26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.
To understand associated biological information of 26-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
26-Hydroxycholesterol is suspected in hypercholesterolemia, Obesity, Atherosclerosis, Metabolic syndrome, Neurodegenerative Disorders, Dyslipidemias and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 26-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cholesterol and breast cancer pathophysiology.' (Nelson ER et al., 2014) and Transgenic Model are used in the study 'Obesity, cholesterol metabolism, and breast cancer pathogenesis.' (McDonnell DP et al., 2014).
Knock-out are used in the study 'The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.' (Umetani M et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Glöckner F et al. | Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice. | 2011 | J. Neuropathol. Exp. Neurol. | pmid:21412171 |
| Gamba P et al. | Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. | 2011 | Aging Cell | pmid:21272192 |
| Karuna R et al. | Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism. | 2011 | Atherosclerosis | pmid:21130455 |
| Iborra RT et al. | Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. | 2011 | Lipids Health Dis | pmid:21957962 |
| Jeitner TM et al. | Oxysterol derivatives of cholesterol in neurodegenerative disorders. | 2011 | Curr. Med. Chem. | pmid:21428891 |
| Prasanthi JR et al. | Silencing GADD153/CHOP gene expression protects against Alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus. | 2011 | PLoS ONE | pmid:22046282 |
| Hong C et al. | Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. | 2011 | J. Lipid Res. | pmid:21187453 |
| Huwait EA et al. | A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression. | 2011 | Cell. Signal. | pmid:21070853 |
| Lappano R et al. | The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes. | 2011 | PLoS ONE | pmid:21304949 |
| Baker ME | Insights from the structure of estrogen receptor into the evolution of estrogens: implications for endocrine disruption. | 2011 | Biochem. Pharmacol. | pmid:21420388 |
| Shafaati M et al. | Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation. | 2011 | J. Lipid Res. | pmid:21335619 |
| Seet RC et al. | Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? | 2011 | Free Radic. Biol. Med. | pmid:21420490 |
| Mast N et al. | Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:20881306 |
| Leoni V and Caccia C | Oxysterols as biomarkers in neurodegenerative diseases. | 2011 | Chem. Phys. Lipids | pmid:21515244 |
| Liao WL et al. | Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain. | 2011 | J. Proteome Res. | pmid:21049985 |
| Leoni V et al. | Whole body cholesterol metabolism is impaired in Huntington's disease. | 2011 | Neurosci. Lett. | pmid:21406216 |
| Crosignani A et al. | Oxysterols in bile acid metabolism. | 2011 | Clin. Chim. Acta | pmid:21855537 |
| Bełtowski J and Semczuk A | Liver X receptor (LXR) and the reproductive system--a potential novel target for therapeutic intervention. | 2010 Jan-Feb | Pharmacol Rep | pmid:20360612 |
| Vallim T and Salter AM | Regulation of hepatic gene expression by saturated fatty acids. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20227267 |
| Kölsch H et al. | Alterations of cholesterol precursor levels in Alzheimer's disease. | 2010 | Biochim. Biophys. Acta | pmid:20226877 |
| Blom T et al. | FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. | 2010 | Circ. Res. | pmid:20056921 |
| Wang YM et al. | The mechanism of dietary cholesterol effects on lipids metabolism in rats. | 2010 | Lipids Health Dis | pmid:20070910 |
| Dasari B et al. | The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. | 2010 | BMC Ophthalmol | pmid:20836858 |
| Berrodin TJ et al. | Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity. | 2010 | Mol. Pharmacol. | pmid:20837678 |
| Kumari U and Heese K | Cardiovascular dementia - a different perspective. | 2010 | Open Biochem J | pmid:20448820 |
| Crow JA et al. | Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. | 2010 | Biochim. Biophys. Acta | pmid:19761868 |
| DuSell CD et al. | The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. | 2010 | Endocrinology | pmid:20501668 |
| Ullrich C et al. | Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits. | 2010 | Mol. Cell. Neurosci. | pmid:20696249 |
| Marwarha G et al. | Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices. | 2010 | J. Alzheimers Dis. | pmid:20157255 |
| Sniderman AD et al. | Regulation of plasma LDL: the apoB paradigm. | 2010 | Clin. Sci. | pmid:19922416 |
| Jenner AM et al. | The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. | 2010 | Neuroscience | pmid:20416362 |
| Taylor JM et al. | Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI. | 2010 | Cardiovasc. Res. | pmid:20083572 |
| Weingärtner O et al. | An alternative pathway of reverse cholesterol transport: the oxysterol 27-hydroxycholesterol. | 2010 | Atherosclerosis | pmid:19801147 |
| Seet RC et al. | Oxidative damage in Parkinson disease: Measurement using accurate biomarkers. | 2010 | Free Radic. Biol. Med. | pmid:19969070 |
| Schüle R et al. | Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. | 2010 | J. Lipid Res. | pmid:19812052 |
| Crisafulli C et al. | Effects of Liver x receptor agonist treatment on signal transduction pathways in acute lung inflammation. | 2010 | Respir. Res. | pmid:20175894 |
| Greenhill C | Bone: High 27-hydroxycholesterol decreases BMD. | 2010 | Nat Rev Endocrinol | pmid:20803803 |
| Schneider H et al. | A novel mutation in the sterol 27-hydroxylase gene of a woman with autosomal recessive cerebrotendinous xanthomatosis. | 2010 | Orphanet J Rare Dis | pmid:20925952 |
| Akram A et al. | Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis? | 2010 | Mol Neurodegener | pmid:20843353 |
| Seet RC et al. | Markers of oxidative damage are not elevated in otherwise healthy individuals with the metabolic syndrome. | 2010 | Diabetes Care | pmid:20185735 |
| Grinberg LT and Thal DR | Vascular pathology in the aged human brain. | 2010 | Acta Neuropathol. | pmid:20155424 |
| Riendeau V and Garenc C | Effect of 27-hydroxycholesterol on survival and death of human macrophages and vascular smooth muscle cells. | 2009 | Free Radic. Res. | pmid:19672739 |
| Olkkonen VM and Hynynen R | Interactions of oxysterols with membranes and proteins. | 2009 | Mol. Aspects Med. | pmid:19248802 |
| Gilardi F et al. | Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling. | 2009 | Neuroscience | pmid:19665519 |
| Lütjohann D et al. | 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man. | 2009 | Int J Clin Pharmacol Ther | pmid:19954708 |
| Trousson A et al. | Cross-talk between oxysterols and glucocorticoids: differential regulation of secreted phopholipase A2 and impact on oligodendrocyte death. | 2009 | PLoS ONE | pmid:19956653 |
| Solomon A et al. | Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease. | 2009 | Neurosci. Lett. | pmid:19560513 |
| Morello F et al. | LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. | 2009 | Atherosclerosis | pmid:19426978 |
| Björkhem I et al. | Oxysterols and neurodegenerative diseases. | 2009 | Mol. Aspects Med. | pmid:19248803 |
| Seet RC et al. | Oxidative damage in dengue fever. | 2009 | Free Radic. Biol. Med. | pmid:19427377 |