26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.
To understand associated biological information of 26-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
26-Hydroxycholesterol is suspected in hypercholesterolemia, Obesity, Atherosclerosis, Metabolic syndrome, Neurodegenerative Disorders, Dyslipidemias and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 26-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcoholism | D000437 | 27 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Transgenic Model are used in the study 'Cholesterol and breast cancer pathophysiology.' (Nelson ER et al., 2014) and Transgenic Model are used in the study 'Obesity, cholesterol metabolism, and breast cancer pathogenesis.' (McDonnell DP et al., 2014).
Knock-out are used in the study 'The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.' (Umetani M et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Souidi M et al. | Effects of dietary 27-hydroxycholesterol on cholesterol metabolism and bile acid biosynthesis in the hamster. | 2003 | Can. J. Physiol. Pharmacol. | pmid:14614521 |
| Zhang J et al. | The steroidal analog GW707 activates the SREBP pathway through disruption of intracellular cholesterol trafficking. | 2004 | J. Lipid Res. | pmid:14617742 |
| Pikuleva I and Javitt NB | Novel sterols synthesized via the CYP27A1 metabolic pathway. | 2003 | Arch. Biochem. Biophys. | pmid:14622972 |
| Ciuffreda P et al. | Synthesis of deuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids. | 2003 | Steroids | pmid:14625005 |
| Strömsten A et al. | Studies on the mechanism of accumulation of cholesterol in the gallbladder mucosa. Evidence that sterol 27-hydroxylase is not a pathogenetic factor. | 2004 | J. Hepatol. | pmid:14672608 |
| Honda A et al. | Significance of plasma 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits. | 2004 | Metab. Clin. Exp. | pmid:14681840 |
| Guan JZ et al. | Clofibrate, a peroxisome-proliferator, enhances reverse cholesterol transport through cytochrome P450 activation and oxysterol generation. | 2003 | Tohoku J. Exp. Med. | pmid:14690017 |
| Burkard I et al. | Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry. | 2004 | J. Lipid Res. | pmid:14729854 |
| Leoni V et al. | Diagnostic use of cerebral and extracerebral oxysterols. | 2004 | Clin. Chem. Lab. Med. | pmid:15061359 |
| Brown J et al. | Differential expression of cholesterol hydroxylases in Alzheimer's disease. | 2004 | J. Biol. Chem. | pmid:15148325 |
| Zhou Q et al. | 27-Hydroxycholesterol inhibits neutral sphingomyelinase in cultured human endothelial cells. | 2004 | Life Sci. | pmid:15261762 |
| Szanto A et al. | Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophages. | 2004 | Mol. Cell. Biol. | pmid:15340076 |
| Holdenrieder S et al. | Does brain specific 24S-hydroxycholesterol in plasma indicate the disruption of the blood-brain barrier in patients with ischemic stroke? | 2004 | Neurosci. Lett. | pmid:15351449 |
| Kölsch H et al. | Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients. | 2004 | Neurosci. Lett. | pmid:15364416 |
| Matyash V et al. | Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16. | 2004 | PLoS Biol. | pmid:15383841 |
| Meaney S et al. | Serum cholestenoic acid as a potential marker of pulmonary cholesterol homeostasis: increased levels in patients with pulmonary alveolar proteinosis. | 2004 | J. Lipid Res. | pmid:15466366 |
| Davies JD et al. | Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells. | 2005 | J. Biol. Chem. | pmid:15548517 |
| Alessandrini L et al. | Clemmensen reduction of diosgenin and kryptogenin: synthesis of [16,16,22,22,23,23-(2)H(6)]-(25R)-26-hydroxycholesterol. | 2004 | Steroids | pmid:15582533 |
| Hansson M et al. | Regulation of sterol 27-hydroxylase in human monocyte-derived macrophages: up-regulation by transforming growth factor beta1. | 2005 | Biochim. Biophys. Acta | pmid:15708352 |
| Heverin M et al. | Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain. | 2005 | J. Lipid Res. | pmid:15741649 |
| von Bahr S et al. | Mutation in the sterol 27-hydroxylase gene associated with fatal cholestasis in infancy. | 2005 | J. Pediatr. Gastroenterol. Nutr. | pmid:15795599 |
| Del Puppo M et al. | A minimally invasive technique for the evaluation of the regulatory steps of the two major pathways of bile acid synthesis. | 2005 | Clin. Chim. Acta | pmid:15820474 |
| Hall EA et al. | Detection of the steroidogenic acute regulatory protein, StAR, in human liver cells. | 2005 | Biochim. Biophys. Acta | pmid:15863358 |
| Bohr IJ | Does cholesterol act as a protector of cholinergic projections in Alzheimer's disease? | 2005 | Lipids Health Dis | pmid:15949039 |
| Meaney S | Is C-26 hydroxylation an evolutionarily conserved steroid inactivation mechanism? | 2005 | FASEB J. | pmid:16051688 |
| Babiker A et al. | Patients with atherosclerosis may have increased circulating levels of 27-hydroxycholesterol and cholestenoic acid. | 2005 | Scand. J. Clin. Lab. Invest. | pmid:16081359 |
| Zhu Y et al. | Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR). | 2005 | Cardiovasc. Res. | pmid:16099444 |
| Lemaire-Ewing S et al. | Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. | 2005 | Cell Biol. Toxicol. | pmid:16142584 |
| Kummerow FA et al. | 27-Hydroxycholesterol causes remodeling in endothelial cell membrane lipid composition comparable to remodeling in the failed vein grafts of CABG patients. | 2006 | Life Sci. | pmid:16154158 |
| Guéguen Y et al. | Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat. | 2006 | Arch. Toxicol. | pmid:16231126 |
| Pinkerton FD et al. | Synergistic action of two oxysterols in the lowering of HMG-CoA reductase activity in CHO-K1 cells. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1632792 |
| Thelen KM et al. | Effect of pravastatin on plasma sterols and oxysterols in men. | 2006 | Eur. J. Clin. Pharmacol. | pmid:16385401 |
| Pikuleva IA | Cholesterol-metabolizing cytochromes P450. | 2006 | Drug Metab. Dispos. | pmid:16434543 |
| Hall EA et al. | Mitochondrial cholesterol transport: a possible target in the management of hyperlipidemia. | 2005 | Lipids | pmid:16477808 |
| Klass DM et al. | Biliary lipids, cholesterol and bile synthesis: different adaptive mechanisms to dietary cholesterol in lean and obese subjects. | 2006 | Aliment. Pharmacol. Ther. | pmid:16573792 |
| Gong H and Williams JR | Synthesis of the aglycone of the shark repellent pavoninin-4 using remote functionalization. | 2006 | Org. Lett. | pmid:16706499 |
| Thelen KM et al. | High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels. | 2006 | J Clin Pharmacol | pmid:16809807 |
| Björkhem I et al. | Oxysterols and Alzheimer's disease. | 2006 | Acta Neurol. Scand., Suppl.c | pmid:16866910 |
| Larsson DA et al. | Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects. | 2006 | Free Radic. Biol. Med. | pmid:16934673 |
| Holzapfel J et al. | PPARD haplotype influences cholesterol metabolism but is no risk factor of Alzheimer's disease. | 2006 | Neurosci. Lett. | pmid:16979821 |
| Dushkin MI et al. | Effects of hydroxysterols and atorvastatin on lipopolysaccharide-induced secretion of tumor necrosis factor and interleukin-10 by mouse macrophages. | 2006 | Bull. Exp. Biol. Med. | pmid:16984105 |
| Luomala M et al. | Plasma-soluble CD40 is related to cholesterol metabolism in patients with moderate hypercholesterolemia. | 2006 | Scand. Cardiovasc. J. | pmid:17012138 |
| Rojo L et al. | Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease. | 2006 | J. Biomed. Biotechnol. | pmid:17047312 |
| Li T et al. | PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. | 2007 | J. Lipid Res. | pmid:17088262 |
| Burkard I et al. | Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers. | 2007 | Atherosclerosis | pmid:17107679 |
| Björkhem I | Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain. | 2006 | J. Intern. Med. | pmid:17116000 |
| Jiang X et al. | Characterization of oxysterols by electrospray ionization tandem mass spectrometry after one-step derivatization with dimethylglycine. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17154356 |
| Chen W et al. | Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. | 2007 | Cell Metab. | pmid:17189208 |
| Meaney S et al. | Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7alpha-hydroxy-3-oxo-4-cholestenoic acid. | 2007 | J. Lipid Res. | pmid:17251592 |
| Toll A et al. | 7 alpha-hydroxylation of 26-hydroxycholesterol, 3 beta-hydroxy-5-cholestenoic acid and 3 beta-hydroxy-5-cholenoic acid by cytochrome P-450 in pig liver microsomes. | 1992 | FEBS Lett. | pmid:1730295 |