| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
Total
2
22-Hydroxycholesterol
22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.
Cross Reference
Introduction
To understand associated biological information of 22-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 22-Hydroxycholesterol?
22-Hydroxycholesterol is suspected in Atherosclerosis, Fatty Streak, Arterial, Senile Plaques, Neurodegenerative Disorders, Coronary heart disease, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (2)
- J. Pharmacol. Exp. Ther. (1)
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 22-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 22-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 22-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
- J. Biol. Chem. (3)
- Am. J. Physiol. Renal Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (9)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 22-Hydroxycholesterol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 22-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yao ZX et al. | 22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. | 2007 | Neuroscience | pmid:17689017 |
| Kase ET et al. | Liver X receptor antagonist reduces lipid formation and increases glucose metabolism in myotubes from lean, obese and type 2 diabetic individuals. | 2007 | Diabetologia | pmid:17661008 |
| Saldanha T and Bragagnolo N | Cholesterol oxidation is increased and PUFA decreased by frozen storage and grilling of Atlantic hake fillets (Merluccius hubbsi). | 2007 | Lipids | pmid:17492472 |
| Yan D et al. | Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17478758 |
| Wang Y et al. | Low concentrations mono-butyl phthalate stimulates steroidogenesis by facilitating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). | 2006 | Chem. Biol. Interact. | pmid:16999944 |
| Cheng S et al. | Carbaryl inhibits basal and FSH-induced progesterone biosynthesis of primary human granulosa-lutein cells. | 2006 | Toxicology | pmid:16413094 |
| Yu CC and Li PH | In vivo inhibition of steroidogenic acute regulatory protein expression by dexamethasone parallels induction of the negative transcription factor DAX-1. | 2006 | Endocrine | pmid:17526944 |
| Deng R et al. | Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16371446 |
| Kase ET et al. | 22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes. | 2006 | Biochim. Biophys. Acta | pmid:17055780 |
| Supornsilchai V et al. | Sesquiterpene lactone helenalin suppresses Leydig and adrenocortical cell steroidogenesis by inhibiting expression of the steroidogenic acute regulatory protein. | 2006 | Reprod. Toxicol. | pmid:16777379 |
| Allen JA et al. | Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis. | 2006 | Endocrinology | pmid:16690799 |
| Lee CS et al. | Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor. | 2006 | Neuroreport | pmid:16407768 |
| Hassan HH et al. | Cellular cholesterol homeostasis in vascular endothelial cells. | 2006 | Can J Cardiol | pmid:16498511 |
| Mazalli MR et al. | HPLC method for quantification and characterization of cholesterol and its oxidation products in eggs. | 2006 | Lipids | pmid:16981439 |
| Honjo Y et al. | 1,25-dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptor. | 2006 | J. Endocrinol. | pmid:16522742 |
| Albers M et al. | A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors. | 2006 | J. Biol. Chem. | pmid:16354658 |
| Piraino G et al. | Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. | 2006 | Shock | pmid:16878022 |
| Chen J et al. | Effects of fenvalerate on progesterone production in cultured rat granulosa cells. | 2005 Jul-Aug | Reprod. Toxicol. | pmid:15907653 |
| Agassandian M et al. | Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:phosphocholine cytidylyltransferase. | 2005 | J. Biol. Chem. | pmid:15788406 |
| Ou J et al. | Effects of D-4F on vasodilation and vessel wall thickness in hypercholesterolemic LDL receptor-null and LDL receptor/apolipoprotein A-I double-knockout mice on Western diet. | 2005 | Circ. Res. | pmid:16224061 |