26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.
To understand associated biological information of 26-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
26-Hydroxycholesterol is suspected in hypercholesterolemia, Obesity, Atherosclerosis, Metabolic syndrome, Neurodegenerative Disorders, Dyslipidemias and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 26-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cholesterol and breast cancer pathophysiology.' (Nelson ER et al., 2014) and Transgenic Model are used in the study 'Obesity, cholesterol metabolism, and breast cancer pathogenesis.' (McDonnell DP et al., 2014).
Knock-out are used in the study 'The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.' (Umetani M et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Williams JR et al. | Synthesis of (25R)-26-hydroxycholesterol. | 2002 | Steroids | pmid:12441189 |
| Meaney S et al. | On the origin of the cholestenoic acids in human circulation. | 2003 | Steroids | pmid:12957664 |
| Jabara S et al. | Stromal cells of the human postmenopausal ovary display a distinctive biochemical and molecular phenotype. | 2003 | J. Clin. Endocrinol. Metab. | pmid:12519894 |
| Tuomainen TP et al. | Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man. | 2003 | Free Radic. Biol. Med. | pmid:14556856 |
| Hansson M et al. | Marked induction of sterol 27-hydroxylase activity and mRNA levels during differentiation of human cultured monocytes into macrophages. | 2003 | Biochim. Biophys. Acta | pmid:12581873 |
| Leoni V et al. | Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers. | 2003 | J. Lipid Res. | pmid:12562838 |
| Guan JZ et al. | Clofibrate, a peroxisome-proliferator, enhances reverse cholesterol transport through cytochrome P450 activation and oxysterol generation. | 2003 | Tohoku J. Exp. Med. | pmid:14690017 |
| Frolov A et al. | NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols. | 2003 | J. Biol. Chem. | pmid:12719428 |
| Souidi M et al. | Effects of dietary 27-hydroxycholesterol on cholesterol metabolism and bile acid biosynthesis in the hamster. | 2003 | Can. J. Physiol. Pharmacol. | pmid:14614521 |
| Pikuleva I and Javitt NB | Novel sterols synthesized via the CYP27A1 metabolic pathway. | 2003 | Arch. Biochem. Biophys. | pmid:14622972 |
| Ciuffreda P et al. | Synthesis of deuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids. | 2003 | Steroids | pmid:14625005 |
| Escher G et al. | Expression of sterol 27-hydroxylase (CYP27A1) enhances cholesterol efflux. | 2003 | J. Biol. Chem. | pmid:12531903 |
| Wassif CA et al. | 27-Hydroxylation of 7- and 8-dehydrocholesterol in Smith-Lemli-Opitz syndrome: a novel metabolic pathway. | 2003 | Steroids | pmid:12906934 |
| Yoshida T et al. | Origin of oxysterols in hepatic bile of patients with biliary infection. | 2003 | Am. J. Gastroenterol. | pmid:14572579 |
| Teunissen CE et al. | Serum cholesterol, precursors and metabolites and cognitive performance in an aging population. | 2003 Jan-Feb | Neurobiol. Aging | pmid:12493560 |
| Matyash V et al. | Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16. | 2004 | PLoS Biol. | pmid:15383841 |
| Szanto A et al. | Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophages. | 2004 | Mol. Cell. Biol. | pmid:15340076 |
| Zhou Q et al. | 27-Hydroxycholesterol inhibits neutral sphingomyelinase in cultured human endothelial cells. | 2004 | Life Sci. | pmid:15261762 |
| Holdenrieder S et al. | Does brain specific 24S-hydroxycholesterol in plasma indicate the disruption of the blood-brain barrier in patients with ischemic stroke? | 2004 | Neurosci. Lett. | pmid:15351449 |
| Strömsten A et al. | Studies on the mechanism of accumulation of cholesterol in the gallbladder mucosa. Evidence that sterol 27-hydroxylase is not a pathogenetic factor. | 2004 | J. Hepatol. | pmid:14672608 |
| Kölsch H et al. | Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients. | 2004 | Neurosci. Lett. | pmid:15364416 |
| Leoni V et al. | Diagnostic use of cerebral and extracerebral oxysterols. | 2004 | Clin. Chem. Lab. Med. | pmid:15061359 |
| Alessandrini L et al. | Clemmensen reduction of diosgenin and kryptogenin: synthesis of [16,16,22,22,23,23-(2)H(6)]-(25R)-26-hydroxycholesterol. | 2004 | Steroids | pmid:15582533 |
| Burkard I et al. | Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry. | 2004 | J. Lipid Res. | pmid:14729854 |
| Brown J et al. | Differential expression of cholesterol hydroxylases in Alzheimer's disease. | 2004 | J. Biol. Chem. | pmid:15148325 |
| Zhang J et al. | The steroidal analog GW707 activates the SREBP pathway through disruption of intracellular cholesterol trafficking. | 2004 | J. Lipid Res. | pmid:14617742 |
| Heverin M et al. | Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. | 2004 | J. Lipid Res. | pmid:14523054 |
| Honda A et al. | Significance of plasma 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits. | 2004 | Metab. Clin. Exp. | pmid:14681840 |
| Meaney S et al. | Serum cholestenoic acid as a potential marker of pulmonary cholesterol homeostasis: increased levels in patients with pulmonary alveolar proteinosis. | 2004 | J. Lipid Res. | pmid:15466366 |
| Lemaire-Ewing S et al. | Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. | 2005 | Cell Biol. Toxicol. | pmid:16142584 |
| Babiker A et al. | Patients with atherosclerosis may have increased circulating levels of 27-hydroxycholesterol and cholestenoic acid. | 2005 | Scand. J. Clin. Lab. Invest. | pmid:16081359 |
| Heverin M et al. | Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain. | 2005 | J. Lipid Res. | pmid:15741649 |
| Hall EA et al. | Detection of the steroidogenic acute regulatory protein, StAR, in human liver cells. | 2005 | Biochim. Biophys. Acta | pmid:15863358 |
| Hansson M et al. | Regulation of sterol 27-hydroxylase in human monocyte-derived macrophages: up-regulation by transforming growth factor beta1. | 2005 | Biochim. Biophys. Acta | pmid:15708352 |
| Davies JD et al. | Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells. | 2005 | J. Biol. Chem. | pmid:15548517 |
| Del Puppo M et al. | A minimally invasive technique for the evaluation of the regulatory steps of the two major pathways of bile acid synthesis. | 2005 | Clin. Chim. Acta | pmid:15820474 |
| Bohr IJ | Does cholesterol act as a protector of cholinergic projections in Alzheimer's disease? | 2005 | Lipids Health Dis | pmid:15949039 |
| Zhu Y et al. | Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR). | 2005 | Cardiovasc. Res. | pmid:16099444 |
| Hall EA et al. | Mitochondrial cholesterol transport: a possible target in the management of hyperlipidemia. | 2005 | Lipids | pmid:16477808 |
| von Bahr S et al. | Mutation in the sterol 27-hydroxylase gene associated with fatal cholestasis in infancy. | 2005 | J. Pediatr. Gastroenterol. Nutr. | pmid:15795599 |
| Meaney S | Is C-26 hydroxylation an evolutionarily conserved steroid inactivation mechanism? | 2005 | FASEB J. | pmid:16051688 |
| Björkhem I | Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain. | 2006 | J. Intern. Med. | pmid:17116000 |
| Pikuleva IA | Cholesterol-metabolizing cytochromes P450. | 2006 | Drug Metab. Dispos. | pmid:16434543 |
| Klass DM et al. | Biliary lipids, cholesterol and bile synthesis: different adaptive mechanisms to dietary cholesterol in lean and obese subjects. | 2006 | Aliment. Pharmacol. Ther. | pmid:16573792 |
| Rojo L et al. | Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease. | 2006 | J. Biomed. Biotechnol. | pmid:17047312 |
| Björkhem I et al. | Oxysterols and Alzheimer's disease. | 2006 | Acta Neurol. Scand., Suppl.c | pmid:16866910 |
| Larsson DA et al. | Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects. | 2006 | Free Radic. Biol. Med. | pmid:16934673 |
| Dushkin MI et al. | Effects of hydroxysterols and atorvastatin on lipopolysaccharide-induced secretion of tumor necrosis factor and interleukin-10 by mouse macrophages. | 2006 | Bull. Exp. Biol. Med. | pmid:16984105 |
| Luomala M et al. | Plasma-soluble CD40 is related to cholesterol metabolism in patients with moderate hypercholesterolemia. | 2006 | Scand. Cardiovasc. J. | pmid:17012138 |
| Holzapfel J et al. | PPARD haplotype influences cholesterol metabolism but is no risk factor of Alzheimer's disease. | 2006 | Neurosci. Lett. | pmid:16979821 |