MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Abnormalities, Multiple | D000015 | 13 associated lipids |
Intellectual Disability | D008607 | 13 associated lipids |
Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
7-Dehydrocholesterol is a lipid of Sterol Lipids (ST) class. 7-dehydrocholesterol is associated with abnormalities such as Dehydration, Exanthema, RETINITIS PIGMENTOSA 49, Congenital Abnormality and Failure to Thrive. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Mutation, Lysis, Anabolism and Biosynthetic Pathways. 7-dehydrocholesterol often locates in Plasma membrane, Body tissue, Tissue membrane, Membrane and outer membrane. The associated genes with 7-Dehydrocholesterol are mutant gene, THEMIS gene, IGKV1D-37 gene, LGALS4 gene and Orthologous Gene. The related lipids are Membrane Lipids, Steroids, Sterols, campesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out and Rodent Model.
To understand associated biological information of 7-Dehydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Dehydrocholesterol is suspected in Dehydration, Congenital Abnormality, Exanthema, Vitamin D Deficiency, Retinal Degeneration, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 7-Dehydrocholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Abnormalities, Multiple | D000015 | 13 associated lipids |
Intellectual Disability | D008607 | 13 associated lipids |
Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 7-Dehydrocholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome.' (Xu L et al., 2011) and Mouse Model are used in the study 'Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells.' (Xu L et al., 2013).
Knock-out are used in the study 'Immunoglobulin E receptor signaling and asthma.' (Wu LC, 2011) and Knock-out are used in the study 'Novel activities of CYP11A1 and their potential physiological significance.' (Slominski AT et al., 2015).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014) and Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Al-Owain M et al. | Smith-Lemli-Opitz syndrome among Arabs. | 2012 | Clin. Genet. | pmid:21696385 |
Hu P et al. | Fibroblast growth factor-23 helps explain the biphasic cardiovascular effects of vitamin D in chronic kidney disease. | 2012 | Int. J. Biol. Sci. | pmid:22606047 |
Shaygannejad V et al. | Effects of adjunct low-dose vitamin d on relapsing-remitting multiple sclerosis progression: preliminary findings of a randomized placebo-controlled trial. | 2012 | Mult Scler Int | pmid:22567287 |
Reinholz M et al. | Cathelicidin LL-37: an antimicrobial peptide with a role in inflammatory skin disease. | 2012 | Ann Dermatol | pmid:22577261 |
Campbell GR and Spector SA | Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy. | 2012 | PLoS Pathog. | pmid:22589721 |
Diezi TA and Kwon G | Amphotericin B/sterol co-loaded PEG-phospholipid micelles: effects of sterols on aggregation state and hemolytic activity of amphotericin B. | 2012 | Pharm. Res. | pmid:22130733 |
Bei WJ et al. | Lipid-regulating effect of traditional chinese medicine: mechanisms of actions. | 2012 | Evid Based Complement Alternat Med | pmid:22611438 |
Binkhorst M et al. | Glycosylation defects underlying fetal alcohol spectrum disorder: a novel pathogenetic model. "When the wine goes in, strange things come out" - S.T. Coleridge, The Piccolomini. | 2012 | J. Inherit. Metab. Dis. | pmid:22134542 |
Nowaczyk MJ and Irons MB | Smith-Lemli-Opitz syndrome: phenotype, natural history, and epidemiology. | 2012 | Am J Med Genet C Semin Med Genet | pmid:23059950 |
Waterham HR and Hennekam RC | Mutational spectrum of Smith-Lemli-Opitz syndrome. | 2012 | Am J Med Genet C Semin Med Genet | pmid:23042628 |