26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.
To understand associated biological information of 26-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
26-Hydroxycholesterol is suspected in hypercholesterolemia, Obesity, Atherosclerosis, Metabolic syndrome, Neurodegenerative Disorders, Dyslipidemias and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 26-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cholesterol and breast cancer pathophysiology.' (Nelson ER et al., 2014) and Transgenic Model are used in the study 'Obesity, cholesterol metabolism, and breast cancer pathogenesis.' (McDonnell DP et al., 2014).
Knock-out are used in the study 'The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.' (Umetani M et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Marengo B et al. | Oxysterol mixture and, in particular, 27-hydroxycholesterol drive M2 polarization of human macrophages. | Biofactors | pmid:26669587 | |
| pmid: | ||||
| FREDRICKSON DS and ONO K | The in vitro production of 25- and 26-hydroxycholesterol and their in vivo metabolism. | 1956 | Biochim. Biophys. Acta | pmid:13373861 |
| Smith AG et al. | The isolation of cholest-5-ene-3beta,26-diol from human brain. | 1974 | Biochem. J. | pmid:4854921 |
| Javitt NB et al. | 26-Hydroxycholesterol. Identification and quantitation in human serum. | 1981 | J. Biol. Chem. | pmid:7309726 |
| Javitt NB et al. | Cholest-5-ene-3 beta, 26-diol: synthesis and biomedical use of a deuterated compound. | 1982 | Biomed. Mass Spectrom. | pmid:7059660 |
| Ichinose L | Possible new regulator of atherosclerosis is found. | 1982 | JAMA | pmid:7087117 |
| Goldman M et al. | Bile acid metabolism in cirrhosis. VIII. Quantitative evaluation of bile acid synthesis from [7 beta-3H]7 alpha-hydroxycholesterol and [G-3H]26-hydroxycholesterol. | 1982 Jan-Feb | Hepatology | pmid:7054068 |
| Esterman AL et al. | 26-hydroxycholesterol: regulation of hydroxymethylglutaryl-CoA reductase activity in Chinese hamster ovary cell culture. | 1983 | J. Lipid Res. | pmid:6644180 |
| Javitt NB et al. | Rapid synthesis of 26-hydroxycholesterol from mevalonic acid in the Syrian hamster. | 1984 | Biochim. Biophys. Acta | pmid:6733127 |
| Esterman AL et al. | Cholesterol metabolism: use of D2O for determination of synthesis rate in cell culture. | 1985 | J. Lipid Res. | pmid:2995527 |
| Krisans SK et al. | Bile acid synthesis in rat liver peroxisomes: metabolism of 26-hydroxycholesterol to 3 beta-hydroxy-5-cholenoic acid. | 1985 | J. Lipid Res. | pmid:4067421 |
| Lorenzo JL et al. | Regulation of low density lipoprotein metabolism by 26-hydroxycholesterol in human fibroblasts. | 1987 | FEBS Lett. | pmid:3595864 |
| Miao E et al. | Cholesterol metabolism. Effect of 26-thiacholesterol and 26-aminocholesterol, analogues of 26-hydroxycholesterol, on cholesterol synthesis and low-density-lipoprotein-receptor binding. | 1988 | Biochem. J. | pmid:2850793 |
| Ayaki Y et al. | Cholic acid synthesis from 26-hydroxycholesterol and 3-hydroxy-5-cholestenoic acid in the rabbit. | 1989 | J. Biol. Chem. | pmid:2917979 |
| Postlind H and Wikvall K | Evidence for the formation of 26-hydroxycholesterol by cytochrome P-450 in pig kidney mitochondria. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2930554 |
| Javitt NB and Budai K | Cholesterol and bile acid synthesis in Hep G2 cells. Metabolic effects of 26- and 7 alpha-hydroxycholesterol. | 1989 | Biochem. J. | pmid:2556116 |
| Jimi S et al. | 26-hydroxycholesterol-stimulated DNA synthesis in smooth muscle cells and induction of endothelial injury using a coculture technique. | 1990 | Biochem. Med. Metab. Biol. | pmid:2252612 |
| Rennert H et al. | Generation of regulatory oxysterols: 26-hydroxylation of cholesterol by ovarian mitochondria. | 1990 | Endocrinology | pmid:2373053 |
| Javitt NB | 26-Hydroxycholesterol: synthesis, metabolism, and biologic activities. | 1990 | J. Lipid Res. | pmid:2246606 |
| Kou IL et al. | Influence of 26-hydroxycholesterol on the composition and function of gel-filtered platelets. | 1991 | J Am Coll Nutr | pmid:2030252 |
| Pinkerton FD et al. | Synergistic action of two oxysterols in the lowering of HMG-CoA reductase activity in CHO-K1 cells. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1632792 |
| Toll A et al. | 7 alpha-hydroxylation of 26-hydroxycholesterol, 3 beta-hydroxy-5-cholestenoic acid and 3 beta-hydroxy-5-cholenoic acid by cytochrome P-450 in pig liver microsomes. | 1992 | FEBS Lett. | pmid:1730295 |
| Björkhem I et al. | 7 alpha-hydroxylation of 27-hydroxycholesterol in human liver microsomes. | 1992 | Biochim. Biophys. Acta | pmid:1390879 |
| Carpenter KL et al. | Lipids and oxidised lipids in human atheroma and normal aorta. | 1993 | Biochim. Biophys. Acta | pmid:8466938 |
| Martin KO et al. | Cholesterol and 27-hydroxycholesterol 7 alpha-hydroxylation: evidence for two different enzymes. | 1993 | J. Lipid Res. | pmid:8496664 |
| Petrack B and Latario BJ | Synthesis of 27-hydroxycholesterol in rat liver mitochondria: HPLC assay and marked activation by exogenous cholesterol. | 1993 | J. Lipid Res. | pmid:8496670 |
| Zhou Q and Kummerow FA | Modifying effect of 26-hydroxycholesterol on low-magnesium-induced atherosclerotic changes in the cultured human arterial smooth muscle cell. | 1993 | Magnes Res | pmid:8274357 |
| Pinkerton FD et al. | Differing effects of three oxysterols on low density lipoprotein metabolism in HepG2 cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8391799 |
| Shoda J et al. | Synthesis of potential C27-intermediates in bile acid biosynthesis and their deuterium-labeled analogs. | 1993 | Steroids | pmid:8475516 |
| Hasan SQ and Kushwaha RS | Differences in 27-hydroxycholesterol concentrations in plasma and liver of baboons with high and low responses to dietary cholesterol and fat. | 1993 | Biochim. Biophys. Acta | pmid:8399364 |
| Bellosta S et al. | 27-Hydroxycholesterol modulation of low density lipoprotein metabolism in cultured human hepatic and extrahepatic cells. | 1993 | FEBS Lett. | pmid:8405424 |
| Lund E et al. | 24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver. | 1993 | Biochim. Biophys. Acta | pmid:8443234 |
| Ni Y et al. | Inhibitors of sterol synthesis. Tritium-labeled 26-hydroxycholesterol of high specific activity from a byproduct of the Clemmensen reduction of diosgenin. | 1994 | J. Lipid Res. | pmid:8014589 |
| Reiss AB et al. | Sterol 27-hydroxylase: high levels of activity in vascular endothelium. | 1994 | J. Lipid Res. | pmid:8077842 |
| Javitt NB | Bile acid synthesis from cholesterol: regulatory and auxiliary pathways. | 1994 | FASEB J. | pmid:8001744 |
| Zhang J et al. | 7 alpha-Hydroxylation of 25-hydroxycholesterol and 27-hydroxycholesterol in human fibroblasts. | 1995 | Biochim. Biophys. Acta | pmid:7786899 |
| Szedlacsek SE et al. | Esterification of oxysterols by human plasma lecithin-cholesterol acyltransferase. | 1995 | J. Biol. Chem. | pmid:7744831 |
| Carpenter KL et al. | Lipids and oxidised lipids in human atherosclerotic lesions at different stages of development. | 1995 | Biochim. Biophys. Acta | pmid:7766691 |
| Axelson M et al. | Structural specificity in the suppression of HMG-CoA reductase in human fibroblasts by intermediates in bile acid biosynthesis. | 1995 | J. Lipid Res. | pmid:7751816 |
| Corsini A et al. | Effects of 26-aminocholesterol, 27-hydroxycholesterol, and 25-hydroxycholesterol on proliferation and cholesterol homeostasis in arterial myocytes. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7749852 |
| Axelson M and Larsson O | Low density lipoprotein (LDL) cholesterol is converted to 27-hydroxycholesterol in human fibroblasts. Evidence that 27-hydroxycholesterol can be an important intracellular mediator between LDL and the suppression of cholesterol production. | 1995 | J. Biol. Chem. | pmid:7797494 |
| Kushwaha RS et al. | Effect of dietary cholesterol and fat on the expression of hepatic sterol 27-hydroxylase and other hepatic cholesterol-responsive genes in baboons (Papio species). | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7670955 |
| Marinovich M et al. | Effect of 25-hydroxycholesterol, 26-hydroxycholesterol and its analogue, 26-aminocholesterol, on protein content, protein synthesis and LDH leakage in mouse epidermal cells. | 1995 | Toxicology | pmid:7761997 |
| Sauter G et al. | Formation of cholic acid and chenodeoxycholic acid from 7 alpha-hydroxycholesterol and 27-hydroxycholesterol by primary cultures of human hepatocytes. | 1996 | Biochim. Biophys. Acta | pmid:8608157 |
| Winegar DA et al. | Effects of cyclosporin on cholesterol 27-hydroxylation and LDL receptor activity in HepG2 cells. | 1996 | J. Lipid Res. | pmid:8820113 |
| Lee C et al. | Bile acid synthesis: 7 alpha-hydroxylation of intermediates in the sterol 27-hydroxylase metabolic pathway. | 1996 | J. Lipid Res. | pmid:8808770 |
| Tsankova V et al. | Peripheral benzodiazepine receptor ligands in rat liver mitochondria: effect on 27-hydroxylation of cholesterol. | 1996 | Eur. J. Pharmacol. | pmid:8901023 |
| Reiss AB et al. | Sterol 27-hydroxylase: expression in human arterial endothelium. | 1997 | J. Lipid Res. | pmid:9215552 |
| Crisby M et al. | Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques. | 1997 | Biochim. Biophys. Acta | pmid:9059518 |