26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.
To understand associated biological information of 26-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
26-Hydroxycholesterol is suspected in hypercholesterolemia, Obesity, Atherosclerosis, Metabolic syndrome, Neurodegenerative Disorders, Dyslipidemias and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 26-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cholesterol and breast cancer pathophysiology.' (Nelson ER et al., 2014) and Transgenic Model are used in the study 'Obesity, cholesterol metabolism, and breast cancer pathogenesis.' (McDonnell DP et al., 2014).
Knock-out are used in the study 'The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.' (Umetani M et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Escher G et al. | Role of CYP27A1 in progesterone metabolism in vitro and in vivo. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19671838 |
| Li T and Chiang JY | Regulation of bile acid and cholesterol metabolism by PPARs. | 2009 | PPAR Res | pmid:19636418 |
| Mateos L et al. | Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro. | 2009 | Brain Pathol. | pmid:18503570 |
| Lütjohann D et al. | 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man. | 2009 | Int J Clin Pharmacol Ther | pmid:19954708 |
| Wang Y et al. | Targeted lipidomic analysis of oxysterols in the embryonic central nervous system. | 2009 | Mol Biosyst | pmid:19381367 |
| Zhou C et al. | The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. | 2009 | Nucl Recept Signal | pmid:19240808 |
| Prasanthi JR et al. | Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. | 2009 | Mol Neurodegener | pmid:19126211 |
| Koschack J et al. | Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals. | 2009 | Neurobiol. Aging | pmid:18061309 |
| Mathieu JM et al. | Medical bioremediation of age-related diseases. | 2009 | Microb. Cell Fact. | pmid:19358742 |
| Lange Y et al. | Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol. | 2009 | J. Lipid Res. | pmid:19401598 |
| van den Kommer TN et al. | Total cholesterol and oxysterols: early markers for cognitive decline in elderly? | 2009 | Neurobiol. Aging | pmid:17888546 |
| Honda A et al. | Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. | 2009 | J. Lipid Res. | pmid:18815436 |
| Kölsch H et al. | Alterations of cholesterol precursor levels in Alzheimer's disease. | 2010 | Biochim. Biophys. Acta | pmid:20226877 |
| Blom T et al. | FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. | 2010 | Circ. Res. | pmid:20056921 |
| Wang YM et al. | The mechanism of dietary cholesterol effects on lipids metabolism in rats. | 2010 | Lipids Health Dis | pmid:20070910 |
| Dasari B et al. | The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. | 2010 | BMC Ophthalmol | pmid:20836858 |
| Berrodin TJ et al. | Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity. | 2010 | Mol. Pharmacol. | pmid:20837678 |
| Kumari U and Heese K | Cardiovascular dementia - a different perspective. | 2010 | Open Biochem J | pmid:20448820 |
| Crow JA et al. | Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. | 2010 | Biochim. Biophys. Acta | pmid:19761868 |
| DuSell CD et al. | The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. | 2010 | Endocrinology | pmid:20501668 |
| Ullrich C et al. | Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits. | 2010 | Mol. Cell. Neurosci. | pmid:20696249 |
| Marwarha G et al. | Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. | 2010 | J. Alzheimers Dis. | pmid:20157255 |
| Sniderman AD et al. | Regulation of plasma LDL: the apoB paradigm. | 2010 | Clin. Sci. | pmid:19922416 |
| Jenner AM et al. | The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. | 2010 | Neuroscience | pmid:20416362 |
| Taylor JM et al. | Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI. | 2010 | Cardiovasc. Res. | pmid:20083572 |
| Weingärtner O et al. | An alternative pathway of reverse cholesterol transport: the oxysterol 27-hydroxycholesterol. | 2010 | Atherosclerosis | pmid:19801147 |
| Seet RC et al. | Oxidative damage in Parkinson disease: Measurement using accurate biomarkers. | 2010 | Free Radic. Biol. Med. | pmid:19969070 |
| Schüle R et al. | Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. | 2010 | J. Lipid Res. | pmid:19812052 |
| Crisafulli C et al. | Effects of Liver x receptor agonist treatment on signal transduction pathways in acute lung inflammation. | 2010 | Respir. Res. | pmid:20175894 |
| Greenhill C | Bone: High 27-hydroxycholesterol decreases BMD. | 2010 | Nat Rev Endocrinol | pmid:20803803 |
| Schneider H et al. | A novel mutation in the sterol 27-hydroxylase gene of a woman with autosomal recessive cerebrotendinous xanthomatosis. | 2010 | Orphanet J Rare Dis | pmid:20925952 |
| Akram A et al. | Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis? | 2010 | Mol Neurodegener | pmid:20843353 |
| Seet RC et al. | Markers of oxidative damage are not elevated in otherwise healthy individuals with the metabolic syndrome. | 2010 | Diabetes Care | pmid:20185735 |
| Grinberg LT and Thal DR | Vascular pathology in the aged human brain. | 2010 | Acta Neuropathol. | pmid:20155424 |
| Vallim T and Salter AM | Regulation of hepatic gene expression by saturated fatty acids. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20227267 |
| Bełtowski J and Semczuk A | Liver X receptor (LXR) and the reproductive system--a potential novel target for therapeutic intervention. | 2010 Jan-Feb | Pharmacol Rep | pmid:20360612 |
| Ebrahimi KB and Handa JT | Lipids, lipoproteins, and age-related macular degeneration. | 2011 | J Lipids | pmid:21822496 |
| Honda A et al. | Cholesterol 25-hydroxylation activity of CYP3A. | 2011 | J. Lipid Res. | pmid:21576599 |
| Vejux A et al. | Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments. | 2011 | J Ophthalmol | pmid:21577274 |
| Mateos L et al. | Side chain-oxidized oxysterols regulate the brain renin-angiotensin system through a liver X receptor-dependent mechanism. | 2011 | J. Biol. Chem. | pmid:21628469 |
| Coomes E et al. | Methotrexate in atherogenesis and cholesterol metabolism. | 2011 | Cholesterol | pmid:21490773 |
| Zhang JH et al. | The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. | 2011 | J. Biol. Chem. | pmid:21602275 |
| Dasari B et al. | Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina. | 2011 | BMC Ophthalmol | pmid:21851605 |
| RamÃrez C et al. | ApoB100/LDLR-/- hypercholesterolaemic mice as a model for mild cognitive impairment and neuronal damage. | 2011 | PLoS ONE | pmid:21829488 |
| Pachikian BD et al. | Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets. | 2011 | PLoS ONE | pmid:21853118 |
| Makoukji J et al. | Interplay between LXR and Wnt/β-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols. | 2011 | J. Neurosci. | pmid:21715627 |
| Salomone S and Waeber C | Selectivity and specificity of sphingosine-1-phosphate receptor ligands: caveats and critical thinking in characterizing receptor-mediated effects. | 2011 | Front Pharmacol | pmid:21687504 |
| Marwarha G et al. | Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus. | 2011 | Mol Neurodegener | pmid:21651786 |
| Bigalke B et al. | Adipocytokines and CD34 progenitor cells in Alzheimer's disease. | 2011 | PLoS ONE | pmid:21633502 |
| Bowden KL et al. | Lysosomal acid lipase deficiency impairs regulation of ABCA1 gene and formation of high density lipoproteins in cholesteryl ester storage disease. | 2011 | J. Biol. Chem. | pmid:21757691 |