26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.
To understand associated biological information of 26-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
26-Hydroxycholesterol is suspected in hypercholesterolemia, Obesity, Atherosclerosis, Metabolic syndrome, Neurodegenerative Disorders, Dyslipidemias and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 26-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cholesterol and breast cancer pathophysiology.' (Nelson ER et al., 2014) and Transgenic Model are used in the study 'Obesity, cholesterol metabolism, and breast cancer pathogenesis.' (McDonnell DP et al., 2014).
Knock-out are used in the study 'The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.' (Umetani M et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Umetani M et al. | The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha. | 2014 | Cell Metab. | pmid:24954418 |
| Chen W et al. | Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. | 2007 | Cell Metab. | pmid:17189208 |
| Wu Q et al. | 27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth. | 2013 | Cell Rep | pmid:24210818 |
| Huwait EA et al. | A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression. | 2011 | Cell. Signal. | pmid:21070853 |
| Marwarha G et al. | Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol. | 2012 | Cell. Signal. | pmid:21983012 |
| Leoni V and Caccia C | Oxysterols as biomarkers in neurodegenerative diseases. | 2011 | Chem. Phys. Lipids | pmid:21515244 |
| Marwarha G et al. | 27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer. | 2017 | Chem. Phys. Lipids | pmid:28583434 |
| Kikuchi T et al. | Increase of 27-hydroxycholesterol in the airways of patients with COPD: possible role of 27-hydroxycholesterol in tissue fibrosis. | 2012 | Chest | pmid:22281802 |
| Coomes E et al. | Methotrexate in atherogenesis and cholesterol metabolism. | 2011 | Cholesterol | pmid:21490773 |
| Blom T et al. | FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. | 2010 | Circ. Res. | pmid:20056921 |
| Rossouw JE et al. | Relationships of coronary heart disease with 27-hydroxycholesterol, low-density lipoprotein cholesterol, and menopausal hormone therapy. | 2012 | Circulation | pmid:22932256 |
| McDonnell DP et al. | The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer. | 2014 | Climacteric | pmid:25320023 |
| Nunes VS et al. | Plasma 27-hydroxycholesterol/cholesterol ratio is increased in low high density lipoprotein-cholesterol healthy subjects. | 2013 | Clin. Biochem. | pmid:23850851 |
| Matysik S et al. | Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors. | 2012 | Clin. Chem. | pmid:22997279 |
| Leoni V et al. | Diagnostic use of cerebral and extracerebral oxysterols. | 2004 | Clin. Chem. Lab. Med. | pmid:15061359 |
| Nunes VS et al. | Increased 27-hydroxycholesterol plasma level in men with low high density lipoprotein-cholesterol may circumvent their reduced cell cholesterol efflux rate. | 2014 | Clin. Chim. Acta | pmid:24657483 |
| Kimura A et al. | Neonatal cholestasis with increased 3β-monohydroxy-Δⵠbile acids in serum and urine: not necessarily primary oxysterol 7α hydroxylase deficiency. | 2012 | Clin. Chim. Acta | pmid:22652365 |
| Crosignani A et al. | Plasma oxysterols in normal and cholestatic children as indicators of the two pathways of bile acid synthesis. | 2008 | Clin. Chim. Acta | pmid:18538136 |
| Del Puppo M et al. | A minimally invasive technique for the evaluation of the regulatory steps of the two major pathways of bile acid synthesis. | 2005 | Clin. Chim. Acta | pmid:15820474 |
| Crosignani A et al. | Changes in classic and alternative pathways of bile acid synthesis in chronic liver disease. | 2007 | Clin. Chim. Acta | pmid:17482152 |
| Crosignani A et al. | Oxysterols in bile acid metabolism. | 2011 | Clin. Chim. Acta | pmid:21855537 |
| Sniderman AD et al. | Regulation of plasma LDL: the apoB paradigm. | 2010 | Clin. Sci. | pmid:19922416 |
| Tansley G et al. | Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. | 2012 | Curr Gerontol Geriatr Res | pmid:22649448 |
| Dasari B et al. | Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells. | 2013 | Curr. Eye Res. | pmid:23841471 |
| Jeitner TM et al. | Oxysterol derivatives of cholesterol in neurodegenerative disorders. | 2011 | Curr. Med. Chem. | pmid:21428891 |
| Seet RC et al. | Markers of oxidative damage are not elevated in otherwise healthy individuals with the metabolic syndrome. | 2010 | Diabetes Care | pmid:20185735 |
| Pikuleva IA | Cholesterol-metabolizing cytochromes P450. | 2006 | Drug Metab. Dispos. | pmid:16434543 |
| Szatmari I and Nagy L | Nuclear receptor signalling in dendritic cells connects lipids, the genome and immune function. | 2008 | EMBO J. | pmid:18716631 |
| Kimbung S et al. | Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer. | 2017 | Endocr. Relat. Cancer | pmid:28442559 |
| Rennert H et al. | Generation of regulatory oxysterols: 26-hydroxylation of cholesterol by ovarian mitochondria. | 1990 | Endocrinology | pmid:2373053 |
| DuSell CD et al. | The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. | 2010 | Endocrinology | pmid:20501668 |
| Nelson ER et al. | The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. | 2011 | Endocrinology | pmid:21933863 |
| Christenson LK et al. | Conditional response of the human steroidogenic acute regulatory protein gene promoter to sterol regulatory element binding protein-1a. | 2001 | Endocrinology | pmid:11145563 |
| Shen Z et al. | 27-Hydroxycholesterol induces invasion and migration of breast cancer cells by increasing MMP9 and generating EMT through activation of STAT-3. | 2017 | Environ. Toxicol. Pharmacol. | pmid:28257824 |
| Zhang J et al. | 7alpha-Hydroxylation and 3-dehydrogenation abolish the ability of 25-hydroxycholesterol and 27-hydroxycholesterol to induce apoptosis in thymocytes. | 1997 | Eur. J. Biochem. | pmid:9249018 |
| Rosklint T et al. | Oxysterols induce interleukin-1beta production in human macrophages. | 2002 | Eur. J. Clin. Invest. | pmid:11851725 |
| Thelen KM et al. | Effect of pravastatin on plasma sterols and oxysterols in men. | 2006 | Eur. J. Clin. Pharmacol. | pmid:16385401 |
| Tsankova V et al. | Peripheral benzodiazepine receptor ligands in rat liver mitochondria: effect on 27-hydroxylation of cholesterol. | 1996 | Eur. J. Pharmacol. | pmid:8901023 |
| Marwarha G and Ghribi O | Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap? | 2015 | Exp. Gerontol. | pmid:25261765 |
| Javitt NB | Bile acid synthesis from cholesterol: regulatory and auxiliary pathways. | 1994 | FASEB J. | pmid:8001744 |
| Meaney S | Is C-26 hydroxylation an evolutionarily conserved steroid inactivation mechanism? | 2005 | FASEB J. | pmid:16051688 |
| Toll A et al. | 7 alpha-hydroxylation of 26-hydroxycholesterol, 3 beta-hydroxy-5-cholestenoic acid and 3 beta-hydroxy-5-cholenoic acid by cytochrome P-450 in pig liver microsomes. | 1992 | FEBS Lett. | pmid:1730295 |
| Bellosta S et al. | 27-Hydroxycholesterol modulation of low density lipoprotein metabolism in cultured human hepatic and extrahepatic cells. | 1993 | FEBS Lett. | pmid:8405424 |
| Lorenzo JL et al. | Regulation of low density lipoprotein metabolism by 26-hydroxycholesterol in human fibroblasts. | 1987 | FEBS Lett. | pmid:3595864 |
| Vurusaner B et al. | Nrf2 antioxidant defense is involved in survival signaling elicited by 27-hydroxycholesterol in human promonocytic cells. | 2016 | Free Radic. Biol. Med. | pmid:26689473 |
| Vurusaner B et al. | Survival signaling elicited by 27-hydroxycholesterol through the combined modulation of cellular redox state and ERK/Akt phosphorylation. | 2014 | Free Radic. Biol. Med. | pmid:25110320 |
| Dias IH et al. | Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation. | 2014 | Free Radic. Biol. Med. | pmid:25048970 |
| Seet RC et al. | Oxidative damage in Parkinson disease: Measurement using accurate biomarkers. | 2010 | Free Radic. Biol. Med. | pmid:19969070 |
| Larsson DA et al. | Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects. | 2006 | Free Radic. Biol. Med. | pmid:16934673 |
| Seet RC et al. | Oxidative damage in dengue fever. | 2009 | Free Radic. Biol. Med. | pmid:19427377 |