26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.
To understand associated biological information of 26-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
26-Hydroxycholesterol is suspected in hypercholesterolemia, Obesity, Atherosclerosis, Metabolic syndrome, Neurodegenerative Disorders, Dyslipidemias and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 26-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cholesterol and breast cancer pathophysiology.' (Nelson ER et al., 2014) and Transgenic Model are used in the study 'Obesity, cholesterol metabolism, and breast cancer pathogenesis.' (McDonnell DP et al., 2014).
Knock-out are used in the study 'The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.' (Umetani M et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Leoni V and Caccia C | Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid. | 2013 | Biochem. Pharmacol. | pmid:23541982 |
| Baker ME | Insights from the structure of estrogen receptor into the evolution of estrogens: implications for endocrine disruption. | 2011 | Biochem. Pharmacol. | pmid:21420388 |
| Ragot K et al. | Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes. | 2013 | Biochem. Pharmacol. | pmid:23473804 |
| Zhang J et al. | Studies on the relationships between 7 alpha-hydroxylation and the ability of 25- and 27-hydroxycholesterol to suppress the activity of HMG-CoA reductase. | 1997 | Biochim. Biophys. Acta | pmid:9059514 |
| Kim SM et al. | 27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide. | 2015 | Biochim. Biophys. Acta | pmid:25497142 |
| Kölsch H et al. | Alterations of cholesterol precursor levels in Alzheimer's disease. | 2010 | Biochim. Biophys. Acta | pmid:20226877 |
| Javitt NB | Biologic role(s) of the 25(R),26-hydroxycholesterol metabolic pathway. | 2000 | Biochim. Biophys. Acta | pmid:11111083 |
| Zhang J et al. | 7 alpha-Hydroxylation of 25-hydroxycholesterol and 27-hydroxycholesterol in human fibroblasts. | 1995 | Biochim. Biophys. Acta | pmid:7786899 |
| Tang W et al. | Glucocorticoid receptor-mediated upregulation of human CYP27A1, a potential anti-atherogenic enzyme. | 2008 Nov-Dec | Biochim. Biophys. Acta | pmid:18817892 |
| Crow JA et al. | Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. | 2010 | Biochim. Biophys. Acta | pmid:19761868 |
| Sauter G et al. | Formation of cholic acid and chenodeoxycholic acid from 7 alpha-hydroxycholesterol and 27-hydroxycholesterol by primary cultures of human hepatocytes. | 1996 | Biochim. Biophys. Acta | pmid:8608157 |
| Carpenter KL et al. | Lipids and oxidised lipids in human atheroma and normal aorta. | 1993 | Biochim. Biophys. Acta | pmid:8466938 |
| Hall EA et al. | Detection of the steroidogenic acute regulatory protein, StAR, in human liver cells. | 2005 | Biochim. Biophys. Acta | pmid:15863358 |
| Hansson M et al. | Regulation of sterol 27-hydroxylase in human monocyte-derived macrophages: up-regulation by transforming growth factor beta1. | 2005 | Biochim. Biophys. Acta | pmid:15708352 |
| Hansson M et al. | Marked induction of sterol 27-hydroxylase activity and mRNA levels during differentiation of human cultured monocytes into macrophages. | 2003 | Biochim. Biophys. Acta | pmid:12581873 |
| Russell DW | Oxysterol biosynthetic enzymes. | 2000 | Biochim. Biophys. Acta | pmid:11111082 |
| Carpenter KL et al. | Lipids and oxidised lipids in human atherosclerotic lesions at different stages of development. | 1995 | Biochim. Biophys. Acta | pmid:7766691 |
| Javitt NB et al. | Rapid synthesis of 26-hydroxycholesterol from mevalonic acid in the Syrian hamster. | 1984 | Biochim. Biophys. Acta | pmid:6733127 |
| FREDRICKSON DS and ONO K | The in vitro production of 25- and 26-hydroxycholesterol and their in vivo metabolism. | 1956 | Biochim. Biophys. Acta | pmid:13373861 |
| Björkhem I et al. | 7 alpha-hydroxylation of 27-hydroxycholesterol in human liver microsomes. | 1992 | Biochim. Biophys. Acta | pmid:1390879 |
| Babiker A and Diczfalusy U | Transport of side-chain oxidized oxysterols in the human circulation. | 1998 | Biochim. Biophys. Acta | pmid:9630709 |
| Hasan SQ and Kushwaha RS | Differences in 27-hydroxycholesterol concentrations in plasma and liver of baboons with high and low responses to dietary cholesterol and fat. | 1993 | Biochim. Biophys. Acta | pmid:8399364 |
| Li S et al. | Kinetics and plasma concentrations of 26-hydroxycholesterol in baboons. | 2000 | Biochim. Biophys. Acta | pmid:10832098 |
| Lund E et al. | 24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver. | 1993 | Biochim. Biophys. Acta | pmid:8443234 |
| Crisby M et al. | Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques. | 1997 | Biochim. Biophys. Acta | pmid:9059518 |
| Norlin M and Wikvall K | Biochemical characterization of the 7alpha-hydroxylase activities towards 27-hydroxycholesterol and dehydroepiandrosterone in pig liver microsomes. | 1998 | Biochim. Biophys. Acta | pmid:9487148 |
| Ma D et al. | ApoA-I or ABCA1 expression suppresses fatty acid synthesis by reducing 27-hydroxycholesterol levels. | 2014 | Biochimie | pmid:24793484 |
| Marengo B et al. | Oxysterol mixture and, in particular, 27-hydroxycholesterol drive M2 polarization of human macrophages. | Biofactors | pmid:26669587 | |
| Bogan RL et al. | Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. | 2012 | Biol. Reprod. | pmid:22156476 |
| Javitt NB et al. | Cholest-5-ene-3 beta, 26-diol: synthesis and biomedical use of a deuterated compound. | 1982 | Biomed. Mass Spectrom. | pmid:7059660 |
| Desmarchelier C et al. | C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia. | 2012 | BMC Genomics | pmid:22394543 |
| van den Bosch HM et al. | Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting. | 2007 | BMC Genomics | pmid:17683626 |
| Mosig S et al. | Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism. | 2008 | BMC Med Genomics | pmid:19040724 |
| Bandaru VV and Haughey NJ | Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum. | 2014 | BMC Neurosci | pmid:25539717 |
| Dasari B et al. | The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. | 2010 | BMC Ophthalmol | pmid:20836858 |
| Dasari B et al. | Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina. | 2011 | BMC Ophthalmol | pmid:21851605 |
| Winkler BS et al. | Maternal 27-hydroxycholesterol concentrations during the course of pregnancy and in pregnancy pathologies. | 2017 | BMC Pregnancy Childbirth | pmid:28376740 |
| Poirier J et al. | High-dose supplemental selenite to male Syrian hamsters fed hypercholesterolaemic diets alters Ldlr, Abcg8 and Npc1l1 mRNA expression and lowers plasma cholesterol concentrations. | 2012 | Br. J. Nutr. | pmid:22152646 |
| Schöls L et al. | Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial. | 2017 | Brain | pmid:29126212 |
| Weiner MF et al. | Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury. | 2008 | Brain Inj | pmid:18568715 |
| Mateos L et al. | Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro. | 2009 | Brain Pathol. | pmid:18503570 |
| Saint-Pol J et al. | Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells. | 2013 | Brain Res. | pmid:23603412 |
| Dushkin MI et al. | Effects of hydroxysterols and atorvastatin on lipopolysaccharide-induced secretion of tumor necrosis factor and interleukin-10 by mouse macrophages. | 2006 | Bull. Exp. Biol. Med. | pmid:16984105 |
| Souidi M et al. | Effects of dietary 27-hydroxycholesterol on cholesterol metabolism and bile acid biosynthesis in the hamster. | 2003 | Can. J. Physiol. Pharmacol. | pmid:14614521 |
| Cholesterol metabolite linked to breast cancer. | 2014 | Cancer Discov | pmid:24596219 | |
| McDonnell DP et al. | Obesity, cholesterol metabolism, and breast cancer pathogenesis. | 2014 | Cancer Res. | pmid:25060521 |
| Alfaqih MA et al. | CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. | 2017 | Cancer Res. | pmid:28130224 |
| Taylor JM et al. | Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI. | 2010 | Cardiovasc. Res. | pmid:20083572 |
| Zhu Y et al. | Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR). | 2005 | Cardiovasc. Res. | pmid:16099444 |
| Lemaire-Ewing S et al. | Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. | 2005 | Cell Biol. Toxicol. | pmid:16142584 |