26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.
To understand associated biological information of 26-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
26-Hydroxycholesterol is suspected in hypercholesterolemia, Obesity, Atherosclerosis, Metabolic syndrome, Neurodegenerative Disorders, Dyslipidemias and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 26-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cholesterol and breast cancer pathophysiology.' (Nelson ER et al., 2014) and Transgenic Model are used in the study 'Obesity, cholesterol metabolism, and breast cancer pathogenesis.' (McDonnell DP et al., 2014).
Knock-out are used in the study 'The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.' (Umetani M et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Duane WC and Javitt NB | 27-hydroxycholesterol: production rates in normal human subjects. | 1999 | J. Lipid Res. | pmid:10393204 |
| Babiker A et al. | Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin. | 1999 | J. Lipid Res. | pmid:10428977 |
| Wu Z et al. | Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1. | 1999 | J. Lipid Res. | pmid:10588945 |
| Li-Hawkins J et al. | Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. | 2000 | J. Biol. Chem. | pmid:10748047 |
| Li S et al. | Kinetics and plasma concentrations of 26-hydroxycholesterol in baboons. | 2000 | Biochim. Biophys. Acta | pmid:10832098 |
| Norlin M et al. | Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A). | 2000 | J. Biol. Chem. | pmid:10882719 |
| D'Ambra TE et al. | Oxysterols: 27-hydroxycholesterol and its radiolabeled analog. | 2000 | Steroids | pmid:10899540 |
| Li D and Spencer TA | Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols. | 2000 | Steroids | pmid:10978732 |
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| Russell DW | Oxysterol biosynthetic enzymes. | 2000 | Biochim. Biophys. Acta | pmid:11111082 |
| Javitt NB | Biologic role(s) of the 25(R),26-hydroxycholesterol metabolic pathway. | 2000 | Biochim. Biophys. Acta | pmid:11111083 |
| Christenson LK et al. | Conditional response of the human steroidogenic acute regulatory protein gene promoter to sterol regulatory element binding protein-1a. | 2001 | Endocrinology | pmid:11145563 |
| Meaney S et al. | Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study. | 2001 | J. Lipid Res. | pmid:11160367 |
| Shanahan CM et al. | A potential role for sterol 27-hydroxylase in atherogenesis. | 2001 | Atherosclerosis | pmid:11166758 |
| Honda A et al. | Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27(-/-) mice and CTX. | 2001 | J. Lipid Res. | pmid:11181760 |
| Björkhem I et al. | Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol. | 2001 | J. Lipid Res. | pmid:11254748 |
| Del Puppo M et al. | Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration. | 2001 | J. Lipid Res. | pmid:11254756 |
| Yasunobu Y et al. | Coronary atherosclerosis and oxidative stress as reflected by autoantibodies against oxidized low-density lipoprotein and oxysterols. | 2001 | Atherosclerosis | pmid:11254916 |
| Zhang Z et al. | Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations. | 2001 | J. Lipid Res. | pmid:11290837 |
| Hall E et al. | Overexpression of CYP27 in hepatic and extrahepatic cells: role in the regulation of cholesterol homeostasis. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11408283 |
| Lütjohann D et al. | Cholesterol dynamics in the foetal and neonatal brain as reflected by circulatory levels of 24S-hydroxycholesterol. | 2001 | Acta Paediatr. | pmid:11440099 |
| Bertolotti M et al. | Suppression of bile acid synthesis, but not of hepatic cholesterol 7alpha-hydroxylase expression, by obstructive cholestasis in humans. | 2001 | Hepatology | pmid:11481606 |
| Fu X et al. | 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. | 2001 | J. Biol. Chem. | pmid:11504730 |
| Bodin K et al. | Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4. | 2001 | J. Biol. Chem. | pmid:11514559 |
| Reiss AB et al. | Immune complexes and IFN-gamma decrease cholesterol 27-hydroxylase in human arterial endothelium and macrophages. | 2001 | J. Lipid Res. | pmid:11714861 |
| Upston JM et al. | Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis. | 2002 | Am. J. Pathol. | pmid:11839591 |
| Rosklint T et al. | Oxysterols induce interleukin-1beta production in human macrophages. | 2002 | Eur. J. Clin. Invest. | pmid:11851725 |
| Duane WC and Javitt NB | Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis? | 2002 | J. Lab. Clin. Med. | pmid:11919549 |
| Norlin M | Expression of key enzymes in bile acid biosynthesis during development: CYP7B1-mediated activities show tissue-specific differences. | 2002 | J. Lipid Res. | pmid:11971943 |
| Pandak WM et al. | Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. | 2002 | Hepatology | pmid:12029625 |
| von Bahr S et al. | Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1). | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:12117727 |
| Meir K et al. | Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis. | 2002 | J. Biol. Chem. | pmid:12119285 |
| Oyama T et al. | Effect of deposited lipids in atheromatous lesions on the migration of vascular smooth muscle cells. | 2002 | J. Atheroscler. Thromb. | pmid:12236314 |
| Pandak WM et al. | Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes. | 2002 | J. Biol. Chem. | pmid:12368294 |
| Williams JR et al. | Synthesis of (25R)-26-hydroxycholesterol. | 2002 | Steroids | pmid:12441189 |
| Meaney S et al. | On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function. | 2002 | J. Lipid Res. | pmid:12454275 |
| Teunissen CE et al. | Serum cholesterol, precursors and metabolites and cognitive performance in an aging population. | 2003 Jan-Feb | Neurobiol. Aging | pmid:12493560 |
| Jabara S et al. | Stromal cells of the human postmenopausal ovary display a distinctive biochemical and molecular phenotype. | 2003 | J. Clin. Endocrinol. Metab. | pmid:12519894 |
| Escher G et al. | Expression of sterol 27-hydroxylase (CYP27A1) enhances cholesterol efflux. | 2003 | J. Biol. Chem. | pmid:12531903 |
| Leoni V et al. | Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers. | 2003 | J. Lipid Res. | pmid:12562838 |
| Hansson M et al. | Marked induction of sterol 27-hydroxylase activity and mRNA levels during differentiation of human cultured monocytes into macrophages. | 2003 | Biochim. Biophys. Acta | pmid:12581873 |
| Frolov A et al. | NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols. | 2003 | J. Biol. Chem. | pmid:12719428 |
| Wassif CA et al. | 27-Hydroxylation of 7- and 8-dehydrocholesterol in Smith-Lemli-Opitz syndrome: a novel metabolic pathway. | 2003 | Steroids | pmid:12906934 |
| Meaney S et al. | On the origin of the cholestenoic acids in human circulation. | 2003 | Steroids | pmid:12957664 |
| FREDRICKSON DS and ONO K | The in vitro production of 25- and 26-hydroxycholesterol and their in vivo metabolism. | 1956 | Biochim. Biophys. Acta | pmid:13373861 |
| Björkhem I et al. | 7 alpha-hydroxylation of 27-hydroxycholesterol in human liver microsomes. | 1992 | Biochim. Biophys. Acta | pmid:1390879 |
| Heverin M et al. | Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. | 2004 | J. Lipid Res. | pmid:14523054 |
| Tuomainen TP et al. | Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man. | 2003 | Free Radic. Biol. Med. | pmid:14556856 |
| Yoshida T et al. | Origin of oxysterols in hepatic bile of patients with biliary infection. | 2003 | Am. J. Gastroenterol. | pmid:14572579 |