26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.
To understand associated biological information of 26-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
26-Hydroxycholesterol is suspected in hypercholesterolemia, Obesity, Atherosclerosis, Metabolic syndrome, Neurodegenerative Disorders, Dyslipidemias and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 26-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Transgenic Model are used in the study 'Cholesterol and breast cancer pathophysiology.' (Nelson ER et al., 2014) and Transgenic Model are used in the study 'Obesity, cholesterol metabolism, and breast cancer pathogenesis.' (McDonnell DP et al., 2014).
Knock-out are used in the study 'The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.' (Umetani M et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xiu R et al. | [Elimination of cholesterol in human endothelial cells]. | 1997 | Zhonghua Yi Xue Za Zhi | pmid:9772537 |
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| DuSell CD and McDonnell DP | 27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling. | 2008 | Trends Pharmacol. Sci. | pmid:18722677 |
| Nelson ER et al. | Cholesterol and breast cancer pathophysiology. | 2014 | Trends Endocrinol. Metab. | pmid:25458418 |
| Umetani M and Shaul PW | 27-Hydroxycholesterol: the first identified endogenous SERM. | 2011 | Trends Endocrinol. Metab. | pmid:21353593 |
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| Liu J et al. | The ROS-mediated activation of IL-6/STAT3 signaling pathway is involved in the 27-hydroxycholesterol-induced cellular senescence in nerve cells. | 2017 | Toxicol In Vitro | pmid:28739487 |
| Guan JZ et al. | Clofibrate, a peroxisome-proliferator, enhances reverse cholesterol transport through cytochrome P450 activation and oxysterol generation. | 2003 | Tohoku J. Exp. Med. | pmid:14690017 |
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| Kaiser J | Cancer. Cholesterol forges link between obesity and breast cancer. | 2013 | Science | pmid:24288308 |
| Nelson ER et al. | 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. | 2013 | Science | pmid:24288332 |
| Civra A et al. | Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol. | 2014 | Sci Rep | pmid:25501851 |
| Babiker A et al. | Patients with atherosclerosis may have increased circulating levels of 27-hydroxycholesterol and cholestenoic acid. | 2005 | Scand. J. Clin. Lab. Invest. | pmid:16081359 |
| Luomala M et al. | Plasma-soluble CD40 is related to cholesterol metabolism in patients with moderate hypercholesterolemia. | 2006 | Scand. Cardiovasc. J. | pmid:17012138 |
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| Cagno V et al. | Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol. | 2017 | Redox Biol | pmid:28359048 |
| Jiang X et al. | Characterization of oxysterols by electrospray ionization tandem mass spectrometry after one-step derivatization with dimethylglycine. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17154356 |
| Vallim T and Salter AM | Regulation of hepatic gene expression by saturated fatty acids. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20227267 |
| Lala DS et al. | Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9144161 |
| Li T and Chiang JY | Regulation of bile acid and cholesterol metabolism by PPARs. | 2009 | PPAR Res | pmid:19636418 |
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| Prasanthi JR et al. | Silencing GADD153/CHOP gene expression protects against Alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus. | 2011 | PLoS ONE | pmid:22046282 |
| Testa G et al. | Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols. | 2014 | PLoS ONE | pmid:24802026 |
| Lappano R et al. | The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes. | 2011 | PLoS ONE | pmid:21304949 |
| Zheng W et al. | Spatial distribution of the pathways of cholesterol homeostasis in human retina. | 2012 | PLoS ONE | pmid:22629470 |
| Trousson A et al. | Cross-talk between oxysterols and glucocorticoids: differential regulation of secreted phopholipase A2 and impact on oligodendrocyte death. | 2009 | PLoS ONE | pmid:19956653 |
| Marwarha G et al. | Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells. | 2013 | PLoS ONE | pmid:23951005 |
| Cheng D et al. | Lipid pathway alterations in Parkinson's disease primary visual cortex. | 2011 | PLoS ONE | pmid:21387008 |
| Acimovic J et al. | Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice. | 2013 | PLoS ONE | pmid:23844150 |
| RamÃrez C et al. | ApoB100/LDLR-/- hypercholesterolaemic mice as a model for mild cognitive impairment and neuronal damage. | 2011 | PLoS ONE | pmid:21829488 |
| Pachikian BD et al. | Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets. | 2011 | PLoS ONE | pmid:21853118 |
| Bigalke B et al. | Adipocytokines and CD34 progenitor cells in Alzheimer's disease. | 2011 | PLoS ONE | pmid:21633502 |
| Kim BY et al. | Dexamethasone inhibits activation of monocytes/macrophages in a milieu rich in 27-oxygenated cholesterol. | 2017 | PLoS ONE | pmid:29236764 |
| Matyash V et al. | Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16. | 2004 | PLoS Biol. | pmid:15383841 |
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| Schneider H et al. | A novel mutation in the sterol 27-hydroxylase gene of a woman with autosomal recessive cerebrotendinous xanthomatosis. | 2010 | Orphanet J Rare Dis | pmid:20925952 |
| Gong H and Williams JR | Synthesis of the aglycone of the shark repellent pavoninin-4 using remote functionalization. | 2006 | Org. Lett. | pmid:16706499 |
| Kumari U and Heese K | Cardiovascular dementia - a different perspective. | 2010 | Open Biochem J | pmid:20448820 |
| Torres CG et al. | 27-hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype. | 2011 | Oncol. Rep. | pmid:21567091 |
| Cruz P et al. | 27-hydroxycholesterol and the expression of three estrogen-sensitive proteins in MCF7 cells. | 2012 | Oncol. Rep. | pmid:22710948 |
| Bertolotti M et al. | Increased appearance rate of 27-hydroxycholesterol in vivo in hypercholesterolemia: a possible compensatory mechanism. | 2012 | Nutr Metab Cardiovasc Dis | pmid:21546230 |
| Zhou C et al. | The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. | 2009 | Nucl Recept Signal | pmid:19240808 |
| An Y et al. | 27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells. | 2017 | Neurotoxicology | pmid:28167099 |
| Zhang DD et al. | 27-Hydroxycholesterol contributes to disruptive effects on learning and memory by modulating cholesterol metabolism in the rat brain. | 2015 | Neuroscience | pmid:25987203 |
| Gilardi F et al. | Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling. | 2009 | Neuroscience | pmid:19665519 |
| Jenner AM et al. | The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. | 2010 | Neuroscience | pmid:20416362 |
| Holdenrieder S et al. | Does brain specific 24S-hydroxycholesterol in plasma indicate the disruption of the blood-brain barrier in patients with ischemic stroke? | 2004 | Neurosci. Lett. | pmid:15351449 |
| Kölsch H et al. | Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients. | 2004 | Neurosci. Lett. | pmid:15364416 |
| Solomon A et al. | Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease. | 2009 | Neurosci. Lett. | pmid:19560513 |
| Emanuelsson I and Norlin M | Protective effects of 27- and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells. | 2012 | Neurosci. Lett. | pmid:22884615 |
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| Björkhem I et al. | Oxysterols and Parkinson's disease: evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease. | 2013 | Neurosci. Lett. | pmid:24035896 |
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| Cheng D et al. | Regulation of alpha-synuclein expression by liver X receptor ligands in vitro. | 2008 | Neuroreport | pmid:18841091 |
| Mateos L et al. | side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons. | 2012 | Neurodegener Dis | pmid:22236548 |
| Ma WW et al. | The oxysterol 27-hydroxycholesterol increases oxidative stress and regulate Nrf2 signaling pathway in astrocyte cells. | 2015 | Neurochem. Res. | pmid:25630716 |
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| van den Kommer TN et al. | Total cholesterol and oxysterols: early markers for cognitive decline in elderly? | 2009 | Neurobiol. Aging | pmid:17888546 |
| Umetani M et al. | 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. | 2007 | Nat. Med. | pmid:17873880 |
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