| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
Total
2
22-Hydroxycholesterol
22-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22-hydroxycholesterol is associated with abnormalities such as Hypertensive disease, Cardiovascular Diseases, Congestive heart failure, Atherosclerosis and Hypercholesterolemia. The involved functions are known as physiological aspects, Regulation, Anabolism, Metabolic Inhibition and Adjudication. 22-hydroxycholesterol often locates in Body tissue, Blood, Mitochondria, Membrane and Tissue membrane. The associated genes with 22-Hydroxycholesterol are Candidate Disease Gene, ABCA1 gene, CLTC gene, SLC22A1 gene and SLC10A1 gene. The related lipids are Hydroxycholesterols, Lipopolysaccharides, 22-hydroxycholesterol, Fatty Acids and (22R)-22-hydroxycholesterol.
Cross Reference
Introduction
To understand associated biological information of 22-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 22-Hydroxycholesterol?
22-Hydroxycholesterol is suspected in Atherosclerosis, Fatty Streak, Arterial, Senile Plaques, Neurodegenerative Disorders, Coronary heart disease, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (2)
- J. Pharmacol. Exp. Ther. (1)
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 22-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 22-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 22-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
- J. Biol. Chem. (3)
- Am. J. Physiol. Renal Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (9)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 22-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 22-Hydroxycholesterol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 22-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hynynen R et al. | OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. | 2009 | J. Lipid Res. | pmid:19224871 |
| Hong C et al. | Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. | 2011 | J. Lipid Res. | pmid:21187453 |
| Murthy S et al. | LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells. | 2002 | J. Lipid Res. | pmid:12091489 |
| Ishida BY et al. | Regulated expression of apolipoprotein E by human retinal pigment epithelial cells. | 2004 | J. Lipid Res. | pmid:14594998 |
| Honda A et al. | Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. | 2009 | J. Lipid Res. | pmid:18815436 |
| Buono C et al. | Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL. | 2007 | J. Lipid Res. | pmid:17693624 |
| Kaplan R et al. | Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway. | 2002 | J. Lipid Res. | pmid:12032171 |
| Qiu G and Hill JS | Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages. | 2007 | J. Lipid Res. | pmid:17644777 |
| Wellington CL et al. | Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol. | 2002 | J. Lipid Res. | pmid:12401893 |
| Spencer TA et al. | Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. | 2001 | J. Med. Chem. | pmid:11300870 |
| Saito Y et al. | Lysis of platelets and erythrocytes by the incorporation of a unique oxygenated sterol: 22R-hydroxycholesterol. | 1985 | J. Membr. Biol. | pmid:3999118 |
| Wang M et al. | Molecular determinants of LXRalpha agonism. | 2003 | J. Mol. Graph. Model. | pmid:12932788 |
| Kotani H et al. | Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor. | 2010 | J. Nat. Prod. | pmid:20695472 |
| Yao ZX et al. | 22R-Hydroxycholesterol protects neuronal cells from beta-amyloid-induced cytotoxicity by binding to beta-amyloid peptide. | 2002 | J. Neurochem. | pmid:12437582 |
| Papadopoulos V and Lecanu L | Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties. | 2012 | J. Neuroendocrinol. | pmid:21623958 |
| Minagawa H et al. | Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture. | 2009 | J. Neurosci. Res. | pmid:19326444 |
| Aghaloo TL et al. | Oxysterols enhance osteoblast differentiation in vitro and bone healing in vivo. | 2007 | J. Orthop. Res. | pmid:17568450 |
| Na TY et al. | 22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. | 2015 | J. Pathol. | pmid:25557254 |
| Deng R et al. | Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16371446 |
| Ando H et al. | Effects of pravastatin on the expression of ATP-binding cassette transporter A1. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15210833 |