Dihydrocholesterol is a lipid of Sterol Lipids (ST) class. Dihydrocholesterol is associated with abnormalities such as Exanthema, Morphologically altered structure, protrusion, Dehydration and Xanthoma. The involved functions are known as Regulation, Biochemical Pathway, Methylation, Metabolic Inhibition and Biosynthetic Pathways. Dihydrocholesterol often locates in envelope, Mitochondria, Lipid Bilayers, Host Cell and Membrane. The associated genes with Dihydrocholesterol are GRAP2 gene, PTP4A2 gene, HSD3B7 gene, MBD2 gene and IGF2BP3 gene. The related lipids are Sterols, Cardiolipins, Pregnanes, 7-hydroxy-4-cholesten-3-one and Hydroxycholesterols. The related experimental models are Mouse Model.
To understand associated biological information of Dihydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Dihydrocholesterol is suspected in Xanthoma, Xanthomatosis, Cerebrotendinous, Coronary heart disease, Exanthema, Morphologically altered structure, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Dihydrocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase.' (BÃ¥vner A et al., 2010).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ha TB and Djerassi C | Minor and trace sterols in marine invertebrates. 62. Novel coprostanols with unusual side chains from the marine sponge Calyx nicaeensis. | 1989 Mar-May | Steroids | pmid:2508274 |
| Seidel SB et al. | Minor and trace sterols from marine invertebrates 56. Novel coprostanols from the marine sponge Petrosia ficiformis. | 1986 | Steroids | pmid:3101232 |
| Yan JL et al. | Microbial transformation of 3-hydroxy-5,6-cyclopropanocholestanes--an alternative route to 6-methylsteroids. | 2000 | Steroids | pmid:11077084 |
| Lin HS et al. | Synthesis of 4 alpha-(2-propenyl)-5,6-secocholestan-3 alpha-ol, a novel B-ring seco analog of the hypocholesterolemic agent 4 alpha-(2-propenyl)-5 alpha-cholestan-3 alpha-ol. | 1998 | Steroids | pmid:9589554 |
| Kozanecka W et al. | Synthesis, spectroscopy, theoretical and biological studies of new gramine-steroids salts and conjugates. | 2015 | Steroids | pmid:25777948 |
| Garside D et al. | Synthesis of hydroxylated steroid hormones via conjugate addition of a silyl-cuprate reagent. | 1994 | Steroids | pmid:7900169 |
| Garraffo HM and Gros EG | Biosynthesis of bufadienolides in toads. VI. Experiments with [1,2-3H]cholesterol, [21-14C]coprostanol, and 5 beta-[21-14 C]pregnanolone in the toad Bufo arenarum. | 1986 Sep-Oct | Steroids | pmid:3127947 |
| Makarieva TN et al. | Biosynthetic studies of marine lipids. 42. Biosynthesis of steroid and triterpenoid metabolites in the sea cucumber Eupentacta fraudatrix. | 1993 | Steroids | pmid:8273112 |
| Janssen G and Parmentier G | A further study of the bile acids in infants with coprostanic acidemia. | 1981 | Steroids | pmid:6784283 |
| Tam Ha TB et al. | Minor sterols of marine invertebrates 37. Isolation of novel coprostanols and 4 alpha-methyl sterols from the tunicate Ascidia nigra. | 1982 | Steroids | pmid:6820582 |