Dihydrocholesterol is a lipid of Sterol Lipids (ST) class. Dihydrocholesterol is associated with abnormalities such as Exanthema, Morphologically altered structure, protrusion, Dehydration and Xanthoma. The involved functions are known as Regulation, Biochemical Pathway, Methylation, Metabolic Inhibition and Biosynthetic Pathways. Dihydrocholesterol often locates in envelope, Mitochondria, Lipid Bilayers, Host Cell and Membrane. The associated genes with Dihydrocholesterol are GRAP2 gene, PTP4A2 gene, HSD3B7 gene, MBD2 gene and IGF2BP3 gene. The related lipids are Sterols, Cardiolipins, Pregnanes, 7-hydroxy-4-cholesten-3-one and Hydroxycholesterols. The related experimental models are Mouse Model.
To understand associated biological information of Dihydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Dihydrocholesterol is suspected in Xanthoma, Xanthomatosis, Cerebrotendinous, Coronary heart disease, Exanthema, Morphologically altered structure, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Dihydrocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcoholism | D000437 | 27 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase.' (BÃ¥vner A et al., 2010).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cabral AC et al. | An integrated evaluation of some faecal indicator bacteria (FIB) and chemical markers as potential tools for monitoring sewage contamination in subtropical estuaries. | 2018 | Environ. Pollut. | pmid:29339343 |
| Othman RA et al. | Thyroid Hormone Status in Sitosterolemia Is Modified by Ezetimibe. | 2017 | J. Pediatr. | pmid:28625503 |
| Alhariri A et al. | Clinical report: A patient with a late diagnosis of cerebrotendinous xanthomatosis and a response to treatment. | 2017 | Am. J. Med. Genet. A | pmid:28590052 |
| Mast N et al. | Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum. | 2017 | J. Biol. Chem. | pmid:28190002 |
| Tibrewal S et al. | Cerebrotendinous xanthomatosis: early diagnosis on the basis of juvenile cataracts. | 2017 | J AAPOS | pmid:29079218 |
| Chen C et al. | Clinical and molecular genetic features of cerebrotendinous xanthomatosis patients in Chinese families. | 2017 | Metab Brain Dis | pmid:28623566 |
| Reis SA et al. | Mechanisms responsible for the hypocholesterolaemic effect of regular consumption of probiotics. | 2017 | Nutr Res Rev | pmid:27995830 |
| Andrade I et al. | Cholesterol absorption and synthesis markers in Portuguese hypercholesterolemic adults: A cross-sectional study. | 2016 | Eur. J. Intern. Med. | pmid:26577223 |
| Rada JPA et al. | Sewage contamination of sediments from two Portuguese Atlantic coastal systems, revealed by fecal sterols. | 2016 | Mar. Pollut. Bull. | pmid:26778497 |
| Valayil JM et al. | Isolation, Purification and Characterization of a Novel Steroidal Saponin Cholestanol Glucoside from Lasiodiplodia theobromae that Induces Apoptosis in A549 Cells. | 2016 | Anticancer Agents Med Chem | pmid:26338072 |