Fu X et al. |
27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. |
2001 |
J. Biol. Chem. |
pmid:11504730
|
Ayaki Y et al. |
Cholic acid synthesis from 26-hydroxycholesterol and 3-hydroxy-5-cholestenoic acid in the rabbit. |
1989 |
J. Biol. Chem. |
pmid:2917979
|
Norlin M et al. |
Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A). |
2000 |
J. Biol. Chem. |
pmid:10882719
|
Manna PR et al. |
Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein. |
2013 |
J. Biol. Chem. |
pmid:23362264
|
Li-Hawkins J et al. |
Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. |
2000 |
J. Biol. Chem. |
pmid:10748047
|
Christenson LK et al. |
Oxysterol regulation of steroidogenic acute regulatory protein gene expression. Structural specificity and transcriptional and posttranscriptional actions. |
1998 |
J. Biol. Chem. |
pmid:9804848
|
Davies JD et al. |
Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells. |
2005 |
J. Biol. Chem. |
pmid:15548517
|
Mateos L et al. |
Side chain-oxidized oxysterols regulate the brain renin-angiotensin system through a liver X receptor-dependent mechanism. |
2011 |
J. Biol. Chem. |
pmid:21628469
|
Brown J et al. |
Differential expression of cholesterol hydroxylases in Alzheimer's disease. |
2004 |
J. Biol. Chem. |
pmid:15148325
|
Li J et al. |
De novo synthesis of steroids and oxysterols in adipocytes. |
2014 |
J. Biol. Chem. |
pmid:24280213
|
Pikuleva IA et al. |
Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways. |
1998 |
J. Biol. Chem. |
pmid:9660774
|
Zhang JH et al. |
The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. |
2011 |
J. Biol. Chem. |
pmid:21602275
|
Rojo L et al. |
Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease. |
2006 |
J. Biomed. Biotechnol. |
pmid:17047312
|
Ehrhardt M et al. |
Expression of human CYP27A1 in B. megaterium for the efficient hydroxylation of cholesterol, vitamin D3 and 7-dehydrocholesterol. |
2016 |
J. Biotechnol. |
pmid:26638999
|
Karuna R et al. |
Dopant assisted-atmospheric pressure photoionization (DA-APPI) liquid chromatography-mass spectrometry for the quantification of 27-hydroxycholesterol in plasma. |
2009 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:19121981
|
Jabara S et al. |
Stromal cells of the human postmenopausal ovary display a distinctive biochemical and molecular phenotype. |
2003 |
J. Clin. Endocrinol. Metab. |
pmid:12519894
|
Zhang JR et al. |
Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking. |
2008 |
J. Clin. Invest. |
pmid:18483620
|
Oguro H et al. |
27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. |
2017 |
J. Clin. Invest. |
pmid:28783041
|
Ismail MA et al. |
27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation. |
2017 |
J. Exp. Med. |
pmid:28213512
|
Hendrikx T et al. |
Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr(-/-) mice. |
2015 |
J. Hepatol. |
pmid:25281859
|
Strömsten A et al. |
Studies on the mechanism of accumulation of cholesterol in the gallbladder mucosa. Evidence that sterol 27-hydroxylase is not a pathogenetic factor. |
2004 |
J. Hepatol. |
pmid:14672608
|
Mignarri A et al. |
Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis. |
2016 |
J. Inherit. Metab. Dis. |
pmid:26153518
|
Björkhem I |
Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain. |
2006 |
J. Intern. Med. |
pmid:17116000
|
Hansson M et al. |
Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase. |
2007 |
J. Intern. Med. |
pmid:17444890
|
Duane WC and Javitt NB |
Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis? |
2002 |
J. Lab. Clin. Med. |
pmid:11919549
|
Wu Z et al. |
Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1. |
1999 |
J. Lipid Res. |
pmid:10588945
|
Reiss AB et al. |
Sterol 27-hydroxylase: expression in human arterial endothelium. |
1997 |
J. Lipid Res. |
pmid:9215552
|
Babiker A et al. |
Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin. |
1999 |
J. Lipid Res. |
pmid:10428977
|
Honda A et al. |
Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27(-/-) mice and CTX. |
2001 |
J. Lipid Res. |
pmid:11181760
|
Ali Z et al. |
On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice. |
2013 |
J. Lipid Res. |
pmid:23284090
|
Martin KO et al. |
7 alpha-hydroxylation of 27-hydroxycholesterol: biologic role in the regulation of cholesterol synthesis. |
1997 |
J. Lipid Res. |
pmid:9186922
|
Norlin M et al. |
24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A). |
2000 |
J. Lipid Res. |
pmid:11013305
|
Winegar DA et al. |
Effects of cyclosporin on cholesterol 27-hydroxylation and LDL receptor activity in HepG2 cells. |
1996 |
J. Lipid Res. |
pmid:8820113
|
Martin KO et al. |
Cholesterol and 27-hydroxycholesterol 7 alpha-hydroxylation: evidence for two different enzymes. |
1993 |
J. Lipid Res. |
pmid:8496664
|
Petrack B and Latario BJ |
Synthesis of 27-hydroxycholesterol in rat liver mitochondria: HPLC assay and marked activation by exogenous cholesterol. |
1993 |
J. Lipid Res. |
pmid:8496670
|
Meaney S et al. |
Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7alpha-hydroxy-3-oxo-4-cholestenoic acid. |
2007 |
J. Lipid Res. |
pmid:17251592
|
Honda A et al. |
Cholesterol 25-hydroxylation activity of CYP3A. |
2011 |
J. Lipid Res. |
pmid:21576599
|
Heverin M et al. |
Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain. |
2005 |
J. Lipid Res. |
pmid:15741649
|
Esterman AL et al. |
Cholesterol metabolism: use of D2O for determination of synthesis rate in cell culture. |
1985 |
J. Lipid Res. |
pmid:2995527
|
Björkhem I et al. |
Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol. |
2001 |
J. Lipid Res. |
pmid:11254748
|
Hong C et al. |
Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. |
2011 |
J. Lipid Res. |
pmid:21187453
|
Javitt NB |
26-Hydroxycholesterol: synthesis, metabolism, and biologic activities. |
1990 |
J. Lipid Res. |
pmid:2246606
|
Lee C et al. |
Bile acid synthesis: 7 alpha-hydroxylation of intermediates in the sterol 27-hydroxylase metabolic pathway. |
1996 |
J. Lipid Res. |
pmid:8808770
|
Li T et al. |
PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. |
2007 |
J. Lipid Res. |
pmid:17088262
|
Krisans SK et al. |
Bile acid synthesis in rat liver peroxisomes: metabolism of 26-hydroxycholesterol to 3 beta-hydroxy-5-cholenoic acid. |
1985 |
J. Lipid Res. |
pmid:4067421
|
Meaney S et al. |
On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function. |
2002 |
J. Lipid Res. |
pmid:12454275
|
Ni Y et al. |
Inhibitors of sterol synthesis. Tritium-labeled 26-hydroxycholesterol of high specific activity from a byproduct of the Clemmensen reduction of diosgenin. |
1994 |
J. Lipid Res. |
pmid:8014589
|
Leoni V et al. |
Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers. |
2003 |
J. Lipid Res. |
pmid:12562838
|
Axelson M et al. |
Structural specificity in the suppression of HMG-CoA reductase in human fibroblasts by intermediates in bile acid biosynthesis. |
1995 |
J. Lipid Res. |
pmid:7751816
|
Esterman AL et al. |
26-hydroxycholesterol: regulation of hydroxymethylglutaryl-CoA reductase activity in Chinese hamster ovary cell culture. |
1983 |
J. Lipid Res. |
pmid:6644180
|
Burkard I et al. |
Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry. |
2004 |
J. Lipid Res. |
pmid:14729854
|
McDonald JG et al. |
A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. |
2012 |
J. Lipid Res. |
pmid:22517925
|
Shafaati M et al. |
Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation. |
2011 |
J. Lipid Res. |
pmid:21335619
|
Reiss AB et al. |
Immune complexes and IFN-gamma decrease cholesterol 27-hydroxylase in human arterial endothelium and macrophages. |
2001 |
J. Lipid Res. |
pmid:11714861
|
Shentu TP et al. |
The role of oxysterols in control of endothelial stiffness. |
2012 |
J. Lipid Res. |
pmid:22496390
|
Zhang J et al. |
The steroidal analog GW707 activates the SREBP pathway through disruption of intracellular cholesterol trafficking. |
2004 |
J. Lipid Res. |
pmid:14617742
|
Meaney S et al. |
Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study. |
2001 |
J. Lipid Res. |
pmid:11160367
|
Heverin M et al. |
Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. |
2004 |
J. Lipid Res. |
pmid:14523054
|
Lange Y et al. |
Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol. |
2009 |
J. Lipid Res. |
pmid:19401598
|
Reiss AB et al. |
Sterol 27-hydroxylase: high levels of activity in vascular endothelium. |
1994 |
J. Lipid Res. |
pmid:8077842
|
Schüle R et al. |
Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. |
2010 |
J. Lipid Res. |
pmid:19812052
|
Del Puppo M et al. |
Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration. |
2001 |
J. Lipid Res. |
pmid:11254756
|
Meaney S et al. |
Serum cholestenoic acid as a potential marker of pulmonary cholesterol homeostasis: increased levels in patients with pulmonary alveolar proteinosis. |
2004 |
J. Lipid Res. |
pmid:15466366
|
Honda A et al. |
Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. |
2009 |
J. Lipid Res. |
pmid:18815436
|
Li X et al. |
Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes. |
2007 |
J. Lipid Res. |
pmid:17890683
|
Del Puppo M et al. |
Serum 27-hydroxycholesterol in patients with primary biliary cirrhosis suggests alteration of cholesterol catabolism to bile acids via the acidic pathway. |
1998 |
J. Lipid Res. |
pmid:9831637
|
Mistry HD et al. |
Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia. |
2017 |
J. Lipid Res. |
pmid:28396342
|
Duane WC and Javitt NB |
27-hydroxycholesterol: production rates in normal human subjects. |
1999 |
J. Lipid Res. |
pmid:10393204
|
Zhang Z et al. |
Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations. |
2001 |
J. Lipid Res. |
pmid:11290837
|
Norlin M |
Expression of key enzymes in bile acid biosynthesis during development: CYP7B1-mediated activities show tissue-specific differences. |
2002 |
J. Lipid Res. |
pmid:11971943
|
Perone Y and Magnani L |
Going off the grid: ERα breast cancer beyond estradiol. |
2016 |
J. Mol. Endocrinol. |
pmid:27151575
|
Marwarha G et al. |
The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease. |
2011 |
J. Neurochem. |
pmid:21951066
|
Rantham Prabhakara JP et al. |
Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells. |
2008 |
J. Neurochem. |
pmid:19014385
|
Popp J et al. |
Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease. |
2012 |
J. Neurochem. |
pmid:22845771
|
Mignarri A et al. |
Treatment of SPG5 with cholesterol-lowering drugs. |
2015 |
J. Neurol. |
pmid:26566916
|
Mignarri A et al. |
Hereditary spastic paraplegia type 5: a potentially treatable disorder of cholesterol metabolism. |
2014 |
J. Neurol. |
pmid:24509641
|
Novakova L et al. |
Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis. |
2015 |
J. Neurol. Sci. |
pmid:26342940
|
Glöckner F et al. |
Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice. |
2011 |
J. Neuropathol. Exp. Neurol. |
pmid:21412171
|
Makoukji J et al. |
Interplay between LXR and Wnt/β-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols. |
2011 |
J. Neurosci. |
pmid:21715627
|
Teunissen CE et al. |
24S-hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis. |
2007 |
J. Neurosci. Res. |
pmid:17410599
|
Brauner R et al. |
Phytosterols reduce cholesterol absorption by inhibition of 27-hydroxycholesterol generation, liver X receptor α activation, and expression of the basolateral sterol exporter ATP-binding cassette A1 in Caco-2 enterocytes. |
2012 |
J. Nutr. |
pmid:22535758
|
von Bahr S et al. |
Mutation in the sterol 27-hydroxylase gene associated with fatal cholestasis in infancy. |
2005 |
J. Pediatr. Gastroenterol. Nutr. |
pmid:15795599
|
Griffiths WJ et al. |
Discovering oxysterols in plasma: a window on the metabolome. |
2008 |
J. Proteome Res. |
pmid:18605750
|
Liao WL et al. |
Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain. |
2011 |
J. Proteome Res. |
pmid:21049985
|
Umetani M |
Re-adopting classical nuclear receptors by cholesterol metabolites. |
2016 |
J. Steroid Biochem. Mol. Biol. |
pmid:26563834
|
Wicher G and Norlin M |
Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis. |
2015 |
J. Steroid Biochem. Mol. Biol. |
pmid:25263657
|
Stellaard F et al. |
The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies. |
2017 |
J. Steroid Biochem. Mol. Biol. |
pmid:27060336
|
Zhang X et al. |
Cholesterol metabolite, 5-cholesten-3β-25-diol-3-sulfate, promotes hepatic proliferation in mice. |
2012 |
J. Steroid Biochem. Mol. Biol. |
pmid:22732306
|
Cardenia V et al. |
Effect of broccoli extract enriched diet on liver cholesterol oxidation in rats subjected to exhaustive exercise. |
2017 |
J. Steroid Biochem. Mol. Biol. |
pmid:27084531
|
Kim BY et al. |
27-Hydroxycholesterol upregulates the production of heat shock protein 60 of monocytic cells. |
2017 |
J. Steroid Biochem. Mol. Biol. |
pmid:28549691
|
Roberg-Larsen H et al. |
Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes. |
2017 |
J. Steroid Biochem. Mol. Biol. |
pmid:26877254
|
Heverin M et al. |
On the regulatory importance of 27-hydroxycholesterol in mouse liver. |
2017 |
J. Steroid Biochem. Mol. Biol. |
pmid:26851362
|
Ichinose L |
Possible new regulator of atherosclerosis is found. |
1982 |
JAMA |
pmid:7087117
|
Zhou Q et al. |
27-Hydroxycholesterol inhibits neutral sphingomyelinase in cultured human endothelial cells. |
2004 |
Life Sci. |
pmid:15261762
|
Kummerow FA et al. |
27-Hydroxycholesterol causes remodeling in endothelial cell membrane lipid composition comparable to remodeling in the failed vein grafts of CABG patients. |
2006 |
Life Sci. |
pmid:16154158
|
Hall EA et al. |
Mitochondrial cholesterol transport: a possible target in the management of hyperlipidemia. |
2005 |
Lipids |
pmid:16477808
|
Wang YM et al. |
The mechanism of dietary cholesterol effects on lipids metabolism in rats. |
2010 |
Lipids Health Dis |
pmid:20070910
|
Iborra RT et al. |
Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. |
2011 |
Lipids Health Dis |
pmid:21957962
|
Jusakul A et al. |
Mechanisms of oxysterol-induced carcinogenesis. |
2011 |
Lipids Health Dis |
pmid:21388551
|
Bohr IJ |
Does cholesterol act as a protector of cholinergic projections in Alzheimer's disease? |
2005 |
Lipids Health Dis |
pmid:15949039
|