Dihydrocholesterol

Dihydrocholesterol is a lipid of Sterol Lipids (ST) class. Dihydrocholesterol is associated with abnormalities such as Exanthema, Morphologically altered structure, protrusion, Dehydration and Xanthoma. The involved functions are known as Regulation, Biochemical Pathway, Methylation, Metabolic Inhibition and Biosynthetic Pathways. Dihydrocholesterol often locates in envelope, Mitochondria, Lipid Bilayers, Host Cell and Membrane. The associated genes with Dihydrocholesterol are GRAP2 gene, PTP4A2 gene, HSD3B7 gene, MBD2 gene and IGF2BP3 gene. The related lipids are Sterols, Cardiolipins, Pregnanes, 7-hydroxy-4-cholesten-3-one and Hydroxycholesterols. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Dihydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Dihydrocholesterol?

Dihydrocholesterol is suspected in Xanthoma, Xanthomatosis, Cerebrotendinous, Coronary heart disease, Exanthema, Morphologically altered structure, Dehydration and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Dihydrocholesterol

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Cataract D002386 34 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Alcoholism D000437 27 associated lipids
Brain Diseases, Metabolic D001928 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Xanthomatosis D014973 17 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 9

PubChem Associated disorders and diseases

What pathways are associated with Dihydrocholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Dihydrocholesterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Dihydrocholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Dihydrocholesterol?

Related references are published most in these journals:

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What genes are associated with Dihydrocholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Dihydrocholesterol?

Mouse Model

Mouse Model are used in the study 'On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase.' (BÃ¥vner A et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Dihydrocholesterol

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Authors Title Published Journal PubMed Link
pmid:
Inoue K et al. Cholestanol induces apoptosis of cerebellar neuronal cells. 1999 Biochem. Biophys. Res. Commun. pmid:10066446
Fadden K et al. Steroid metabolism along the gastrointestinal tract of the cannulated pig. 1999 Eur. J. Cancer Prev. pmid:10091041
Gylling H et al. Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population. 1999 J. Lipid Res. pmid:10191283
Uchida K et al. Transformation of bile acids and sterols by clostridia (fusiform bacteria) in Wistar rats. 1999 Lipids pmid:10230721
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Radhakrishnan A and McConnell HM Condensed complexes of cholesterol and phospholipids. 1999 Biophys. J. pmid:10465761
Fernandes MB et al. Sedimentary 4-desmethyl sterols and n-alkanols in an eutrophic urban estuary, Capibaribe River, Brazil. 1999 Sci. Total Environ. pmid:10466230
Larking PW Cancer and low levels of plasma cholesterol: the relevance of cholesterol precursors and products to incidence of cancer. 1999 Prev Med pmid:10564630
Liendo A et al. Sterol composition and biosynthesis in Trypanosoma cruzi amastigotes. 1999 Mol. Biochem. Parasitol. pmid:10589983
Radhakrishnan A and McConnell HM Electric field effect on cholesterol-phospholipid complexes. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10655486
Inoue K et al. Cholestanol induces apoptosis of corneal endothelial and lens epithelial cells. 2000 Invest. Ophthalmol. Vis. Sci. pmid:10752932
Verrips A et al. Presence of diarrhea and absence of tendon xanthomas in patients with cerebrotendinous xanthomatosis. 2000 Arch. Neurol. pmid:10768627
Miettinen TA et al. Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol. 2000 Arterioscler. Thromb. Vasc. Biol. pmid:10807752
Collinder E et al. Six intestinal microflora-associated characteristics in sport horses. 2000 Equine Vet. J. pmid:10836477
Björkhem I and Leitersdorf E Sterol 27-hydroxylase deficiency: a rare cause of xanthomas in normocholesterolemic humans. 2000 Trends Endocrinol. Metab. pmid:10856919
Halperin G et al. A new method for determination of serum cholestanol by high-performance liquid chromatography with ultraviolet detection. 2000 J. Chromatogr. B Biomed. Sci. Appl. pmid:10901139
Friedman M et al. Lowering of plasma LDL cholesterol in hamsters by the tomato glycoalkaloid tomatine. 2000 Food Chem. Toxicol. pmid:10942315
Collinder E et al. Influence of bacitracin on microbial functions in the gastrointestinal tract of horses. 2000 Equine Vet. J. pmid:10952385
Fleck JD et al. Neuroimages: cerebrotendinous xanthomatosis. 2000 Neurology pmid:10953208
Watne AL and Core SK Fecal steroids in polyposis coli and ileorectostomy patients. 1975 J. Surg. Res. pmid:1100901
Kraaipoel RJ et al. Incorporation of H2 18O into 20alpha, 22R-di-OH cholesterol: evidence for an epoxide-diol pathway in the adrenocortical cholesterol side-chain cleavage mechanism. 1975 FEBS Lett. pmid:1102334
Snider BB et al. Letter: Removal of the steroid side chain using remote oxidation. Conversion of 3beta-cholestranol to androsterone acetate. 1975 J. Am. Chem. Soc. pmid:1102590
Radhakrishnan A et al. Condensed complexes, rafts, and the chemical activity of cholesterol in membranes. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:11050164
Böttcher MF et al. Microflora-associated characteristics in faeces from allergic and nonallergic infants. 2000 Clin. Exp. Allergy pmid:11069568
Yan JL et al. Microbial transformation of 3-hydroxy-5,6-cyclopropanocholestanes--an alternative route to 6-methylsteroids. 2000 Steroids pmid:11077084
Eganhouse RP and Sherblom PM Anthropogenic organic contaminants in the effluent of a combined sewer overflow: impact on Boston Harbor. 2001 Mar. Environ. Res. pmid:11125703
Burnett JR et al. Clinical and biochemical features, molecular diagnosis and long-term management of a case of cerebrotendinous xanthomatosis. 2001 Clin. Chim. Acta pmid:11282095
Inoue K et al. [Cerebrotendinous xanthomatosis]. 2001 Nippon Rinsho pmid:11347094
Quilliot D et al. Phytosterols have an unfavourable effect on bacterial activity and no evident protective effect on colon carcinogenesis. 2001 Eur. J. Cancer Prev. pmid:11432710
Lin DS and Connor WE Fecal steroids of the coprolite of a Greenland Eskimo mummy, AD 1475: a clue to dietary sterol intake. 2001 Am. J. Clin. Nutr. pmid:11451716
Sugama S et al. Frontal lobe dementia with abnormal cholesterol metabolism and heterozygous mutation in sterol 27-hydroxylase gene (CYP27). 2001 J. Inherit. Metab. Dis. pmid:11486904
Mondelli M et al. Cerebrotendinous xanthomatosis: 11-year treatment with chenodeoxycholic acid in five patients. An electrophysiological study. 2001 J. Neurol. Sci. pmid:11574103
Gagné F et al. Evidence of coprostanol estrogenicity to the freshwater mussel Elliptio complanata. 2001 Environ. Pollut. pmid:11586778
Brämswig S et al. Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:11788421
Rodrigues JC et al. Ultrastructural and biochemical alterations induced by 22,26-azasterol, a delta(24(25))-sterol methyltransferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis. 2002 Antimicrob. Agents Chemother. pmid:11796362
Gylling H and Miettinen TA Baseline intestinal absorption and synthesis of cholesterol regulate its response to hypolipidaemic treatments in coronary patients. 2002 Atherosclerosis pmid:11849674
Bull ID et al. The origin of faeces by means of biomarker detection. 2002 Environ Int pmid:11934114
Moghadasian MH et al. Cerebrotendinous xanthomatosis: a rare disease with diverse manifestations. 2002 Arch. Neurol. pmid:11939886
Petucci C et al. Differentiation of stereoisomeric steroids by reactions with phosphenium ions. 2002 J. Am. Soc. Mass Spectrom. pmid:11951974
Lamon-Fava S et al. Two novel mutations in the sterol 27-hydroxylase gene causing cerebrotendinous xanthomatosis. 2002 Clin. Genet. pmid:12000359
Simonen PP et al. Body weight modulates cholesterol metabolism in non-insulin dependent type 2 diabetics. 2002 Obes. Res. pmid:12006631
Nakajima N et al. Biosynthesis of cholestanol in higher plants. 2002 Phytochemistry pmid:12031446
Okonogi TM et al. Two fatty acids can replace one phospholipid in condensed complexes with cholesterol. 2002 Biochim. Biophys. Acta pmid:12100988
von Bahr S et al. Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1). 2002 Arterioscler. Thromb. Vasc. Biol. pmid:12117727
Miettinen TA and Gylling H Ineffective decrease of serum cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients. 2002 Atherosclerosis pmid:12119203
Cruz JC et al. Synthesis and biochemical properties of a new photoactivatable cholesterol analog 7,7-azocholestanol and its linoleate ester in Chinese hamster ovary cell lines. 2002 J. Lipid Res. pmid:12177179
Radhakrishnan A and McConnell HM Critical points in charged membranes containing cholesterol. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12368466
Peng X et al. Spatial and temporal trend of sewage pollution indicated by coprostanol in Macao Estuary, southern China. 2002 Mar. Pollut. Bull. pmid:12398399