Dihydrocholesterol

Dihydrocholesterol is a lipid of Sterol Lipids (ST) class. Dihydrocholesterol is associated with abnormalities such as Exanthema, Morphologically altered structure, protrusion, Dehydration and Xanthoma. The involved functions are known as Regulation, Biochemical Pathway, Methylation, Metabolic Inhibition and Biosynthetic Pathways. Dihydrocholesterol often locates in envelope, Mitochondria, Lipid Bilayers, Host Cell and Membrane. The associated genes with Dihydrocholesterol are GRAP2 gene, PTP4A2 gene, HSD3B7 gene, MBD2 gene and IGF2BP3 gene. The related lipids are Sterols, Cardiolipins, Pregnanes, 7-hydroxy-4-cholesten-3-one and Hydroxycholesterols. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Dihydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Dihydrocholesterol?

Dihydrocholesterol is suspected in Xanthoma, Xanthomatosis, Cerebrotendinous, Coronary heart disease, Exanthema, Morphologically altered structure, Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Dihydrocholesterol

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Cataract D002386 34 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Alcoholism D000437 27 associated lipids
Brain Diseases, Metabolic D001928 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Xanthomatosis D014973 17 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 9

PubChem Associated disorders and diseases

What pathways are associated with Dihydrocholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Dihydrocholesterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Dihydrocholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Dihydrocholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Dihydrocholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Dihydrocholesterol?

Mouse Model

Mouse Model are used in the study 'On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase.' (BÃ¥vner A et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Dihydrocholesterol

Download all related citations
Per page 10 20 50 100 | Total 471
Authors Title Published Journal PubMed Link
Cabral AC et al. An integrated evaluation of some faecal indicator bacteria (FIB) and chemical markers as potential tools for monitoring sewage contamination in subtropical estuaries. 2018 Environ. Pollut. pmid:29339343
Othman RA et al. Thyroid Hormone Status in Sitosterolemia Is Modified by Ezetimibe. 2017 J. Pediatr. pmid:28625503
Alhariri A et al. Clinical report: A patient with a late diagnosis of cerebrotendinous xanthomatosis and a response to treatment. 2017 Am. J. Med. Genet. A pmid:28590052
Mast N et al. Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum. 2017 J. Biol. Chem. pmid:28190002
Tibrewal S et al. Cerebrotendinous xanthomatosis: early diagnosis on the basis of juvenile cataracts. 2017 J AAPOS pmid:29079218
Chen C et al. Clinical and molecular genetic features of cerebrotendinous xanthomatosis patients in Chinese families. 2017 Metab Brain Dis pmid:28623566
Reis SA et al. Mechanisms responsible for the hypocholesterolaemic effect of regular consumption of probiotics. 2017 Nutr Res Rev pmid:27995830
Mignarri A et al. Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis. 2016 J. Inherit. Metab. Dis. pmid:26153518
Andrade I et al. Cholesterol absorption and synthesis markers in Portuguese hypercholesterolemic adults: A cross-sectional study. 2016 Eur. J. Intern. Med. pmid:26577223
Koyama S and Kato T Pathophysiology of cerebrotendinous xanthomatosis. 2016 Rinsho Shinkeigaku pmid:27840382
Koge J et al. A case of cerebrotendinous xanthomatosis mimicking the clinical phenotype of mitochondrial disease with a novel frame-shift mutation (c. 43_44 delGG) in CYP27A1 gene exon 1. 2016 Rinsho Shinkeigaku pmid:27680221
Mattis CE and Mootoo DR A ring closing metathesis strategy for carbapyranosides of xylose and arabinose. 2016 Carbohydr. Res. pmid:27236269
Frena M et al. Evaluation of anthropogenic contamination using sterol markers in a tropical estuarine system of northeast Brazil. 2016 Mar. Pollut. Bull. pmid:27207024
Matić Bujagić I et al. Sterol ratios as a tool for sewage pollution assessment of river sediments in Serbia. 2016 Environ. Pollut. pmid:26874877
Rada JPA et al. Sewage contamination of sediments from two Portuguese Atlantic coastal systems, revealed by fecal sterols. 2016 Mar. Pollut. Bull. pmid:26778497
Valayil JM et al. Isolation, Purification and Characterization of a Novel Steroidal Saponin Cholestanol Glucoside from Lasiodiplodia theobromae that Induces Apoptosis in A549 Cells. 2016 Anticancer Agents Med Chem pmid:26338072
Antharam VC et al. An Integrated Metabolomic and Microbiome Analysis Identified Specific Gut Microbiota Associated with Fecal Cholesterol and Coprostanol in Clostridium difficile Infection. 2016 PLoS ONE pmid:26871580
Whiteside W et al. Altered Cholesterol Metabolism and Hypocholesterolemia in Patients with Single Ventricle following Fontan Palliation. 2016 J. Pediatr. pmid:26806364
Dayspring TD et al. Biomarkers of cholesterol homeostasis in a clinical laboratory database sample comprising 667,718 patients. 2015 Nov-Dec J Clin Lipidol pmid:26687702
Devane ML et al. Identifying avian sources of faecal contamination using sterol analysis. 2015 Environ Monit Assess pmid:26370196
Wang X et al. Plasma cholesterol-lowering activity of dietary dihydrocholesterol in hypercholesterolemia hamsters. 2015 Atherosclerosis pmid:26184696
Aoki K et al. Anagliptin decreases serum lathosterol level in patients with type 2 diabetes: a pilot study. 2015 Expert Opin Pharmacother pmid:26098722
Moraes EA et al. Cholestanol-loaded-cyclodextrin improves the quality of stallion spermatozoa after cryopreservation. 2015 Anim. Reprod. Sci. pmid:26005214
Luister A et al. Increased plant sterol deposition in vascular tissue characterizes patients with severe aortic stenosis and concomitant coronary artery disease. 2015 Steroids pmid:25814070
Benesch MG et al. A DSC and FTIR spectroscopic study of the effects of the epimeric coprostan-3-ols and coprostan-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogues. 2015 Chem. Phys. Lipids pmid:25804450
Kozanecka W et al. Synthesis, spectroscopy, theoretical and biological studies of new gramine-steroids salts and conjugates. 2015 Steroids pmid:25777948
Benesch MG et al. A DSC and FTIR spectroscopic study of the effects of the epimeric cholestan-3-ols and cholestan-3-one on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogs. 2015 Chem. Phys. Lipids pmid:25732198
Saeed T et al. Spatial assessment of the sewage contamination of Kuwait's marine areas. 2015 Mar. Pollut. Bull. pmid:25691339
Doukyu N and Nihei S Cholesterol oxidase with high catalytic activity from Pseudomonas aeruginosa: Screening, molecular genetic analysis, expression and characterization. 2015 J. Biosci. Bioeng. pmid:25573142
Carreira RS et al. Evidence of sewage input to inner shelf sediments in the NE coast of Brazil obtained by molecular markers distribution. 2015 Mar. Pollut. Bull. pmid:25467184
Bhatia C et al. Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. 2015 Chem. Biol. Interact. pmid:25526675
Bach D et al. Modulation of the kinetics of 3β-hydroxy-5-oxo-5,6-secocholestan-6-al/phosphatidylethanolamine Schiff base formation by cholesterol and cholesterol crystallization. 2015 Chem. Phys. Lipids pmid:25582951
Appadurai V et al. Apparent underdiagnosis of Cerebrotendinous Xanthomatosis revealed by analysis of ~60,000 human exomes. 2015 Mol. Genet. Metab. pmid:26643207
Lyons BP et al. Microbial water quality and sedimentary faecal sterols as markers of sewage contamination in Kuwait. 2015 Mar. Pollut. Bull. pmid:26228071
Matsuoka K et al. Competitive Solubilization of Cholesterol/Cholesteryl Oleate and Seven Species of Sterol/Stanol in Model Intestinal Solution System. 2015 J Oleo Sci pmid:26136176
Silbernagel G et al. Intestinal cholesterol absorption, treatment with atorvastatin, and cardiovascular risk in hemodialysis patients. 2015 J. Am. Coll. Cardiol. pmid:26022817
Lin X et al. Plasma biomarker of dietary phytosterol intake. 2015 PLoS ONE pmid:25668184
Mutanen A et al. Serum plant sterols, cholestanol, and cholesterol precursors associate with histological liver injury in pediatric onset intestinal failure. 2014 Am. J. Clin. Nutr. pmid:25099547
Harrault L et al. Are fecal stanols suitable to record and identify a pulse of human fecal contamination in short-term exposed shellfish? A microcosm study. 2014 Mar. Pollut. Bull. pmid:25455370
Tolosa I et al. Steroid markers to assess sewage and other sources of organic contaminants in surface sediments of Cienfuegos Bay, Cuba. 2014 Mar. Pollut. Bull. pmid:25127498
Mignarri A et al. A suspicion index for early diagnosis and treatment of cerebrotendinous xanthomatosis. 2014 J. Inherit. Metab. Dis. pmid:24442603
Varga VE et al. [Laboratory diagnosis of a rare congenital neurodegenerative disease: cerebrotendinous xanthomatosis]. 2014 Orv Hetil pmid:24836315
Yoshinaga T et al. Clinical and radiological findings of a cerebrotendinous xanthomatosis patient with a novel p.A335V mutation in the CYP27A1 gene. 2014 Intern. Med. pmid:25447658
Sistiaga A et al. The Neanderthal meal: a new perspective using faecal biomarkers. 2014 PLoS ONE pmid:24963925
Martins CC et al. An integrated evaluation of molecular marker indices and linear alkylbenzenes (LABs) to measure sewage input in a subtropical estuary (Babitonga Bay, Brazil). 2014 Environ. Pollut. pmid:24556228
Hallikainen M et al. Cholesterol metabolism and serum non-cholesterol sterols: summary of 13 plant stanol ester interventions. 2014 Lipids Health Dis pmid:24766766
Imperatore C et al. Phallusiasterols A and B: two new sulfated sterols from the Mediterranean tunicate Phallusia fumigata and their effects as modulators of the PXR receptor. 2014 Mar Drugs pmid:24705503
Mandrile G et al. Cerebrotendinous xanthomatosis: recurrence of the CYP27A1 mutation p.Arg479Cys in Sardinia. 2014 Neurol. Sci. pmid:24584636
von der Lühe B et al. Investigation of sterols as potential biomarkers for the detection of pig (S. s. domesticus) decomposition fluid in soils. 2013 Forensic Sci. Int. pmid:23583120
Björkhem I Cerebrotendinous xanthomatosis. 2013 Curr. Opin. Lipidol. pmid:23759795
de Medina P et al. Technical note: Hapten synthesis, antibody production and development of an enzyme-linked immunosorbent assay for detection of the natural steroidal alkaloid Dendrogenin A. 2013 Biochimie pmid:22709869
Ginanneschi F et al. Polyneuropathy in cerebrotendinous xanthomatosis and response to treatment with chenodeoxycholic acid. 2013 J. Neurol. pmid:22878431
Martini G et al. Long-term bone density evaluation in cerebrotendinous xanthomatosis: evidence of improvement after chenodeoxycholic acid treatment. 2013 Calcif. Tissue Int. pmid:23212544
Hope BK et al. A state-wide survey in Oregon (USA) of trace metals and organic chemicals in municipal effluent. 2012 Sci. Total Environ. pmid:22244355
Tansley G et al. Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. 2012 Curr Gerontol Geriatr Res pmid:22649448
Osman R et al. Chemometric application in identifying sources of organic contaminants in Langat river basin. 2012 Environ Monit Assess pmid:21494831
Jusakul A et al. Liver fluke-induced hepatic oxysterols stimulate DNA damage and apoptosis in cultured human cholangiocytes. 2012 Mutat. Res. pmid:22044627
Daughton CG Real-time estimation of small-area populations with human biomarkers in sewage. 2012 Sci. Total Environ. pmid:22137478
Nochioka K et al. Ezetimibe improves endothelial function and inhibits Rho-kinase activity associated with inhibition of cholesterol absorption in humans. 2012 Circ. J. pmid:22640986
Kurvinen A et al. Parenteral plant sterols and intestinal failure-associated liver disease in neonates. 2012 J. Pediatr. Gastroenterol. Nutr. pmid:22197940
Rogacev KS et al. Cholesterol synthesis, cholesterol absorption, and mortality in hemodialysis patients. 2012 Clin J Am Soc Nephrol pmid:22461539
Lahti M and Oikari A Vertical distribution of pharmaceuticals in lake sediments-citalopram as potential chemomarker. 2012 Environ. Toxicol. Chem. pmid:22639393
Suh S et al. Three siblings with Cerebrotendinous Xanthomatosis: a novel mutation in the CYP27A1 gene. 2012 Eur J Med Genet pmid:21958693
Koyama S et al. A case of cerebrotendinous xanthomatosis presenting with epilepsy as an initial symptom with a novel V413D mutation in the CYP27A1 gene. 2012 Clin Neurol Neurosurg pmid:22336472
Ale EC et al. Ordered-disordered domain coexistence in ternary lipid monolayers activates sphingomyelinase by clearing ceramide from the active phase. 2012 Biochim. Biophys. Acta pmid:22763279
Derrien M et al. Origin of fecal contamination in waters from contrasted areas: stanols as Microbial Source Tracking markers. 2012 Water Res. pmid:22673347
Ostrowska M et al. Cerebrotendinous xanthomatosis: a rare cause of spinocerebellar syndrome. 2011 Nov-Dec Neurol. Neurochir. Pol. pmid:22212991
Lupattelli G et al. Patterns of cholesterol metabolism: pathophysiological and therapeutic implications for dyslipidemias and the metabolic syndrome. 2011 Nutr Metab Cardiovasc Dis pmid:21855307
Yamamoto M et al. Structural requirements of virion-associated cholesterol for infectivity, buoyant density and apolipoprotein association of hepatitis C virus. 2011 J. Gen. Virol. pmid:21593275
Kurogi K et al. A comparative study of the sulfation of bile acids and a bile alcohol by the Zebra danio (Danio rerio) and human cytosolic sulfotransferases (SULTs). 2011 J. Steroid Biochem. Mol. Biol. pmid:21839837
Benesch MG et al. Sterol chemical configuration and conformation influence the thermotropic phase behaviour of dipalmitoylphosphatidylcholine mixtures containing 5β-cholestan-3β- and -3α-ol. 2011 Chem. Phys. Lipids pmid:21055393
Benesch MG et al. Sterol chemical configuration influences the thermotropic phase behaviour of dipalmitoylphosphatidylcholine bilayers containing 5α-cholestan-3β- and 3α-ol. 2011 Chem. Phys. Lipids pmid:21055394
Tomono S et al. Formation of cholesterol ozonolysis products in vitro and in vivo through a myeloperoxidase-dependent pathway. 2011 J. Lipid Res. pmid:20921334
Vrljic M et al. Post-translational modifications and lipid binding profile of insect cell-expressed full-length mammalian synaptotagmin 1. 2011 Biochemistry pmid:21928778
Inoue T et al. Inhibition of intestinal cholesterol absorption might explain cholesterol-lowering effect of telmisartan. 2011 J Clin Pharm Ther pmid:21198725
Pilo de la Fuente B et al. [Usefulness of cholestanol levels in the diagnosis and follow-up of patients with cerebrotendinous xanthomatosis]. 2011 Neurologia pmid:21345536
Vilela CG et al. Benthic foraminifera distribution in a tourist lagoon in Rio de Janeiro, Brazil: a response to anthropogenic impacts. 2011 Mar. Pollut. Bull. pmid:21871637
Monson DM et al. Cerebrotendinous xanthomatosis: a treatable disease with juvenile cataracts as a presenting sign. 2011 Arch. Ophthalmol. pmid:21825196
Wolff E et al. Cholesterol-absorber status modifies the LDL cholesterol-lowering effect of a Mediterranean-type diet in adults with moderate cardiovascular risk factors. 2011 J. Nutr. pmid:21865559
Rosa Ide A et al. Ultrastructural alterations induced by Δ(24(25))-sterol methyltransferase inhibitors on Trichomonas vaginalis. 2011 FEMS Microbiol. Lett. pmid:21175744
Cammarata A et al. Antifungal activity of 2α,3β-functionalized steroids stereoselectively increases with the addition of oligosaccharides. 2011 Bioorg. Med. Chem. Lett. pmid:22047693
Niesor EJ et al. Effect of dalcetrapib, a CETP modulator, on non-cholesterol sterol markers of cholesterol homeostasis in healthy subjects. 2011 Atherosclerosis pmid:21982411
Daly TA et al. The origin of cholesterol's condensing effect. 2011 Langmuir pmid:21319766
Gombos I et al. Membrane-lipid therapy in operation: the HSP co-inducer BGP-15 activates stress signal transduction pathways by remodeling plasma membrane rafts. 2011 PLoS ONE pmid:22174906
Hoenig MR et al. Markers of cholesterol absorption and synthesis predict the low-density lipoprotein cholesterol response to atorvastatin. 2010 J. Cardiovasc. Pharmacol. pmid:20625310
Lye HS et al. Removal of cholesterol by lactobacilli via incorporation and conversion to coprostanol. 2010 J. Dairy Sci. pmid:20338415
Okada K et al. Lipid-lowering effects of ezetimibe for hypercholesterolemic patients with and without type 2 diabetes mellitus. 2010 Endocr. J. pmid:20733267
Moliner-Martinez Y et al. Improving analysis of apolar organic compounds by the use of a capillary titania-based column: Application to the direct determination of faecal sterols cholesterol and coprostanol in wastewater samples. 2010 J Chromatogr A pmid:20546758
Hussain MA et al. Determination of fecal contamination indicator sterols in an Australian water supply system. 2010 Environ Monit Assess pmid:19421885
Hojo K et al. Determination of serum cholestanol by semi-micro high-performance liquid chromatography with electrochemical detection. 2010 Biomed. Chromatogr. pmid:19795364
Rosetti CM et al. Micron-scale phase segregation in lipid monolayers induced by myelin basic protein in the presence of a cholesterol analog. 2010 Biochim. Biophys. Acta pmid:19914203
Said J et al. Lipophile-conjugated sulfated oligosaccharides as novel microbicides against HIV-1. 2010 Antiviral Res. pmid:20307578
Montone RC et al. Distribution of sewage input in marine sediments around a maritime Antarctic research station indicated by molecular geochemical indicators. 2010 Sci. Total Environ. pmid:20656326
Gylling H et al. Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity: lessons from the METSIM Study. 2010 J. Lipid Res. pmid:20436182
Björkhem I and Hansson M Cerebrotendinous xanthomatosis: an inborn error in bile acid synthesis with defined mutations but still a challenge. 2010 Biochem. Biophys. Res. Commun. pmid:20494109
BÃ¥vner A et al. On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase. 2010 J. Lipid Res. pmid:20511491
Venkatesan MI et al. Trace organic contaminants and their sources in surface sediments of Santa Monica Bay, California, USA. 2010 Mar. Environ. Res. pmid:20129659
Moraes EA et al. Delivering cholesterol or cholestanol to bull sperm membranes improves cryosurvival. 2010 Anim. Reprod. Sci. pmid:19733986
Miettinen TA et al. Relation of non-cholesterol sterols to coronary risk factors and carotid intima-media thickness: the Cardiovascular Risk in Young Finns Study. 2010 Atherosclerosis pmid:19963215
Pakarinen MP et al. Surrogate markers of cholesterol metabolism in children with native liver after successful portoenterostomy for biliary atresia. 2010 J. Pediatr. Surg. pmid:20713216