26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.
To understand associated biological information of 26-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
26-Hydroxycholesterol is suspected in hypercholesterolemia, Obesity, Atherosclerosis, Metabolic syndrome, Neurodegenerative Disorders, Dyslipidemias and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 26-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Transgenic Model are used in the study 'Cholesterol and breast cancer pathophysiology.' (Nelson ER et al., 2014) and Transgenic Model are used in the study 'Obesity, cholesterol metabolism, and breast cancer pathogenesis.' (McDonnell DP et al., 2014).
Knock-out are used in the study 'The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.' (Umetani M et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Desmarchelier C et al. | C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia. | 2012 | BMC Genomics | pmid:22394543 |
| Tansley G et al. | Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. | 2012 | Curr Gerontol Geriatr Res | pmid:22649448 |
| Lange Y et al. | Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells. | 2012 | PLoS ONE | pmid:22276143 |
| López-Velázquez JA et al. | Nuclear receptors in nonalcoholic Fatty liver disease. | 2012 | J Lipids | pmid:22187655 |
| Marwarha G et al. | Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol. | 2012 | Cell. Signal. | pmid:21983012 |
| Kikuchi T et al. | Increase of 27-hydroxycholesterol in the airways of patients with COPD: possible role of 27-hydroxycholesterol in tissue fibrosis. | 2012 | Chest | pmid:22281802 |
| Baker ME et al. | 3D models of human ERα and ERβ complexed with 5-androsten-3β,17β-diol. | 2012 | Steroids | pmid:22921477 |
| Zheng W et al. | Spatial distribution of the pathways of cholesterol homeostasis in human retina. | 2012 | PLoS ONE | pmid:22629470 |
| Kimura A et al. | Neonatal cholestasis with increased 3β-monohydroxy-Δⵠbile acids in serum and urine: not necessarily primary oxysterol 7α hydroxylase deficiency. | 2012 | Clin. Chim. Acta | pmid:22652365 |
| Fakheri RJ and Javitt NB | 27-Hydroxycholesterol, does it exist? On the nomenclature and stereochemistry of 26-hydroxylated sterols. | 2012 | Steroids | pmid:22366074 |
| Rosales-Corral S et al. | Accumulation of exogenous amyloid-beta peptide in hippocampal mitochondria causes their dysfunction: a protective role for melatonin. | 2012 | Oxid Med Cell Longev | pmid:22666521 |
| Cruz P et al. | 27-hydroxycholesterol and the expression of three estrogen-sensitive proteins in MCF7 cells. | 2012 | Oncol. Rep. | pmid:22710948 |
| McDonald JG et al. | A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. | 2012 | J. Lipid Res. | pmid:22517925 |
| Cohen E et al. | Increased Levels of Human Carotid Lesion Linoleic Acid Hydroperoxide in Symptomatic and Asymptomatic Patients Is Inversely Correlated with Serum HDL and Paraoxonase 1 Activity. | 2012 | J Lipids | pmid:22690338 |
| Siam A et al. | Comparative modeling of 25-hydroxycholesterol-7α-hydroxylase (CYP7B1): ligand binding and analysis of hereditary spastic paraplegia type 5 CYP7B1 mutations. | 2012 | J Mol Model | pmid:21541746 |
| Shentu TP et al. | The role of oxysterols in control of endothelial stiffness. | 2012 | J. Lipid Res. | pmid:22496390 |
| Bogan RL et al. | Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. | 2012 | Biol. Reprod. | pmid:22156476 |
| Zhang X et al. | Cholesterol metabolite, 5-cholesten-3β-25-diol-3-sulfate, promotes hepatic proliferation in mice. | 2012 | J. Steroid Biochem. Mol. Biol. | pmid:22732306 |
| Mateos L et al. | side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons. | 2012 | Neurodegener Dis | pmid:22236548 |
| Hughes TM et al. | Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's disease. | 2012 | J. Alzheimers Dis. | pmid:22377780 |
| Emanuelsson I and Norlin M | Protective effects of 27- and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells. | 2012 | Neurosci. Lett. | pmid:22884615 |
| Ferreiro E et al. | Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers. | 2012 | Int J Cell Biol | pmid:22701485 |
| Bertolotti M et al. | Increased appearance rate of 27-hydroxycholesterol in vivo in hypercholesterolemia: a possible compensatory mechanism. | 2012 | Nutr Metab Cardiovasc Dis | pmid:21546230 |
| Wolf A et al. | ABC Transporters and the Alzheimer's Disease Enigma. | 2012 | Front Psychiatry | pmid:22675311 |
| Schreurs BG et al. | Dietary Cholesterol Concentration and Duration Degrade Long-Term Memory of Classical Conditioning of the Rabbit's Nictitating Membrane Response. | 2012 | Int J Alzheimers Dis | pmid:22567532 |
| Milagre I et al. | Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells. | 2012 | Neurochem. Int. | pmid:22185844 |
| Li T and Chiang JY | Bile Acid signaling in liver metabolism and diseases. | 2012 | J Lipids | pmid:21991404 |
| Poirier J et al. | High-dose supplemental selenite to male Syrian hamsters fed hypercholesterolaemic diets alters Ldlr, Abcg8 and Npc1l1 mRNA expression and lowers plasma cholesterol concentrations. | 2012 | Br. J. Nutr. | pmid:22152646 |
| Brauner R et al. | Phytosterols reduce cholesterol absorption by inhibition of 27-hydroxycholesterol generation, liver X receptor α activation, and expression of the basolateral sterol exporter ATP-binding cassette A1 in Caco-2 enterocytes. | 2012 | J. Nutr. | pmid:22535758 |
| Glöckner F et al. | Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice. | 2011 | J. Neuropathol. Exp. Neurol. | pmid:21412171 |
| Gamba P et al. | Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. | 2011 | Aging Cell | pmid:21272192 |
| Karuna R et al. | Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism. | 2011 | Atherosclerosis | pmid:21130455 |
| Iborra RT et al. | Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. | 2011 | Lipids Health Dis | pmid:21957962 |
| Mateos L et al. | Upregulation of brain renin angiotensin system by 27-hydroxycholesterol in Alzheimer's disease. | 2011 | J. Alzheimers Dis. | pmid:21297254 |
| Torres CG et al. | 27-hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype. | 2011 | Oncol. Rep. | pmid:21567091 |
| Jeitner TM et al. | Oxysterol derivatives of cholesterol in neurodegenerative disorders. | 2011 | Curr. Med. Chem. | pmid:21428891 |
| Umetani M and Shaul PW | 27-Hydroxycholesterol: the first identified endogenous SERM. | 2011 | Trends Endocrinol. Metab. | pmid:21353593 |
| Prasanthi JR et al. | Silencing GADD153/CHOP gene expression protects against Alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus. | 2011 | PLoS ONE | pmid:22046282 |
| Ebrahimi KB and Handa JT | Lipids, lipoproteins, and age-related macular degeneration. | 2011 | J Lipids | pmid:21822496 |
| Honda A et al. | Cholesterol 25-hydroxylation activity of CYP3A. | 2011 | J. Lipid Res. | pmid:21576599 |
| Vejux A et al. | Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments. | 2011 | J Ophthalmol | pmid:21577274 |
| Hong C et al. | Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. | 2011 | J. Lipid Res. | pmid:21187453 |
| Huwait EA et al. | A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression. | 2011 | Cell. Signal. | pmid:21070853 |
| Lappano R et al. | The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes. | 2011 | PLoS ONE | pmid:21304949 |
| Marwarha G et al. | The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease. | 2011 | J. Neurochem. | pmid:21951066 |
| Mateos L et al. | Side chain-oxidized oxysterols regulate the brain renin-angiotensin system through a liver X receptor-dependent mechanism. | 2011 | J. Biol. Chem. | pmid:21628469 |
| Baker ME | Insights from the structure of estrogen receptor into the evolution of estrogens: implications for endocrine disruption. | 2011 | Biochem. Pharmacol. | pmid:21420388 |
| Shafaati M et al. | Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation. | 2011 | J. Lipid Res. | pmid:21335619 |
| Seet RC et al. | Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? | 2011 | Free Radic. Biol. Med. | pmid:21420490 |
| Cheng D et al. | Lipid pathway alterations in Parkinson's disease primary visual cortex. | 2011 | PLoS ONE | pmid:21387008 |
| Jusakul A et al. | Mechanisms of oxysterol-induced carcinogenesis. | 2011 | Lipids Health Dis | pmid:21388551 |
| Coomes E et al. | Methotrexate in atherogenesis and cholesterol metabolism. | 2011 | Cholesterol | pmid:21490773 |
| Mast N et al. | Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:20881306 |
| Zhang JH et al. | The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. | 2011 | J. Biol. Chem. | pmid:21602275 |
| Nelson ER et al. | The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. | 2011 | Endocrinology | pmid:21933863 |
| Leoni V and Caccia C | Oxysterols as biomarkers in neurodegenerative diseases. | 2011 | Chem. Phys. Lipids | pmid:21515244 |
| Dasari B et al. | Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina. | 2011 | BMC Ophthalmol | pmid:21851605 |
| Liao WL et al. | Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain. | 2011 | J. Proteome Res. | pmid:21049985 |
| RamÃrez C et al. | ApoB100/LDLR-/- hypercholesterolaemic mice as a model for mild cognitive impairment and neuronal damage. | 2011 | PLoS ONE | pmid:21829488 |
| Pachikian BD et al. | Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets. | 2011 | PLoS ONE | pmid:21853118 |
| Leoni V et al. | Whole body cholesterol metabolism is impaired in Huntington's disease. | 2011 | Neurosci. Lett. | pmid:21406216 |
| Crosignani A et al. | Oxysterols in bile acid metabolism. | 2011 | Clin. Chim. Acta | pmid:21855537 |
| Makoukji J et al. | Interplay between LXR and Wnt/β-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols. | 2011 | J. Neurosci. | pmid:21715627 |
| Salomone S and Waeber C | Selectivity and specificity of sphingosine-1-phosphate receptor ligands: caveats and critical thinking in characterizing receptor-mediated effects. | 2011 | Front Pharmacol | pmid:21687504 |
| Marwarha G et al. | Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus. | 2011 | Mol Neurodegener | pmid:21651786 |
| Bigalke B et al. | Adipocytokines and CD34 progenitor cells in Alzheimer's disease. | 2011 | PLoS ONE | pmid:21633502 |
| Bowden KL et al. | Lysosomal acid lipase deficiency impairs regulation of ABCA1 gene and formation of high density lipoproteins in cholesteryl ester storage disease. | 2011 | J. Biol. Chem. | pmid:21757691 |
| Bełtowski J and Semczuk A | Liver X receptor (LXR) and the reproductive system--a potential novel target for therapeutic intervention. | 2010 Jan-Feb | Pharmacol Rep | pmid:20360612 |
| Vallim T and Salter AM | Regulation of hepatic gene expression by saturated fatty acids. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20227267 |
| Kölsch H et al. | Alterations of cholesterol precursor levels in Alzheimer's disease. | 2010 | Biochim. Biophys. Acta | pmid:20226877 |
| Blom T et al. | FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. | 2010 | Circ. Res. | pmid:20056921 |
| Wang YM et al. | The mechanism of dietary cholesterol effects on lipids metabolism in rats. | 2010 | Lipids Health Dis | pmid:20070910 |
| Dasari B et al. | The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. | 2010 | BMC Ophthalmol | pmid:20836858 |
| Berrodin TJ et al. | Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity. | 2010 | Mol. Pharmacol. | pmid:20837678 |
| Kumari U and Heese K | Cardiovascular dementia - a different perspective. | 2010 | Open Biochem J | pmid:20448820 |
| Crow JA et al. | Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. | 2010 | Biochim. Biophys. Acta | pmid:19761868 |
| DuSell CD et al. | The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. | 2010 | Endocrinology | pmid:20501668 |
| Ullrich C et al. | Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits. | 2010 | Mol. Cell. Neurosci. | pmid:20696249 |
| Marwarha G et al. | Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. | 2010 | J. Alzheimers Dis. | pmid:20157255 |
| Sniderman AD et al. | Regulation of plasma LDL: the apoB paradigm. | 2010 | Clin. Sci. | pmid:19922416 |
| Jenner AM et al. | The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. | 2010 | Neuroscience | pmid:20416362 |
| Taylor JM et al. | Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI. | 2010 | Cardiovasc. Res. | pmid:20083572 |
| Weingärtner O et al. | An alternative pathway of reverse cholesterol transport: the oxysterol 27-hydroxycholesterol. | 2010 | Atherosclerosis | pmid:19801147 |
| Seet RC et al. | Oxidative damage in Parkinson disease: Measurement using accurate biomarkers. | 2010 | Free Radic. Biol. Med. | pmid:19969070 |
| Schüle R et al. | Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. | 2010 | J. Lipid Res. | pmid:19812052 |
| Crisafulli C et al. | Effects of Liver x receptor agonist treatment on signal transduction pathways in acute lung inflammation. | 2010 | Respir. Res. | pmid:20175894 |
| Greenhill C | Bone: High 27-hydroxycholesterol decreases BMD. | 2010 | Nat Rev Endocrinol | pmid:20803803 |
| Schneider H et al. | A novel mutation in the sterol 27-hydroxylase gene of a woman with autosomal recessive cerebrotendinous xanthomatosis. | 2010 | Orphanet J Rare Dis | pmid:20925952 |
| Akram A et al. | Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis? | 2010 | Mol Neurodegener | pmid:20843353 |
| Seet RC et al. | Markers of oxidative damage are not elevated in otherwise healthy individuals with the metabolic syndrome. | 2010 | Diabetes Care | pmid:20185735 |
| Grinberg LT and Thal DR | Vascular pathology in the aged human brain. | 2010 | Acta Neuropathol. | pmid:20155424 |
| Olkkonen VM and Hynynen R | Interactions of oxysterols with membranes and proteins. | 2009 | Mol. Aspects Med. | pmid:19248802 |
| Gilardi F et al. | Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling. | 2009 | Neuroscience | pmid:19665519 |
| Trousson A et al. | Cross-talk between oxysterols and glucocorticoids: differential regulation of secreted phopholipase A2 and impact on oligodendrocyte death. | 2009 | PLoS ONE | pmid:19956653 |
| Solomon A et al. | Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease. | 2009 | Neurosci. Lett. | pmid:19560513 |
| Kim WS et al. | Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons. | 2009 | J. Alzheimers Dis. | pmid:19158428 |
| Morello F et al. | LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. | 2009 | Atherosclerosis | pmid:19426978 |
| Björkhem I et al. | Oxysterols and neurodegenerative diseases. | 2009 | Mol. Aspects Med. | pmid:19248803 |
| Hirayama T et al. | Serum concentration of 27-hydroxycholesterol predicts the effects of high-cholesterol diet on plasma LDL cholesterol level. | 2009 | Hepatol. Res. | pmid:19208035 |
| Seet RC et al. | Oxidative damage in dengue fever. | 2009 | Free Radic. Biol. Med. | pmid:19427377 |