26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.
To understand associated biological information of 26-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
26-Hydroxycholesterol is suspected in hypercholesterolemia, Obesity, Atherosclerosis, Metabolic syndrome, Neurodegenerative Disorders, Dyslipidemias and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 26-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cholesterol and breast cancer pathophysiology.' (Nelson ER et al., 2014) and Transgenic Model are used in the study 'Obesity, cholesterol metabolism, and breast cancer pathogenesis.' (McDonnell DP et al., 2014).
Knock-out are used in the study 'The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.' (Umetani M et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Iborra RT et al. | Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. | 2011 | Lipids Health Dis | pmid:21957962 |
| Jeitner TM et al. | Oxysterol derivatives of cholesterol in neurodegenerative disorders. | 2011 | Curr. Med. Chem. | pmid:21428891 |
| Umetani M and Shaul PW | 27-Hydroxycholesterol: the first identified endogenous SERM. | 2011 | Trends Endocrinol. Metab. | pmid:21353593 |
| Ebrahimi KB and Handa JT | Lipids, lipoproteins, and age-related macular degeneration. | 2011 | J Lipids | pmid:21822496 |
| Honda A et al. | Cholesterol 25-hydroxylation activity of CYP3A. | 2011 | J. Lipid Res. | pmid:21576599 |
| Vejux A et al. | Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments. | 2011 | J Ophthalmol | pmid:21577274 |
| Marwarha G et al. | The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease. | 2011 | J. Neurochem. | pmid:21951066 |
| Mateos L et al. | Side chain-oxidized oxysterols regulate the brain renin-angiotensin system through a liver X receptor-dependent mechanism. | 2011 | J. Biol. Chem. | pmid:21628469 |
| Shafaati M et al. | Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation. | 2011 | J. Lipid Res. | pmid:21335619 |
| Cheng D et al. | Lipid pathway alterations in Parkinson's disease primary visual cortex. | 2011 | PLoS ONE | pmid:21387008 |
| Jusakul A et al. | Mechanisms of oxysterol-induced carcinogenesis. | 2011 | Lipids Health Dis | pmid:21388551 |
| Coomes E et al. | Methotrexate in atherogenesis and cholesterol metabolism. | 2011 | Cholesterol | pmid:21490773 |
| Zhang JH et al. | The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. | 2011 | J. Biol. Chem. | pmid:21602275 |
| Nelson ER et al. | The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. | 2011 | Endocrinology | pmid:21933863 |
| Leoni V and Caccia C | Oxysterols as biomarkers in neurodegenerative diseases. | 2011 | Chem. Phys. Lipids | pmid:21515244 |
| Dasari B et al. | Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina. | 2011 | BMC Ophthalmol | pmid:21851605 |
| RamÃrez C et al. | ApoB100/LDLR-/- hypercholesterolaemic mice as a model for mild cognitive impairment and neuronal damage. | 2011 | PLoS ONE | pmid:21829488 |
| Pachikian BD et al. | Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets. | 2011 | PLoS ONE | pmid:21853118 |
| Crosignani A et al. | Oxysterols in bile acid metabolism. | 2011 | Clin. Chim. Acta | pmid:21855537 |
| Makoukji J et al. | Interplay between LXR and Wnt/β-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols. | 2011 | J. Neurosci. | pmid:21715627 |
| Salomone S and Waeber C | Selectivity and specificity of sphingosine-1-phosphate receptor ligands: caveats and critical thinking in characterizing receptor-mediated effects. | 2011 | Front Pharmacol | pmid:21687504 |
| Marwarha G et al. | Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus. | 2011 | Mol Neurodegener | pmid:21651786 |
| Bigalke B et al. | Adipocytokines and CD34 progenitor cells in Alzheimer's disease. | 2011 | PLoS ONE | pmid:21633502 |
| Bowden KL et al. | Lysosomal acid lipase deficiency impairs regulation of ABCA1 gene and formation of high density lipoproteins in cholesteryl ester storage disease. | 2011 | J. Biol. Chem. | pmid:21757691 |
| Desmarchelier C et al. | C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia. | 2012 | BMC Genomics | pmid:22394543 |
| Lange Y et al. | Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells. | 2012 | PLoS ONE | pmid:22276143 |
| López-Velázquez JA et al. | Nuclear receptors in nonalcoholic Fatty liver disease. | 2012 | J Lipids | pmid:22187655 |
| Marwarha G et al. | Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol. | 2012 | Cell. Signal. | pmid:21983012 |
| Kikuchi T et al. | Increase of 27-hydroxycholesterol in the airways of patients with COPD: possible role of 27-hydroxycholesterol in tissue fibrosis. | 2012 | Chest | pmid:22281802 |
| Rossouw JE et al. | Relationships of coronary heart disease with 27-hydroxycholesterol, low-density lipoprotein cholesterol, and menopausal hormone therapy. | 2012 | Circulation | pmid:22932256 |
| Baker ME et al. | 3D models of human ERα and ERβ complexed with 5-androsten-3β,17β-diol. | 2012 | Steroids | pmid:22921477 |
| Kimura A et al. | Neonatal cholestasis with increased 3β-monohydroxy-Δⵠbile acids in serum and urine: not necessarily primary oxysterol 7α hydroxylase deficiency. | 2012 | Clin. Chim. Acta | pmid:22652365 |
| Fakheri RJ and Javitt NB | 27-Hydroxycholesterol, does it exist? On the nomenclature and stereochemistry of 26-hydroxylated sterols. | 2012 | Steroids | pmid:22366074 |
| Cruz P et al. | 27-hydroxycholesterol and the expression of three estrogen-sensitive proteins in MCF7 cells. | 2012 | Oncol. Rep. | pmid:22710948 |
| McDonald JG et al. | A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. | 2012 | J. Lipid Res. | pmid:22517925 |
| Cohen E et al. | Increased Levels of Human Carotid Lesion Linoleic Acid Hydroperoxide in Symptomatic and Asymptomatic Patients Is Inversely Correlated with Serum HDL and Paraoxonase 1 Activity. | 2012 | J Lipids | pmid:22690338 |
| Shentu TP et al. | The role of oxysterols in control of endothelial stiffness. | 2012 | J. Lipid Res. | pmid:22496390 |
| Bogan RL et al. | Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. | 2012 | Biol. Reprod. | pmid:22156476 |
| Zhang X et al. | Cholesterol metabolite, 5-cholesten-3β-25-diol-3-sulfate, promotes hepatic proliferation in mice. | 2012 | J. Steroid Biochem. Mol. Biol. | pmid:22732306 |
| Popp J et al. | Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease. | 2012 | J. Neurochem. | pmid:22845771 |
| Mateos L et al. | side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons. | 2012 | Neurodegener Dis | pmid:22236548 |
| Hughes TM et al. | Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's disease. | 2012 | J. Alzheimers Dis. | pmid:22377780 |
| Emanuelsson I and Norlin M | Protective effects of 27- and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells. | 2012 | Neurosci. Lett. | pmid:22884615 |
| Matysik S et al. | Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors. | 2012 | Clin. Chem. | pmid:22997279 |
| Ferreiro E et al. | Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers. | 2012 | Int J Cell Biol | pmid:22701485 |
| Schreurs BG et al. | Dietary Cholesterol Concentration and Duration Degrade Long-Term Memory of Classical Conditioning of the Rabbit's Nictitating Membrane Response. | 2012 | Int J Alzheimers Dis | pmid:22567532 |
| Milagre I et al. | Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells. | 2012 | Neurochem. Int. | pmid:22185844 |
| Li T and Chiang JY | Bile Acid signaling in liver metabolism and diseases. | 2012 | J Lipids | pmid:21991404 |
| Poirier J et al. | High-dose supplemental selenite to male Syrian hamsters fed hypercholesterolaemic diets alters Ldlr, Abcg8 and Npc1l1 mRNA expression and lowers plasma cholesterol concentrations. | 2012 | Br. J. Nutr. | pmid:22152646 |
| Brauner R et al. | Phytosterols reduce cholesterol absorption by inhibition of 27-hydroxycholesterol generation, liver X receptor α activation, and expression of the basolateral sterol exporter ATP-binding cassette A1 in Caco-2 enterocytes. | 2012 | J. Nutr. | pmid:22535758 |