MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.
To understand associated biological information of 22-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22-Hydroxycholesterol is suspected in Atherosclerosis, Fatty Streak, Arterial, Senile Plaques, Neurodegenerative Disorders, Coronary heart disease, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 22-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Bortnick AE et al. | Identification and characterization of rodent ABCA1 in isolated type II pneumocytes. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12909583 |
Kittayaruksakul S et al. | Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:22169006 |
Soodvilai S et al. | Liver X receptor agonists decrease ENaC-mediated sodium transport in collecting duct cells. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:23077096 |
Bates SR et al. | Expression and biological activity of ABCA1 in alveolar epithelial cells. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:17884990 |
Yoshida K et al. | Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats. | 2018 | Andrologia | pmid:28295471 |
Arikan S and Yigit AA | Effects of cholesterol and cAMP on progesterone production in cultured luteal cells isolated from pseudopregnant cat ovaries. | 2009 | Anim. Reprod. Sci. | pmid:19135321 |
Bosc MJ and Nicolle A | Androstenedione and progesterone production in vitro by the inner or the outer theca cells in preovulatory follicles of gonadotropin stimulated calves. | 1998 | Anim. Reprod. Sci. | pmid:9672665 |
El Roz A et al. | LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis. | 2012 | Anticancer Res. | pmid:22753765 |
Chuu CP and Lin HP | Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines. | 2010 | Anticancer Res. | pmid:20944148 |
Huang BM and Liu MY | Inhibitory actions of lead on steroidogenesis in MA-10 mouse Leydig tumor cells. | 2004 Jan-Feb | Arch. Androl. | pmid:14660163 |