| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
Total
2
22-Hydroxycholesterol
22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.
Cross Reference
Introduction
To understand associated biological information of 22-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 22-Hydroxycholesterol?
22-Hydroxycholesterol is suspected in Atherosclerosis, Fatty Streak, Arterial, Senile Plaques, Neurodegenerative Disorders, Coronary heart disease, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Arterioscler. Thromb. Vasc. Biol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 22-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 22-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 22-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (3)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Others (8)
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 22-Hydroxycholesterol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 22-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Stocco CO and Deis RP | Luteinizing hormone inhibits conversion of pregnenolone to progesterone in luteal cells from rats on day 19 of pregnancy. | 1999 | Biol. Reprod. | pmid:10026123 |
| Grudet N et al. | Role of proteoglycans on testosterone synthesis by purified Leydig cells from immature and mature rats. | 1999 | J. Steroid Biochem. Mol. Biol. | pmid:10369413 |
| Cymeryng CB et al. | Effects of L-arginine in rat adrenal cells: involvement of nitric oxide synthase. | 1999 | Endocrinology | pmid:10385387 |
| Wiebel FF et al. | Ligand-independent coregulator recruitment by the triply activatable OR1/retinoid X receptor-alpha nuclear receptor heterodimer. | 1999 | Mol. Endocrinol. | pmid:10406462 |
| Hanley K et al. | Fetal epidermal differentiation and barrier development In vivo is accelerated by nuclear hormone receptor activators. | 1999 | J. Invest. Dermatol. | pmid:10571735 |
| Hanley K et al. | Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. | 2000 | J. Invest. Dermatol. | pmid:10692116 |
| Murono EP et al. | Octylphenol inhibits testosterone biosynthesis by cultured precursor and immature Leydig cells from rat testes. | 2000 May-Jun | Reprod. Toxicol. | pmid:10838129 |
| Costet P et al. | Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. | 2000 | J. Biol. Chem. | pmid:10858438 |
| Laffitte BA et al. | LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11149950 |
| Lorkowski S et al. | Genomic sequence and structure of the human ABCG1 (ABC8) gene. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11162488 |
| DeBose-Boyd RA et al. | Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11171976 |
| Chiang JY et al. | Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). | 2001 | Gene | pmid:11179691 |
| Liu MY et al. | The inhibitory effects of lead on steroidogenesis in MA-10 mouse Leydig tumor cells. | 2001 | Life Sci. | pmid:11213355 |
| Wu CS et al. | Melatonin inhibits the expression of steroidogenic acute regulatory protein and steroidogenesis in MA-10 cells. | 2001 Mar-Apr | J. Androl. | pmid:11229798 |
| Yoshikawa T et al. | Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. | 2001 | Mol. Cell. Biol. | pmid:11287605 |
| Spencer TA et al. | Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. | 2001 | J. Med. Chem. | pmid:11300870 |
| Mauduit C et al. | Leukemia inhibitory factor antagonizes gonadotropin induced-testosterone synthesis in cultured porcine leydig cells: sites of action. | 2001 | Endocrinology | pmid:11356700 |
| Huang MC and Miller WL | Creation and activity of COS-1 cells stably expressing the F2 fusion of the human cholesterol side-chain cleavage enzyme system. | 2001 | Endocrinology | pmid:11356706 |
| Fu X et al. | 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. | 2001 | J. Biol. Chem. | pmid:11504730 |
| Jezová M et al. | Luteinization factor-stimulated steroidogenesis in porcine granulosa cells. | 2001 | Gen. Physiol. Biophys. | pmid:11519688 |
| Tu AY and Albers JJ | Functional analysis of the transcriptional activity of the mouse phospholipid transfer protein gene. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11573953 |
| Gan X et al. | Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate. | 2001 | J. Biol. Chem. | pmid:11641412 |
| Landis MS et al. | Oxysterol activators of liver X receptor and 9-cis-retinoic acid promote sequential steps in the synthesis and secretion of tumor necrosis factor-alpha from human monocytes. | 2002 | J. Biol. Chem. | pmid:11741944 |
| Nishida Y et al. | Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11785958 |
| Sparrow CP et al. | A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux. | 2002 | J. Biol. Chem. | pmid:11790770 |
| Stein O et al. | Macrophage cholesterol efflux to free apoprotein A-I in C3H and C57BL/6 mice. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11820773 |
| Goldman JM and Murr AS | Alterations in ovarian follicular progesterone secretion by elevated exposures to the drinking water disinfection by-product dibromoacetic acid: examination of the potential site(s) of impact along the steroidogenic pathway. | 2002 | Toxicology | pmid:11836015 |
| Kömüves LG et al. | Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. | 2002 | J. Invest. Dermatol. | pmid:11851872 |
| Ragoobir J et al. | Stimulation of progesterone production in human granulosa-lutein cells by lipoproteins: evidence for cholesterol-independent actions of high-density lipoproteins. | 2002 | J. Endocrinol. | pmid:11927389 |
| Kaplan R et al. | Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway. | 2002 | J. Lipid Res. | pmid:12032171 |
| Menke JG et al. | A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). | 2002 | Endocrinology | pmid:12072387 |
| Bollag WB et al. | Mechanism of angiotensin II-induced phospholipase D activation in bovine adrenal glomerulosa cells. | 2002 | Mol. Cell. Endocrinol. | pmid:12088862 |
| Murthy S et al. | LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells. | 2002 | J. Lipid Res. | pmid:12091489 |
| Ohama T et al. | Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12176027 |
| Fukumoto H et al. | Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels. | 2002 | J. Biol. Chem. | pmid:12384498 |
| Wellington CL et al. | Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol. | 2002 | J. Lipid Res. | pmid:12401893 |
| Reddy ST et al. | ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:12426219 |
| Yao ZX et al. | 22R-Hydroxycholesterol protects neuronal cells from beta-amyloid-induced cytotoxicity by binding to beta-amyloid peptide. | 2002 | J. Neurochem. | pmid:12437582 |
| Malerød L et al. | Oxysterol-activated LXRalpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12470667 |
| Jabara S et al. | Stromal cells of the human postmenopausal ovary display a distinctive biochemical and molecular phenotype. | 2003 | J. Clin. Endocrinol. Metab. | pmid:12519894 |
| Fowler AJ et al. | Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. | 2003 | J. Invest. Dermatol. | pmid:12542530 |
| Koldamova RP et al. | 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. | 2003 | J. Biol. Chem. | pmid:12547833 |
| Goodwin B et al. | Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha. | 2003 | Mol. Endocrinol. | pmid:12554795 |
| Kocarek TA et al. | Use of dominant negative nuclear receptors to study xenobiotic-inducible gene expression in primary cultured hepatocytes. | 2002 May-Jun | J Pharmacol Toxicol Methods | pmid:12628309 |
| Gouédard C et al. | Opposite regulation of the human paraoxonase-1 gene PON-1 by fenofibrate and statins. | 2003 | Mol. Pharmacol. | pmid:12644596 |
| Cheng J et al. | The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory (StAR) protein expression. | 2003 | Toxicology | pmid:12699903 |
| Nguyen DH and Taub DD | Membrane incorporation of 22-hydroxycholesterol inhibits chemokine receptor activity. | 2003 | Exp. Cell Res. | pmid:12706121 |
| Denis M et al. | Expression, regulation, and activity of ABCA1 in human cell lines. | 2003 | Mol. Genet. Metab. | pmid:12706378 |
| Ide T et al. | Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling. | 2003 | Mol. Endocrinol. | pmid:12730332 |