MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.
To understand associated biological information of 22-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22-Hydroxycholesterol is suspected in Atherosclerosis, Fatty Streak, Arterial, Senile Plaques, Neurodegenerative Disorders, Coronary heart disease, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 22-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Stocco DM et al. | The effects of hydrogen peroxide on steroidogenesis in mouse Leydig tumor cells. | 1993 | Endocrinology | pmid:8243310 |
Sourdaine P and Garnier DH | Stage-dependent modulation of Sertoli cell steroid production in dogfish (Scyliorhinus canicula). | 1993 | J. Reprod. Fertil. | pmid:8385221 |
Freeman DA et al. | Finasteride blocks progesterone synthesis in MA-10 Leydig tumor cells. | 1993 | Endocrinology | pmid:8404636 |
Musicki B et al. | Inhibition of protein synthesis and hormone-sensitive steroidogenesis in response to hydrogen peroxide in rat luteal cells. | 1994 | Endocrinology | pmid:7507829 |
Khanna A et al. | Heat shock protein induction blocks hormone-sensitive steroidogenesis in rat luteal cells. | 1994 | Steroids | pmid:8140601 |
Sun XR and Risbridger GP | Site of macrophage inhibition of luteinizing hormone-stimulated testosterone production by purified leydig cells. | 1994 | Biol. Reprod. | pmid:8142552 |
Picard-Hagen N et al. | Glucocorticoids enhance the cholesterol side-chain cleavage activity of ovine adrenocortical mitochondria. | 1995 | J. Steroid Biochem. Mol. Biol. | pmid:7577721 |
Brannian JD et al. | Hydrogen peroxide suppresses low-density lipoprotein (LDL) uptake and LDL-supported steroidogenesis by porcine luteal cells. | 1995 | Mol. Cell. Endocrinol. | pmid:7556884 |
Doris PA et al. | Ouabain production by cultured adrenal cells. | 1996 | Endocrinology | pmid:8593799 |
Pezzi V et al. | Role of calmodulin-dependent protein kinase II in the acute stimulation of aldosterone production. | 1996 | J. Steroid Biochem. Mol. Biol. | pmid:8903426 |