22-Hydroxycholesterol

22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.

Cross Reference

Introduction

To understand associated biological information of 22-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 22-Hydroxycholesterol?

22-Hydroxycholesterol is suspected in Atherosclerosis, Fatty Streak, Arterial, Senile Plaques, Neurodegenerative Disorders, Coronary heart disease, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 22-Hydroxycholesterol

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with 22-Hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 22-Hydroxycholesterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 22-Hydroxycholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 22-Hydroxycholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 22-Hydroxycholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 22-Hydroxycholesterol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 22-Hydroxycholesterol

Download all related citations
Per page 10 20 50 100 | Total 262
Authors Title Published Journal PubMed Link
Buono C et al. Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL. 2007 J. Lipid Res. pmid:17693624
Aghaloo TL et al. Oxysterols enhance osteoblast differentiation in vitro and bone healing in vivo. 2007 J. Orthop. Res. pmid:17568450
Yan D et al. Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17478758
Qiu G and Hill JS Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages. 2007 J. Lipid Res. pmid:17644777
Wang Y et al. Low concentrations mono-butyl phthalate stimulates steroidogenesis by facilitating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). 2006 Chem. Biol. Interact. pmid:16999944
Cheng S et al. Carbaryl inhibits basal and FSH-induced progesterone biosynthesis of primary human granulosa-lutein cells. 2006 Toxicology pmid:16413094
Yu CC and Li PH In vivo inhibition of steroidogenic acute regulatory protein expression by dexamethasone parallels induction of the negative transcription factor DAX-1. 2006 Endocrine pmid:17526944
Deng R et al. Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor. 2006 J. Pharmacol. Exp. Ther. pmid:16371446
Kase ET et al. 22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes. 2006 Biochim. Biophys. Acta pmid:17055780
Supornsilchai V et al. Sesquiterpene lactone helenalin suppresses Leydig and adrenocortical cell steroidogenesis by inhibiting expression of the steroidogenic acute regulatory protein. 2006 Reprod. Toxicol. pmid:16777379
Allen JA et al. Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis. 2006 Endocrinology pmid:16690799
Lee CS et al. Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor. 2006 Neuroreport pmid:16407768
Hassan HH et al. Cellular cholesterol homeostasis in vascular endothelial cells. 2006 Can J Cardiol pmid:16498511
Mazalli MR et al. HPLC method for quantification and characterization of cholesterol and its oxidation products in eggs. 2006 Lipids pmid:16981439
Honjo Y et al. 1,25-dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptor. 2006 J. Endocrinol. pmid:16522742
Albers M et al. A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors. 2006 J. Biol. Chem. pmid:16354658
Piraino G et al. Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. 2006 Shock pmid:16878022
Chen J et al. Effects of fenvalerate on progesterone production in cultured rat granulosa cells. 2005 Jul-Aug Reprod. Toxicol. pmid:15907653
Poon SL et al. Regulatory mechanism of Toona sinensis on mouse leydig cell steroidogenesis. 2005 Life Sci. pmid:15680312
Weedon-Fekjaer MS et al. Liver X receptors mediate inhibition of hCG secretion in a human placental trophoblast cell line. 2005 Placenta pmid:16226121
Shouhed D et al. Osteogenic oxysterols inhibit the adverse effects of oxidative stress on osteogenic differentiation of marrow stromal cells. 2005 J. Cell. Biochem. pmid:15880703
Chen JF et al. Effects of fenvalerate on steroidogenesis in cultured rat granulosa cells. 2005 Biomed. Environ. Sci. pmid:16001830
Norata GD et al. Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells. 2005 Int. J. Mol. Med. pmid:16142410
Yasuda T et al. Suppression of inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 22(R)-hydroxycholesterol requires de novo protein synthesis in activated macrophages. 2005 J. Steroid Biochem. Mol. Biol. pmid:16146692
Agassandian M et al. Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:phosphocholine cytidylyltransferase. 2005 J. Biol. Chem. pmid:15788406
Fluhr JW et al. Topical liver x receptor activators accelerate postnatal acidification of stratum corneum and improve function in the neonate. 2005 J. Invest. Dermatol. pmid:16354191
Hauet T et al. Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria. 2005 Mol. Endocrinol. pmid:15498831
Ou J et al. Effects of D-4F on vasodilation and vessel wall thickness in hypercholesterolemic LDL receptor-null and LDL receptor/apolipoprotein A-I double-knockout mice on Western diet. 2005 Circ. Res. pmid:16224061
Singh SB et al. Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. 2005 Bioorg. Med. Chem. Lett. pmid:15911262
Huang BM and Liu MY Inhibitory actions of lead on steroidogenesis in MA-10 mouse Leydig tumor cells. 2004 Jan-Feb Arch. Androl. pmid:14660163
Matyash V et al. Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16. 2004 PLoS Biol. pmid:15383841
Sriraman V and Jagannadha Rao A Evaluation of the role of FSH in regulation of Leydig cell function during different stages of its differentiation. 2004 Mol. Cell. Endocrinol. pmid:15353182
Huuskonen J et al. Role of p160 coactivator complex in the activation of liver X receptor. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:14764426
Lecanu L et al. Identification of naturally occurring spirostenols preventing beta-amyloid-induced neurotoxicity. 2004 Steroids pmid:14715372
Dubuc G et al. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15178557
Yoon JH et al. Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis. 2004 Hepatology pmid:14999691
Llaverias G et al. Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism. 2004 J. Lipid Res. pmid:15314095
Suzuki S et al. Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:14726413
Sato H et al. Oxysterol regulation of estrogen receptor alpha-mediated gene expression in a transcriptional activation assay system using HeLa cells. 2004 Biosci. Biotechnol. Biochem. pmid:15322366
Denis M et al. Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1). 2004 J. Biol. Chem. pmid:14660648
Schmuth M et al. The effect of LXR activators on AP-1 proteins in keratinocytes. 2004 J. Invest. Dermatol. pmid:15191540
Shenoy SD et al. CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor. 2004 Drug Metab. Dispos. pmid:14709622
Ishida BY et al. Regulated expression of apolipoprotein E by human retinal pigment epithelial cells. 2004 J. Lipid Res. pmid:14594998
Haidar B et al. Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter. 2004 J. Biol. Chem. pmid:14701824
O'Connell BJ et al. Cellular physiology of cholesterol efflux in vascular endothelial cells. 2004 Circulation pmid:15492319
Huang BM et al. Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium. 2004 Biol. Reprod. pmid:14711788
Field FJ et al. LXR/RXR ligand activation enhances basolateral efflux of beta-sitosterol in CaCo-2 cells. 2004 J. Lipid Res. pmid:14993242
Ando H et al. Effects of pravastatin on the expression of ATP-binding cassette transporter A1. 2004 J. Pharmacol. Exp. Ther. pmid:15210833
Krimbou L et al. Molecular interactions between apoE and ABCA1: impact on apoE lipidation. 2004 J. Lipid Res. pmid:14754908
Tang CK et al. Oxidized LDL upregulated ATP binding cassette transporter-1 in THP-1 macrophages. 2004 Acta Pharmacol. Sin. pmid:15132822