Dihydrocholesterol

Dihydrocholesterol is a lipid of Sterol Lipids (ST) class. Dihydrocholesterol is associated with abnormalities such as Exanthema, Morphologically altered structure, protrusion, Dehydration and Xanthoma. The involved functions are known as Regulation, Biochemical Pathway, Methylation, Metabolic Inhibition and Biosynthetic Pathways. Dihydrocholesterol often locates in envelope, Mitochondria, Lipid Bilayers, Host Cell and Membrane. The associated genes with Dihydrocholesterol are GRAP2 gene, PTP4A2 gene, HSD3B7 gene, MBD2 gene and IGF2BP3 gene. The related lipids are Sterols, Cardiolipins, Pregnanes, 7-hydroxy-4-cholesten-3-one and Hydroxycholesterols. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Dihydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Dihydrocholesterol?

Dihydrocholesterol is suspected in Xanthoma, Xanthomatosis, Cerebrotendinous, Coronary heart disease, Exanthema, Morphologically altered structure, Dehydration and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Dihydrocholesterol

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Cataract D002386 34 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Alcoholism D000437 27 associated lipids
Brain Diseases, Metabolic D001928 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Xanthomatosis D014973 17 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 9

PubChem Associated disorders and diseases

What pathways are associated with Dihydrocholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Dihydrocholesterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Dihydrocholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Dihydrocholesterol?

Related references are published most in these journals:

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What genes are associated with Dihydrocholesterol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Dihydrocholesterol?

Mouse Model

Mouse Model are used in the study 'On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase.' (BÃ¥vner A et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Dihydrocholesterol

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Authors Title Published Journal PubMed Link
Lamiquiz-Moneo I et al. ABCG5/G8 gene is associated with hypercholesterolemias without mutation in candidate genes and noncholesterol sterols. J Clin Lipidol pmid:29066094
pmid:
SIPERSTEIN MD et al. Prevention of plasma cholesterol elevation and atheromatosis in the cholesterol-fed bird by the administration of dihydrocholesterol. 1953 Circulation pmid:13019916
ROSENFELD RS et al. The transformation of cholesterol to coprostanol. 1954 J. Biol. Chem. pmid:13211667
BEHER WT and ANTHONY WL Prevention of the cholesterol type of fatty livers in mice by dietary dihydrocholesterol. 1954 J. Nutr. pmid:13163738
ROSENMAN RH et al. The effect of dihydrocholesterol on the absorption of cholesterol by the rat. 1954 Circ. Res. pmid:13116393
IVY AC et al. Absorption of dihydrocholesterol and soya sterols by the rat's intestine. 1955 Am. J. Physiol. pmid:13268640
GALLAGHER TF et al. The transformation of cholesterol-3d to coprostanol-d. Location of deuterium in coprostanol. 1956 J. Biol. Chem. pmid:13367005
SNOG-KJAER A et al. Conversion of cholesterol into coprosterol by bacteria in vitro. 1956 J. Gen. Microbiol. pmid:13319631
MOSBACH EH and BEVANS M Formation of gall stones in rabbits fed 3beta-cholestanol. 1956 Arch. Biochem. Biophys. pmid:13341064
COLEMAN DL et al. Intestinal sterols. II. Determination of coprostanol and certain related sterols. 1956 Arch. Biochem. Biophys. pmid:13292920
BEHER WT et al. Effect of dihydrocholesterol and beta-sitosterol on cholesterol atherosclerosis in rabbits. 1957 Circ. Res. pmid:13414097
WELLS WW Coprostanol formation. I. The effect of sodium taurocholate and Tween 80 on the sterol composition of rat feces. 1957 Arch. Biochem. Biophys. pmid:13395541
CHAIKOFF IL et al. Metabolism of cholestanol. I. Fate of cholestanol-4-C14 in the rat. II. Metabolic interrelations of cholestanol, epicholesterol, and delta4-cholestenone. 1957 J. Biol. Chem. pmid:13398433
WELLS WW and COOPER SB Coprostanol formation. II. The opposing action of dietary lactose and calcium on cholesterol absorption. 1958 Arch. Biochem. Biophys. pmid:13534706
PRANGE I et al. Bacterial conversion of cholesterol into coprostanol independent of cerebrosides in the medium. 1958 Acta Pathol Microbiol Scand pmid:13508244
CHAPMAN DD and CHAIKOFF IL The manner of absorption of 3-beta-cholestanol and delta 4-cholestenone by the rat. 1959 J. Biol. Chem. pmid:13630893
MOSBACH EH and BEVANS M Early pathologic and biochemical changes in rabbits fed dihydrocholesterol. 1960 Am. J. Pathol. pmid:13772987
GERSON T The determination of cholesterol and coprosterol in faecal lipids. 1960 Biochem. J. pmid:13704757
WELLS WW et al. Lactose diets and cholesterol metabolism. I. Cholesterol absorption, coprostanol formation and bile acid excretion in the rat. 1960 J. Nutr. pmid:13784265
SETTY CS and IVY AC Intestinal absorption of coprostanol (coprosterol) in the rat. 1960 Am. J. Physiol. pmid:13750401
VAHOUNY GV et al. Comparison of lymphatic absorption of dihydrocholesterol and cholesterol in the rat. 1960 Arch. Biochem. Biophys. pmid:13840683
SIERACKI JC et al. Experimental aortic atherosclerosis in rabbits following the ingestion of dihydrocholesterol. 1960 Angiology pmid:14446526
SMITH PF Fate of ergosterol and cholestanol in pleuro-pneumonia-like organisms. 1962 J. Bacteriol. pmid:13989541
MOSBACH EH et al. A new method for the determination of dihydrocholesterol in tissues. 1963 Anal. Biochem. pmid:13936102
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CLAYTON RB and EDWARDS AM Conversion of 5-alpha-cholestan-3-beta-ol to delta-7-5-alpha-cholesten-3-beta-ol in cockroaches. 1963 J. Biol. Chem. pmid:14021649
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KURODA M et al. A DERIVATIVE ISOTOPE DILUTION METHOD FOR DETERMINATION OF 5-ALPHA-CHOLESTAN-3-BETA-OL: ITS APPLICATION TO ADRENAL TISSUE. 1964 Anal. Biochem. pmid:14246124
SHEFER S et al. BIOSYNTHESIS OF 5-ALPHA-CHOLESTAN-3-BETA-OL IN THE RABBIT AND GUINEA PIG. 1964 J. Biol. Chem. pmid:14213342
HOFMANN AF and MOSBACH EH IDENTIFICATION OF ALLODEOXYCHOLIC ACID AS THE MAJOR COMPONENT OF GALLSTONES INDUCED IN THE RABBIT BY 5-ALPHA-CHOLESTAN-3-BETA-OL. 1964 J. Biol. Chem. pmid:14216431
ROSENFELD RS THE ISOLATION OF COPROSTANOL FROM STEROL ESTERS OF HUMAN FECES. 1964 Arch. Biochem. Biophys. pmid:14244675
VAN DER LINDEN W ON GALLSTONE FORMATION IN RABBITS INDUCED BY DIHYDROCHOLESTEROL. 2. INFLUENCE OF OLIVE OIL IN THE DIET. 1965 Acta Chir Scand pmid:14296589
SHEFER S et al. BIOSYNTHESIS OF 5-ALPHA-CHOLESTAN-3-BETA-OL IN RAT AND GUINEA PIG LIVER IN VITRO. 1965 J. Lipid Res. pmid:14280469
Mosbach EH et al. Prevention of cholestanol-induced cholelithiasis by neomycin. 1965 Nature pmid:5331257
Lindelöf G and Van der Linden W The role of stasis in experimental gallstone formation. 1965 Acta Chir Scand pmid:5324759
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Takiguchi H et al. Suppression of cholesterol synthesis in rat liver by dihydrocholesterol administration. 1966 J. Biochem. pmid:4860849
Rosenfeld RS et al. Conversion of cholesterol injected into man to cholestanol via a 3-ketonic intermediate. 1967 J. Lipid Res. pmid:14564700
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Rothblat GH and Kritchevsky D The excretion of free and ester cholesterol by tissue culture cells: studies with L5178Y and L-cells. 1967 Biochim. Biophys. Acta pmid:4863609
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