| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
Total
2
22-Hydroxycholesterol
22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.
Cross Reference
Introduction
To understand associated biological information of 22-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 22-Hydroxycholesterol?
22-Hydroxycholesterol is suspected in Atherosclerosis, Fatty Streak, Arterial, Senile Plaques, Neurodegenerative Disorders, Coronary heart disease, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (2)
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Am. J. Physiol. Renal Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 22-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 22-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 22-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
- J. Biol. Chem. (3)
- Am. J. Physiol. Renal Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (9)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
- J. Biol. Chem. (3)
- J. Pharmacol. Exp. Ther. (1)
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Others (7)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 22-Hydroxycholesterol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 22-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Grochowski D and Szamatowicz M | [The role of gonadotropins, cyclic AMP, 22-R-OH-cholesterol and cofactors in regulating endocrine functions of the Leydig cells in rats. III. Mechanisms responsible for "desensitization" of the Leydig cells of rats caused by high doses of hCG]. | 1989 | Ginekol. Pol. | pmid:2561360 |
| Ceroi A et al. | The anti-inflammatory effects of platelet-derived microparticles in human plasmacytoid dendritic cells involve liver X receptor activation. | 2016 | Haematologica | pmid:26635040 |
| Yoon JH et al. | Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis. | 2004 | Hepatology | pmid:14999691 |
| Gupta V | Mineralocorticoid hypertension. | 2011 | Indian J Endocrinol Metab | pmid:22145132 |
| Patel MB et al. | Liver x receptor: a novel therapeutic target. | 2008 Mar-Apr | Indian J Pharm Sci | pmid:20046702 |
| Cacabelos R et al. | Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics. | 2012 | Int J Alzheimers Dis | pmid:22482072 |
| Salehipour M et al. | Polyunsaturated fatty acids and modulation of cholesterol homeostasis in THP-1 macrophage-derived foam cells. | 2010 | Int J Mol Sci | pmid:21151462 |
| Zhao SP et al. | Dual effects of oxidized low-density lipoprotein on LXR-ABCA1-apoA-I pathway in 3T3-L1 cells. | 2008 | Int. J. Cardiol. | pmid:17643522 |
| Norata GD et al. | Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells. | 2005 | Int. J. Mol. Med. | pmid:16142410 |
| Carter CJ | The Fox and the Rabbits-Environmental Variables and Population Genetics (1) Replication Problems in Association Studies and the Untapped Power of GWAS (2) Vitamin A Deficiency, Herpes Simplex Reactivation and Other Causes of Alzheimer's Disease. | 2011 | ISRN Neurol | pmid:22389816 |
| Noguchi N | Role of oxidative stress in adaptive responses in special reference to atherogenesis. | 2008 | J Clin Biochem Nutr | pmid:19015746 |
| López-Velázquez JA et al. | Nuclear receptors in nonalcoholic Fatty liver disease. | 2012 | J Lipids | pmid:22187655 |
| Kocarek TA et al. | Use of dominant negative nuclear receptors to study xenobiotic-inducible gene expression in primary cultured hepatocytes. | 2002 May-Jun | J Pharmacol Toxicol Methods | pmid:12628309 |
| Hedger MP and Eddy EM | Leydig cell cooperation in vitro: evidence for communication between adult rat Leydig cells. | 1990 Jan-Feb | J. Androl. | pmid:2155894 |
| Meikle AW et al. | Extracellular calcium and luteinizing hormone effects on 22-hydroxycholesterol used for testosterone production in mouse Leydig cells. | 1991 Mar-Apr | J. Androl. | pmid:2050582 |
| Wu CS et al. | Melatonin inhibits the expression of steroidogenic acute regulatory protein and steroidogenesis in MA-10 cells. | 2001 Mar-Apr | J. Androl. | pmid:11229798 |
| Sugano S et al. | Identification of intermediates in the conversion of cholesterol to pregnenolone with a reconstituted cytochrome p-450scc system: accumulation of the intermediate modulated by the adrenodoxin level. | 1996 | J. Biochem. | pmid:8947841 |
| Amemiya-Kudo M et al. | Suppression of the pancreatic duodenal homeodomain transcription factor-1 (Pdx-1) promoter by sterol regulatory element-binding protein-1c (SREBP-1c). | 2011 | J. Biol. Chem. | pmid:21652712 |
| Koldamova RP et al. | 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. | 2003 | J. Biol. Chem. | pmid:12547833 |
| Mast N et al. | Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. | 2011 | J. Biol. Chem. | pmid:21159775 |
| Fu X et al. | 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. | 2001 | J. Biol. Chem. | pmid:11504730 |
| Matsushita K et al. | Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha. | 2010 | J. Biol. Chem. | pmid:20118482 |
| Gan X et al. | Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate. | 2001 | J. Biol. Chem. | pmid:11641412 |
| Cupp JR and Vickery LE | Adrenodoxin with a COOH-terminal deletion (des 116-128) exhibits enhanced activity. | 1989 | J. Biol. Chem. | pmid:2912975 |
| Bowden K and Ridgway ND | OSBP negatively regulates ABCA1 protein stability. | 2008 | J. Biol. Chem. | pmid:18450749 |
| Landis MS et al. | Oxysterol activators of liver X receptor and 9-cis-retinoic acid promote sequential steps in the synthesis and secretion of tumor necrosis factor-alpha from human monocytes. | 2002 | J. Biol. Chem. | pmid:11741944 |
| Denis M et al. | Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1). | 2004 | J. Biol. Chem. | pmid:14660648 |
| Agassandian M et al. | Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:phosphocholine cytidylyltransferase. | 2005 | J. Biol. Chem. | pmid:15788406 |
| CHAUDHURI AC et al. | Biosynthesis of pregnenolone from 22-hydroxycholesterol. | 1962 | J. Biol. Chem. | pmid:13878470 |
| Fukumoto H et al. | Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels. | 2002 | J. Biol. Chem. | pmid:12384498 |
| Kaneko E et al. | Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist. | 2003 | J. Biol. Chem. | pmid:12847102 |
| Haidar B et al. | Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter. | 2004 | J. Biol. Chem. | pmid:14701824 |
| Costet P et al. | Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. | 2000 | J. Biol. Chem. | pmid:10858438 |
| Albers M et al. | A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors. | 2006 | J. Biol. Chem. | pmid:16354658 |
| Venugopal S et al. | Plasma Membrane Origin of the Steroidogenic Pool of Cholesterol Used in Hormone-induced Acute Steroid Formation in Leydig Cells. | 2016 | J. Biol. Chem. | pmid:27815506 |
| Sparrow CP et al. | A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux. | 2002 | J. Biol. Chem. | pmid:11790770 |
| Chuu CP et al. | Androgens as therapy for androgen receptor-positive castration-resistant prostate cancer. | 2011 | J. Biomed. Sci. | pmid:21859492 |
| Huwait EA et al. | Protein Kinase C Is Involved in the Induction of ATP-Binding Cassette Transporter A1 Expression by Liver X Receptor/Retinoid X Receptor Agonist in Human Macrophages. | 2015 | J. Cell. Biochem. | pmid:25752819 |
| Shouhed D et al. | Osteogenic oxysterols inhibit the adverse effects of oxidative stress on osteogenic differentiation of marrow stromal cells. | 2005 | J. Cell. Biochem. | pmid:15880703 |
| Jabara S et al. | Stromal cells of the human postmenopausal ovary display a distinctive biochemical and molecular phenotype. | 2003 | J. Clin. Endocrinol. Metab. | pmid:12519894 |
| Sokalska A et al. | Statins inhibit growth of human theca-interstitial cells in PCOS and non-PCOS tissues independently of cholesterol availability. | 2010 | J. Clin. Endocrinol. Metab. | pmid:20826585 |
| Escobar JC et al. | The human placenta expresses CYP17 and generates androgens de novo. | 2011 | J. Clin. Endocrinol. Metab. | pmid:21307141 |
| Honjo Y et al. | 1,25-dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptor. | 2006 | J. Endocrinol. | pmid:16522742 |
| Lin T et al. | Interleukin-1 inhibits Leydig cell steroidogenesis without affecting steroidogenic acute regulatory protein messenger ribonucleic acid or protein levels. | 1998 | J. Endocrinol. | pmid:9582502 |
| Ragoobir J et al. | Stimulation of progesterone production in human granulosa-lutein cells by lipoproteins: evidence for cholesterol-independent actions of high-density lipoproteins. | 2002 | J. Endocrinol. | pmid:11927389 |
| Joo SH et al. | Biosynthesis of a cholesterol-derived brassinosteroid, 28-norcastasterone, in Arabidopsis thaliana. | 2012 | J. Exp. Bot. | pmid:22170941 |
| Raccosta L et al. | The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. | 2013 | J. Exp. Med. | pmid:23897983 |
| Kömüves LG et al. | Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. | 2002 | J. Invest. Dermatol. | pmid:11851872 |
| Fowler AJ et al. | Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. | 2003 | J. Invest. Dermatol. | pmid:12542530 |
| Hong I et al. | LXRalpha enhances lipid synthesis in SZ95 sebocytes. | 2008 | J. Invest. Dermatol. | pmid:17960176 |