26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.
To understand associated biological information of 26-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
26-Hydroxycholesterol is suspected in hypercholesterolemia, Obesity, Atherosclerosis, Metabolic syndrome, Neurodegenerative Disorders, Dyslipidemias and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 26-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cholesterol and breast cancer pathophysiology.' (Nelson ER et al., 2014) and Transgenic Model are used in the study 'Obesity, cholesterol metabolism, and breast cancer pathogenesis.' (McDonnell DP et al., 2014).
Knock-out are used in the study 'The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.' (Umetani M et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Luomala M et al. | Osteopontin levels are associated with cholesterol synthesis markers in mildly hypercholesterolaemic patients. | 2007 | Acta Cardiol | pmid:17536607 |
| Björkhem I et al. | Oxysterols and Alzheimer's disease. | 2006 | Acta Neurol. Scand., Suppl.c | pmid:16866910 |
| Grinberg LT and Thal DR | Vascular pathology in the aged human brain. | 2010 | Acta Neuropathol. | pmid:20155424 |
| Lütjohann D et al. | Cholesterol dynamics in the foetal and neonatal brain as reflected by circulatory levels of 24S-hydroxycholesterol. | 2001 | Acta Paediatr. | pmid:11440099 |
| Gamba P et al. | Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. | 2011 | Aging Cell | pmid:21272192 |
| Gargiulo S et al. | Relation between TLR4/NF-κB signaling pathway activation by 27-hydroxycholesterol and 4-hydroxynonenal, and atherosclerotic plaque instability. | 2015 | Aging Cell | pmid:25757594 |
| Gamba P et al. | Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine. | 2014 | Aging Cell | pmid:24612036 |
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| Upston JM et al. | Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis. | 2002 | Am. J. Pathol. | pmid:11839591 |
| Escher G et al. | Role of CYP27A1 in progesterone metabolism in vitro and in vivo. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19671838 |
| de Vogel-van den Bosch HM et al. | A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18356535 |
| Hall E et al. | Overexpression of CYP27 in hepatic and extrahepatic cells: role in the regulation of cholesterol homeostasis. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11408283 |
| Hashimoto Y et al. | 27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27036870 |
| Yoshida T et al. | Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry. | 2008 | Anal Chem Insights | pmid:19609389 |
| Wu Y et al. | Liver X receptor as a drug target for the treatment of breast cancer. | 2016 | Anticancer Drugs | pmid:26872310 |
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| Guéguen Y et al. | Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat. | 2006 | Arch. Toxicol. | pmid:16231126 |
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| Westman J et al. | Sterol 27-hydroxylase- and apoAI/phospholipid-mediated efflux of cholesterol from cholesterol-laden macrophages: evidence for an inverse relation between the two mechanisms. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9555860 |
| Corsini A et al. | Effects of 26-aminocholesterol, 27-hydroxycholesterol, and 25-hydroxycholesterol on proliferation and cholesterol homeostasis in arterial myocytes. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7749852 |
| Kushwaha RS et al. | Effect of dietary cholesterol and fat on the expression of hepatic sterol 27-hydroxylase and other hepatic cholesterol-responsive genes in baboons (Papio species). | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7670955 |
| von Bahr S et al. | Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1). | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:12117727 |
| Karuna R et al. | Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism. | 2011 | Atherosclerosis | pmid:21130455 |
| Yasunobu Y et al. | Coronary atherosclerosis and oxidative stress as reflected by autoantibodies against oxidized low-density lipoprotein and oxysterols. | 2001 | Atherosclerosis | pmid:11254916 |
| Weingärtner O et al. | An alternative pathway of reverse cholesterol transport: the oxysterol 27-hydroxycholesterol. | 2010 | Atherosclerosis | pmid:19801147 |
| Burkard I et al. | Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers. | 2007 | Atherosclerosis | pmid:17107679 |
| Chen LD et al. | Effect of naturally reduced ovarian function on plasma lipoprotein and 27-hydroxycholesterol levels in baboons (Papio sp.). | 1998 | Atherosclerosis | pmid:9544735 |
| Morello F et al. | LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. | 2009 | Atherosclerosis | pmid:19426978 |
| Shanahan CM et al. | A potential role for sterol 27-hydroxylase in atherogenesis. | 2001 | Atherosclerosis | pmid:11166758 |
| Gueguen Y et al. | Compared effect of immunosuppressive drugs cyclosporine A and rapamycin on cholesterol homeostasis key enzymes CYP27A1 and HMG-CoA reductase. | 2007 | Basic Clin. Pharmacol. Toxicol. | pmid:17516993 |
| Heverin M et al. | 27-hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice. | 2015 | Behav. Brain Res. | pmid:25453744 |
| Kim SM et al. | 27-Oxygenated cholesterol induces expression of CXCL8 in macrophages via NF-κB and CD88. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26086093 |
| Gosselet F et al. | Effects of oxysterols on the blood-brain barrier: implications for Alzheimer's disease. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24275140 |
| Pinkerton FD et al. | Synergistic action of two oxysterols in the lowering of HMG-CoA reductase activity in CHO-K1 cells. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1632792 |
| Postlind H and Wikvall K | Evidence for the formation of 26-hydroxycholesterol by cytochrome P-450 in pig kidney mitochondria. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2930554 |
| Pinkerton FD et al. | Differing effects of three oxysterols on low density lipoprotein metabolism in HepG2 cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8391799 |
| Kim SM et al. | 27-hydroxycholesterol induces production of tumor necrosis factor-alpha from macrophages. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23246833 |
| Kim SM et al. | 27-Hydroxycholesterol induces recruitment of monocytic cells by enhancing CCL2 production. | 2013 | Biochem. Biophys. Res. Commun. | pmid:24269812 |
| Meljon A et al. | Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24491562 |
| Baila-Rueda L et al. | Bile acid synthesis precursors in familial combined hyperlipidemia: the oxysterols 24S-hydroxycholesterol and 27-hydroxycholesterol. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24406166 |
| Son Y et al. | Oxysterols induce transition of monocytic cells to phenotypically mature dendritic cell-like cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23876312 |
| Ma LM et al. | 27-Hydroxycholesterol increases Myc protein stability via suppressing PP2A, SCP1 and FBW7 transcription in MCF-7 breast cancer cells. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27751849 |
| Kim BY et al. | Diclofenac inhibits 27-hydroxycholesterol-induced inflammation. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27576203 |
| Miao E et al. | Cholesterol metabolism. Effect of 26-thiacholesterol and 26-aminocholesterol, analogues of 26-hydroxycholesterol, on cholesterol synthesis and low-density-lipoprotein-receptor binding. | 1988 | Biochem. J. | pmid:2850793 |
| Zhang J et al. | Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons. | 1997 | Biochem. J. | pmid:9078259 |
| Smith AG et al. | The isolation of cholest-5-ene-3beta,26-diol from human brain. | 1974 | Biochem. J. | pmid:4854921 |
| Javitt NB and Budai K | Cholesterol and bile acid synthesis in Hep G2 cells. Metabolic effects of 26- and 7 alpha-hydroxycholesterol. | 1989 | Biochem. J. | pmid:2556116 |
| Jimi S et al. | 26-hydroxycholesterol-stimulated DNA synthesis in smooth muscle cells and induction of endothelial injury using a coculture technique. | 1990 | Biochem. Med. Metab. Biol. | pmid:2252612 |