Plaques, Neurodegenerative Disorders, Coronary heart disease, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 22-Hydroxycholesterol

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with 22-Hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 22-Hydroxycholesterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 22-Hydroxycholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 22-Hydroxycholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 22-Hydroxycholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 22-Hydroxycholesterol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 22-Hydroxycholesterol

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Authors Title Published Journal PubMed Link
Yoshida K et al. Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats. 2018 Andrologia pmid:28295471
Yi M et al. Expression of CYP4V2 in human THP1 macrophages and its transcriptional regulation by peroxisome proliferator-activated receptor gamma. 2017 Toxicol. Appl. Pharmacol. pmid:28729181
Li J et al. Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis. 2017 Reprod. Biol. Endocrinol. pmid:28302174
Venugopal S et al. Plasma Membrane Origin of the Steroidogenic Pool of Cholesterol Used in Hormone-induced Acute Steroid Formation in Leydig Cells. 2016 J. Biol. Chem. pmid:27815506
Kim H et al. 22(R)-hydroxycholesterol induces HuR-dependent MAP kinase phosphatase-1 expression via mGluR5-mediated Ca(2+)/PKCα signaling. 2016 Biochim. Biophys. Acta pmid:27206966
Ceroi A et al. The anti-inflammatory effects of platelet-derived microparticles in human plasmacytoid dendritic cells involve liver X receptor activation. 2016 Haematologica pmid:26635040
Huwait EA et al. Protein Kinase C Is Involved in the Induction of ATP-Binding Cassette Transporter A1 Expression by Liver X Receptor/Retinoid X Receptor Agonist in Human Macrophages. 2015 J. Cell. Biochem. pmid:25752819
Newby EA et al. Adrenocorticotropic Hormone and PI3K/Akt Inhibition Reduce eNOS Phosphorylation and Increase Cortisol Biosynthesis in Long-Term Hypoxic Ovine Fetal Adrenal Cortical Cells. 2015 Reprod Sci pmid:25656500
Na TY et al. 22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. 2015 J. Pathol. pmid:25557254
Davydov R et al. Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies. 2015 Biochemistry pmid:26603348
Trompier D et al. Regulation of the adrenoleukodystrophy-related gene (ABCD2): focus on oxysterols and LXR antagonists. 2014 Biochem. Biophys. Res. Commun. pmid:24480443
Wang JM et al. 22(R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARγ-LXRα-ABCA1 pathway in cholesterosis of the gallbladder. 2014 Biochem. Biophys. Res. Commun. pmid:24704452
Gondcaille C et al. LXR antagonists induce ABCD2 expression. 2014 Biochim. Biophys. Acta pmid:24239766
Slominski AT et al. In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland. 2014 Mol. Cell. Endocrinol. pmid:24382416
Soodgupta D et al. Modulation of LXR-α and the effector genes by Ascorbic acid and Statins in psoriatic keratinocytes. 2014 Mol. Cell. Biochem. pmid:25283515
Mao D et al. ATF3 expression in the corpus luteum: possible role in luteal regression. 2013 Mol. Endocrinol. pmid:24196350
Høgmoen Åstrand OA et al. (2S,3S)-2,6-dimethylheptane-1,3-diol, the oxygenated side chain of 22(S)-hydroxycholestrol, and its synthetic precursor (R)-4-benzyl-3-[(2R,3S)-3-hydroxy-2,6-dimethylheptanoyl]-1,3-oxazolidin-2-one. 2013 Acta Crystallogr C pmid:23744388
Raccosta L et al. The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. 2013 J. Exp. Med. pmid:23897983
Schaffer S et al. Stereo specific platelet inhibition by the natural LXR agonist 22(R)-OH-cholesterol and its fluorescence labelling with preserved bioactivity and chiral handling in macrophages. 2013 Biochem. Pharmacol. pmid:23665353
Olala LO et al. A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models. 2013 Mol. Cell. Endocrinol. pmid:23178798
El Roz A et al. LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis. 2012 Anticancer Res. pmid:22753765
Papadopoulos V and Lecanu L Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties. 2012 J. Neuroendocrinol. pmid:21623958
Hessvik NP et al. The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. 2012 J. Steroid Biochem. Mol. Biol. pmid:22051079
Lecanu L et al. A steroid isolated from the water mold Achlya heterosexualis induces neurogenesis in vitro and in vivo. 2012 Steroids pmid:22138207
Li W et al. Establishment and evaluation of a stable steroidogenic caprine luteal cell line. 2012 Theriogenology pmid:22578611
García MM et al. Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc. 2012 Chem. Biol. Interact. pmid:22940207
Kittayaruksakul S et al. Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule. 2012 Am. J. Physiol. Renal Physiol. pmid:22169006
Tranheim Kase E et al. Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. 2012 Lipids pmid:22426832
Valbuena-Diez AC et al. Oxysterol-induced soluble endoglin release and its involvement in hypertension. 2012 Circulation pmid:23110859
Soodvilai S et al. Liver X receptor agonists decrease ENaC-mediated sodium transport in collecting duct cells. 2012 Am. J. Physiol. Renal Physiol. pmid:23077096
Kumar R et al. Altered levels of LXR-α: crucial implications in the pathogenesis of vitiligo. 2012 Exp. Dermatol. pmid:23163651
López-Velázquez JA et al. Nuclear receptors in nonalcoholic Fatty liver disease. 2012 J Lipids pmid:22187655
Nader N et al. Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism. 2012 PLoS ONE pmid:22457708
Tsui KH et al. Molecular Mechanism of Isocupressic Acid Supresses MA-10 Cell Steroidogenesis. 2012 Evid Based Complement Alternat Med pmid:22666287
Cacabelos R et al. Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics. 2012 Int J Alzheimers Dis pmid:22482072
Xue J et al. [Endothelial dysfunction induced by high glucose is associated with decreased ATP-binding cassette transporter G1 expression]. 2012 Nan Fang Yi Ke Da Xue Xue Bao pmid:22365996
Lin HP et al. Caffeic acid phenethyl ester causes p21 induction, Akt signaling reduction, and growth inhibition in PC-3 human prostate cancer cells. 2012 PLoS ONE pmid:22347457
Ortega I et al. Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells. 2012 Biol. Reprod. pmid:21918126
Joo SH et al. Biosynthesis of a cholesterol-derived brassinosteroid, 28-norcastasterone, in Arabidopsis thaliana. 2012 J. Exp. Bot. pmid:22170941
Amemiya-Kudo M et al. Suppression of the pancreatic duodenal homeodomain transcription factor-1 (Pdx-1) promoter by sterol regulatory element-binding protein-1c (SREBP-1c). 2011 J. Biol. Chem. pmid:21652712
Yamashita S et al. The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility. 2011 Mol. Endocrinol. pmid:21527500
Cruz-Garcia L et al. Regulation of LXR by fatty acids, insulin, growth hormone and tumor necrosis factor-α in rainbow trout myocytes. 2011 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:21635958
Mast N et al. Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. 2011 J. Biol. Chem. pmid:21159775
Iborra RT et al. Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. 2011 Lipids Health Dis pmid:21957962
Escobar JC et al. The human placenta expresses CYP17 and generates androgens de novo. 2011 J. Clin. Endocrinol. Metab. pmid:21307141
Mastrocola R et al. Dysregulation of SREBP2 induces BACE1 expression. 2011 Neurobiol. Dis. pmid:21726644
Hong C et al. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. 2011 J. Lipid Res. pmid:21187453
Huwait EA et al. A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression. 2011 Cell. Signal. pmid:21070853
Flück CE et al. Characterization of novel StAR (steroidogenic acute regulatory protein) mutations causing non-classic lipoid adrenal hyperplasia. 2011 PLoS ONE pmid:21647419
Carter CJ The Fox and the Rabbits-Environmental Variables and Population Genetics (1) Replication Problems in Association Studies and the Untapped Power of GWAS (2) Vitamin A Deficiency, Herpes Simplex Reactivation and Other Causes of Alzheimer's Disease. 2011 ISRN Neurol pmid:22389816
Jusakul A et al. Mechanisms of oxysterol-induced carcinogenesis. 2011 Lipids Health Dis pmid:21388551
Aye IL et al. Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors. 2011 Placenta pmid:21208656
Girard E et al. The dynamin chemical inhibitor dynasore impairs cholesterol trafficking and sterol-sensitive genes transcription in human HeLa cells and macrophages. 2011 PLoS ONE pmid:22205993
Chuu CP et al. Androgens as therapy for androgen receptor-positive castration-resistant prostate cancer. 2011 J. Biomed. Sci. pmid:21859492
Gupta V Mineralocorticoid hypertension. 2011 Indian J Endocrinol Metab pmid:22145132
Vallim T and Salter AM Regulation of hepatic gene expression by saturated fatty acids. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20227267
Sokalska A et al. Statins inhibit growth of human theca-interstitial cells in PCOS and non-PCOS tissues independently of cholesterol availability. 2010 J. Clin. Endocrinol. Metab. pmid:20826585
Berrodin TJ et al. Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity. 2010 Mol. Pharmacol. pmid:20837678
Chuu CP and Lin HP Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines. 2010 Anticancer Res. pmid:20944148
Matsushita K et al. Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha. 2010 J. Biol. Chem. pmid:20118482
Crow JA et al. Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. 2010 Biochim. Biophys. Acta pmid:19761868
Couto JA et al. Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies. 2010 Reprod. Biol. Endocrinol. pmid:20144211
Chen W et al. Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone. 2010 Exp. Dermatol. pmid:20337700
Kolmakova A et al. Deficiency of scavenger receptor class B type I negatively affects progesterone secretion in human granulosa cells. 2010 Endocrinology pmid:20844007
Arikan Åž et al. Effects of cholesterol on progesterone production by goat luteal cell subpopulations at two different stages of the luteal phase. 2010 Reprod. Domest. Anim. pmid:20345591
Kotani H et al. Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor. 2010 J. Nat. Prod. pmid:20695472
Crisafulli C et al. Effects of Liver x receptor agonist treatment on signal transduction pathways in acute lung inflammation. 2010 Respir. Res. pmid:20175894
Salehipour M et al. Polyunsaturated fatty acids and modulation of cholesterol homeostasis in THP-1 macrophage-derived foam cells. 2010 Int J Mol Sci pmid:21151462
Adachi T et al. Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells. 2009 Nov-Dec Mol. Pharm. pmid:19588995
Demerjian M et al. Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis. 2009 Exp. Dermatol. pmid:19236478
Arikan S and Yigit AA Effects of cholesterol and cAMP on progesterone production in cultured luteal cells isolated from pseudopregnant cat ovaries. 2009 Anim. Reprod. Sci. pmid:19135321
Albergotti LC et al. Endocrine activity of extraembryonic membranes extends beyond placental amniotes. 2009 PLoS ONE pmid:19424488
Hynynen R et al. OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. 2009 J. Lipid Res. pmid:19224871
Li T and Chiang JY Regulation of bile acid and cholesterol metabolism by PPARs. 2009 PPAR Res pmid:19636418
Figueiroa MS et al. Green tea polyphenols inhibit testosterone production in rat Leydig cells. 2009 Asian J. Androl. pmid:19330017
Rzepczynska IJ et al. Role of isoprenylation in simvastatin-induced inhibition of ovarian theca-interstitial growth in the rat. 2009 Biol. Reprod. pmid:19571257
Honda A et al. Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. 2009 J. Lipid Res. pmid:18815436
Cardellini M et al. TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1. 2009 Diabetes pmid:19581416
Minagawa H et al. Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture. 2009 J. Neurosci. Res. pmid:19326444
Morello F et al. LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. 2009 Atherosclerosis pmid:19426978
Patel MB et al. Liver x receptor: a novel therapeutic target. 2008 Mar-Apr Indian J Pharm Sci pmid:20046702
Chiu CH et al. Characterization of a stable steroidogenic caprine luteal cell line transformed by a temperature-sensitive simian virus 40. 2008 Chin J Physiol pmid:19280881
Lee JH et al. Androgen deprivation by activating the liver X receptor. 2008 Endocrinology pmid:18450964
Qu JH et al. Fenvalerate inhibits progesterone production through cAMP-dependent signal pathway. 2008 Toxicol. Lett. pmid:18053657
Zhao SP et al. Dual effects of oxidized low-density lipoprotein on LXR-ABCA1-apoA-I pathway in 3T3-L1 cells. 2008 Int. J. Cardiol. pmid:17643522
Noguchi N Role of oxidative stress in adaptive responses in special reference to atherogenesis. 2008 J Clin Biochem Nutr pmid:19015746
Bowden K and Ridgway ND OSBP negatively regulates ABCA1 protein stability. 2008 J. Biol. Chem. pmid:18450749
Bates SR et al. Expression and biological activity of ABCA1 in alveolar epithelial cells. 2008 Am. J. Respir. Cell Mol. Biol. pmid:17884990
Ouimet M et al. Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux. 2008 Arterioscler. Thromb. Vasc. Biol. pmid:18369155
Hong I et al. LXRalpha enhances lipid synthesis in SZ95 sebocytes. 2008 J. Invest. Dermatol. pmid:17960176
Calayir E et al. LXR-agonists regulate ApoM expression differentially in liver and intestine. 2008 Curr Pharm Biotechnol pmid:19075690
Potocka A and Zimowski J Metabolism of conjugated sterols in eggplant. Part 1. UDP-glucose : sterol glucosyltransferase. 2008 Acta Biochim. Pol. pmid:18196184
Wang YB et al. Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). 2007 J. Toxicol. Environ. Health Part A pmid:17479410
Yao ZX et al. 22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. 2007 Neuroscience pmid:17689017
Grenier E et al. Effect of retinoic acid on cell proliferation and differentiation as well as on lipid synthesis, lipoprotein secretion, and apolipoprotein biogenesis. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17916647
Yu BL et al. [Effects of oxidized low-density lipoprotein on cholesterol efflux in 3T3-L1 cells]. 2007 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:17767055
Buono C et al. Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL. 2007 J. Lipid Res. pmid:17693624
Aghaloo TL et al. Oxysterols enhance osteoblast differentiation in vitro and bone healing in vivo. 2007 J. Orthop. Res. pmid:17568450
Yan D et al. Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17478758
Qiu G and Hill JS Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages. 2007 J. Lipid Res. pmid:17644777