| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
Total
2
22-Hydroxycholesterol
22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.
Cross Reference
Introduction
To understand associated biological information of 22-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 22-Hydroxycholesterol?
22-Hydroxycholesterol is suspected in Atherosclerosis, Fatty Streak, Arterial, Senile Plaques, Neurodegenerative Disorders, Coronary heart disease, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (2)
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Am. J. Physiol. Renal Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 22-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 22-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 22-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
- J. Biol. Chem. (3)
- J. Pharmacol. Exp. Ther. (1)
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Others (7)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 22-Hydroxycholesterol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 22-Hydroxycholesterol
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| CHAUDHURI AC et al. | Biosynthesis of pregnenolone from 22-hydroxycholesterol. | 1962 | J. Biol. Chem. | pmid:13878470 |
| Ishida BY et al. | Regulated expression of apolipoprotein E by human retinal pigment epithelial cells. | 2004 | J. Lipid Res. | pmid:14594998 |
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| Lecanu L et al. | Identification of naturally occurring spirostenols preventing beta-amyloid-induced neurotoxicity. | 2004 | Steroids | pmid:14715372 |
| Suzuki S et al. | Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14726413 |
| Krimbou L et al. | Molecular interactions between apoE and ABCA1: impact on apoE lipidation. | 2004 | J. Lipid Res. | pmid:14754908 |
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| Field FJ et al. | LXR/RXR ligand activation enhances basolateral efflux of beta-sitosterol in CaCo-2 cells. | 2004 | J. Lipid Res. | pmid:14993242 |
| Yoon JH et al. | Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis. | 2004 | Hepatology | pmid:14999691 |
| Tang CK et al. | Oxidized LDL upregulated ATP binding cassette transporter-1 in THP-1 macrophages. | 2004 | Acta Pharmacol. Sin. | pmid:15132822 |
| Dubuc G et al. | Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15178557 |
| Schmuth M et al. | The effect of LXR activators on AP-1 proteins in keratinocytes. | 2004 | J. Invest. Dermatol. | pmid:15191540 |
| Ando H et al. | Effects of pravastatin on the expression of ATP-binding cassette transporter A1. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15210833 |
| Tomita M et al. | Effect of 22R-hydroxycholesterol on the action of sphingomyelinase from Bacillus cereus toward bovine erythrocytes. | 1992 | Toxicon | pmid:1523674 |