26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.
To understand associated biological information of 26-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
26-Hydroxycholesterol is suspected in hypercholesterolemia, Obesity, Atherosclerosis, Metabolic syndrome, Neurodegenerative Disorders, Dyslipidemias and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 26-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammation | D007249 | 119 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cholesterol and breast cancer pathophysiology.' (Nelson ER et al., 2014) and Transgenic Model are used in the study 'Obesity, cholesterol metabolism, and breast cancer pathogenesis.' (McDonnell DP et al., 2014).
Knock-out are used in the study 'The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.' (Umetani M et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Karuna R et al. | Dopant assisted-atmospheric pressure photoionization (DA-APPI) liquid chromatography-mass spectrometry for the quantification of 27-hydroxycholesterol in plasma. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19121981 |
| Escher G et al. | Role of CYP27A1 in progesterone metabolism in vitro and in vivo. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19671838 |
| Li T and Chiang JY | Regulation of bile acid and cholesterol metabolism by PPARs. | 2009 | PPAR Res | pmid:19636418 |
| Mateos L et al. | Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro. | 2009 | Brain Pathol. | pmid:18503570 |
| Wang Y et al. | Targeted lipidomic analysis of oxysterols in the embryonic central nervous system. | 2009 | Mol Biosyst | pmid:19381367 |
| Zhou C et al. | The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. | 2009 | Nucl Recept Signal | pmid:19240808 |
| Prasanthi JR et al. | Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. | 2009 | Mol Neurodegener | pmid:19126211 |
| Koschack J et al. | Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals. | 2009 | Neurobiol. Aging | pmid:18061309 |
| Mathieu JM et al. | Medical bioremediation of age-related diseases. | 2009 | Microb. Cell Fact. | pmid:19358742 |
| Lange Y et al. | Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol. | 2009 | J. Lipid Res. | pmid:19401598 |
| van den Kommer TN et al. | Total cholesterol and oxysterols: early markers for cognitive decline in elderly? | 2009 | Neurobiol. Aging | pmid:17888546 |
| Honda A et al. | Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. | 2009 | J. Lipid Res. | pmid:18815436 |
| Kim WS et al. | Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons. | 2009 | J. Alzheimers Dis. | pmid:19158428 |
| Hirayama T et al. | Serum concentration of 27-hydroxycholesterol predicts the effects of high-cholesterol diet on plasma LDL cholesterol level. | 2009 | Hepatol. Res. | pmid:19208035 |
| Tang W et al. | Glucocorticoid receptor-mediated upregulation of human CYP27A1, a potential anti-atherogenic enzyme. | 2008 Nov-Dec | Biochim. Biophys. Acta | pmid:18817892 |
| Patel MB et al. | Liver x receptor: a novel therapeutic target. | 2008 Mar-Apr | Indian J Pharm Sci | pmid:20046702 |
| Mosig S et al. | Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism. | 2008 | BMC Med Genomics | pmid:19040724 |
| de Vogel-van den Bosch HM et al. | A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18356535 |
| Weiner MF et al. | Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury. | 2008 | Brain Inj | pmid:18568715 |
| Ghribi O | Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle. | 2008 | J. Alzheimers Dis. | pmid:19096164 |
| Cheng D et al. | Regulation of alpha-synuclein expression by liver X receptor ligands in vitro. | 2008 | Neuroreport | pmid:18841091 |
| Lange Y et al. | Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase. | 2008 | J. Biol. Chem. | pmid:18024962 |
| Zhang JR et al. | Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking. | 2008 | J. Clin. Invest. | pmid:18483620 |
| DuSell CD et al. | 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. | 2008 | Mol. Endocrinol. | pmid:17872378 |
| Crosignani A et al. | Plasma oxysterols in normal and cholestatic children as indicators of the two pathways of bile acid synthesis. | 2008 | Clin. Chim. Acta | pmid:18538136 |
| Lee CY et al. | Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample. | 2008 | Free Radic. Biol. Med. | pmid:18226605 |
| Rantham Prabhakara JP et al. | Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells. | 2008 | J. Neurochem. | pmid:19014385 |
| Yoshida T et al. | Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry. | 2008 | Anal Chem Insights | pmid:19609389 |
| Griffiths WJ et al. | Discovering oxysterols in plasma: a window on the metabolome. | 2008 | J. Proteome Res. | pmid:18605750 |
| Sharma S et al. | Hypercholesterolemia-induced Abeta accumulation in rabbit brain is associated with alteration in IGF-1 signaling. | 2008 | Neurobiol. Dis. | pmid:18775495 |
| DuSell CD and McDonnell DP | 27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling. | 2008 | Trends Pharmacol. Sci. | pmid:18722677 |
| DiBlasio-Smith EA et al. | Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. | 2008 | J Transl Med | pmid:18925943 |
| Szatmari I and Nagy L | Nuclear receptor signalling in dendritic cells connects lipids, the genome and immune function. | 2008 | EMBO J. | pmid:18716631 |
| Duron E and Hanon O | Vascular risk factors, cognitive decline, and dementia. | 2008 | Vasc Health Risk Manag | pmid:18561512 |
| Chen W et al. | Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. | 2007 | Cell Metab. | pmid:17189208 |
| Hojo K et al. | Determination of total cholesterol in serum by high-performance liquid chromatography with electrochemical detection. | 2007 | J Chromatogr A | pmid:17723233 |
| Meaney S et al. | Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7alpha-hydroxy-3-oxo-4-cholestenoic acid. | 2007 | J. Lipid Res. | pmid:17251592 |
| Gueguen Y et al. | Compared effect of immunosuppressive drugs cyclosporine A and rapamycin on cholesterol homeostasis key enzymes CYP27A1 and HMG-CoA reductase. | 2007 | Basic Clin. Pharmacol. Toxicol. | pmid:17516993 |
| Li T et al. | PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. | 2007 | J. Lipid Res. | pmid:17088262 |
| Teunissen CE et al. | 24S-hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis. | 2007 | J. Neurosci. Res. | pmid:17410599 |
| Hansson M et al. | Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase. | 2007 | J. Intern. Med. | pmid:17444890 |
| Jiang X et al. | Characterization of oxysterols by electrospray ionization tandem mass spectrometry after one-step derivatization with dimethylglycine. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17154356 |
| Burkard I et al. | Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers. | 2007 | Atherosclerosis | pmid:17107679 |
| Luomala M et al. | Osteopontin levels are associated with cholesterol synthesis markers in mildly hypercholesterolaemic patients. | 2007 | Acta Cardiol | pmid:17536607 |
| Crosignani A et al. | Changes in classic and alternative pathways of bile acid synthesis in chronic liver disease. | 2007 | Clin. Chim. Acta | pmid:17482152 |
| Li X et al. | Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes. | 2007 | J. Lipid Res. | pmid:17890683 |
| Umetani M et al. | 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. | 2007 | Nat. Med. | pmid:17873880 |
| van den Bosch HM et al. | Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting. | 2007 | BMC Genomics | pmid:17683626 |
| Larsson DA et al. | Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects. | 2006 | Free Radic. Biol. Med. | pmid:16934673 |
| Holzapfel J et al. | PPARD haplotype influences cholesterol metabolism but is no risk factor of Alzheimer's disease. | 2006 | Neurosci. Lett. | pmid:16979821 |