26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.
To understand associated biological information of 26-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
26-Hydroxycholesterol is suspected in hypercholesterolemia, Obesity, Atherosclerosis, Metabolic syndrome, Neurodegenerative Disorders, Dyslipidemias and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 26-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cholesterol and breast cancer pathophysiology.' (Nelson ER et al., 2014) and Transgenic Model are used in the study 'Obesity, cholesterol metabolism, and breast cancer pathogenesis.' (McDonnell DP et al., 2014).
Knock-out are used in the study 'The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.' (Umetani M et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tuomainen TP et al. | Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man. | 2003 | Free Radic. Biol. Med. | pmid:14556856 |
| Lee CY et al. | Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample. | 2008 | Free Radic. Biol. Med. | pmid:18226605 |
| Seet RC et al. | Oxidative damage in dengue fever. | 2009 | Free Radic. Biol. Med. | pmid:19427377 |
| Riendeau V and Garenc C | Effect of 27-hydroxycholesterol on survival and death of human macrophages and vascular smooth muscle cells. | 2009 | Free Radic. Res. | pmid:19672739 |
| Virginio VW et al. | Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity. | 2015 | Free Radic. Res. | pmid:25465091 |
| Salomone S and Waeber C | Selectivity and specificity of sphingosine-1-phosphate receptor ligands: caveats and critical thinking in characterizing receptor-mediated effects. | 2011 | Front Pharmacol | pmid:21687504 |
| Wolf A et al. | ABC Transporters and the Alzheimer's Disease Enigma. | 2012 | Front Psychiatry | pmid:22675311 |
| Javitt NB | Cholic acid synthesis from 27-hydroxycholesterol in humans. | 1998 | Gastroenterology | pmid:9758543 |
| Arnon R et al. | Cholesterol 7-hydroxylase knockout mouse: a model for monohydroxy bile acid-related neonatal cholestasis. | 1998 | Gastroenterology | pmid:9797378 |
| Bieghs V et al. | The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice. | 2013 | Gastroenterology | pmid:23041327 |
| Hirayama T et al. | Serum concentration of 27-hydroxycholesterol predicts the effects of high-cholesterol diet on plasma LDL cholesterol level. | 2009 | Hepatol. Res. | pmid:19208035 |
| Pandak WM et al. | Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. | 2002 | Hepatology | pmid:12029625 |
| Goldman M et al. | Bile acid metabolism in cirrhosis. VIII. Quantitative evaluation of bile acid synthesis from [7 beta-3H]7 alpha-hydroxycholesterol and [G-3H]26-hydroxycholesterol. | 1982 Jan-Feb | Hepatology | pmid:7054068 |
| Bertolotti M et al. | Suppression of bile acid synthesis, but not of hepatic cholesterol 7alpha-hydroxylase expression, by obstructive cholestasis in humans. | 2001 | Hepatology | pmid:11481606 |
| Patel MB et al. | Liver x receptor: a novel therapeutic target. | 2008 Mar-Apr | Indian J Pharm Sci | pmid:20046702 |
| Schreurs BG et al. | Dietary Cholesterol Concentration and Duration Degrade Long-Term Memory of Classical Conditioning of the Rabbit's Nictitating Membrane Response. | 2012 | Int J Alzheimers Dis | pmid:22567532 |
| Ferreiro E et al. | Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers. | 2012 | Int J Cell Biol | pmid:22701485 |
| Lütjohann D et al. | 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man. | 2009 | Int J Clin Pharmacol Ther | pmid:19954708 |
| Freemantle E et al. | Analysis of oxysterols and cholesterol in prefrontal cortex of suicides. | 2013 | Int. J. Neuropsychopharmacol. | pmid:23369504 |
| Mast N et al. | Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:20881306 |
| Vini R et al. | Evidence of pomegranate methanolic extract in antagonizing the endogenous SERM, 27-hydroxycholesterol. | 2016 | IUBMB Life | pmid:26756990 |
| Kou IL et al. | Influence of 26-hydroxycholesterol on the composition and function of gel-filtered platelets. | 1991 | J Am Coll Nutr | pmid:2030252 |
| Hojo K et al. | Determination of total cholesterol in serum by high-performance liquid chromatography with electrochemical detection. | 2007 | J Chromatogr A | pmid:17723233 |
| Pataj Z et al. | Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. | 2016 | J Chromatogr A | pmid:26607314 |
| Thelen KM et al. | High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels. | 2006 | J Clin Pharmacol | pmid:16809807 |
| Ebrahimi KB and Handa JT | Lipids, lipoproteins, and age-related macular degeneration. | 2011 | J Lipids | pmid:21822496 |
| López-Velázquez JA et al. | Nuclear receptors in nonalcoholic Fatty liver disease. | 2012 | J Lipids | pmid:22187655 |
| Cohen E et al. | Increased Levels of Human Carotid Lesion Linoleic Acid Hydroperoxide in Symptomatic and Asymptomatic Patients Is Inversely Correlated with Serum HDL and Paraoxonase 1 Activity. | 2012 | J Lipids | pmid:22690338 |
| Li T and Chiang JY | Bile Acid signaling in liver metabolism and diseases. | 2012 | J Lipids | pmid:21991404 |
| Siam A et al. | Comparative modeling of 25-hydroxycholesterol-7α-hydroxylase (CYP7B1): ligand binding and analysis of hereditary spastic paraplegia type 5 CYP7B1 mutations. | 2012 | J Mol Model | pmid:21541746 |
| Vejux A et al. | Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments. | 2011 | J Ophthalmol | pmid:21577274 |
| DiBlasio-Smith EA et al. | Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. | 2008 | J Transl Med | pmid:18925943 |
| Ghribi O | Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle. | 2008 | J. Alzheimers Dis. | pmid:19096164 |
| Mateos L et al. | Upregulation of brain renin angiotensin system by 27-hydroxycholesterol in Alzheimer's disease. | 2011 | J. Alzheimers Dis. | pmid:21297254 |
| Marwarha G et al. | Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. | 2010 | J. Alzheimers Dis. | pmid:20157255 |
| Wang HL et al. | Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis. | 2016 | J. Alzheimers Dis. | pmid:26836015 |
| Hughes TM et al. | Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's disease. | 2012 | J. Alzheimers Dis. | pmid:22377780 |
| Kim WS et al. | Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons. | 2009 | J. Alzheimers Dis. | pmid:19158428 |
| Brooks SW et al. | A High-Cholesterol Diet Increases 27-Hydroxycholesterol and Modifies Estrogen Receptor Expression and Neurodegeneration in Rabbit Hippocampus. | 2017 | J. Alzheimers Dis. | pmid:27911307 |
| Oyama T et al. | Effect of deposited lipids in atheromatous lesions on the migration of vascular smooth muscle cells. | 2002 | J. Atheroscler. Thromb. | pmid:12236314 |
| Szedlacsek SE et al. | Esterification of oxysterols by human plasma lecithin-cholesterol acyltransferase. | 1995 | J. Biol. Chem. | pmid:7744831 |
| Bodin K et al. | Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4. | 2001 | J. Biol. Chem. | pmid:11514559 |
| Norlin M et al. | Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A). | 2000 | J. Biol. Chem. | pmid:10882719 |
| Pandak WM et al. | Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes. | 2002 | J. Biol. Chem. | pmid:12368294 |
| Li-Hawkins J et al. | Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. | 2000 | J. Biol. Chem. | pmid:10748047 |
| Frolov A et al. | NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols. | 2003 | J. Biol. Chem. | pmid:12719428 |
| Davies JD et al. | Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells. | 2005 | J. Biol. Chem. | pmid:15548517 |
| Brown J et al. | Differential expression of cholesterol hydroxylases in Alzheimer's disease. | 2004 | J. Biol. Chem. | pmid:15148325 |
| Axelson M and Larsson O | Low density lipoprotein (LDL) cholesterol is converted to 27-hydroxycholesterol in human fibroblasts. Evidence that 27-hydroxycholesterol can be an important intracellular mediator between LDL and the suppression of cholesterol production. | 1995 | J. Biol. Chem. | pmid:7797494 |
| Escher G et al. | Expression of sterol 27-hydroxylase (CYP27A1) enhances cholesterol efflux. | 2003 | J. Biol. Chem. | pmid:12531903 |