Dihydrocholesterol

Dihydrocholesterol is a lipid of Sterol Lipids (ST) class. Dihydrocholesterol is associated with abnormalities such as Exanthema, Morphologically altered structure, protrusion, Dehydration and Xanthoma. The involved functions are known as Regulation, Biochemical Pathway, Methylation, Metabolic Inhibition and Biosynthetic Pathways. Dihydrocholesterol often locates in envelope, Mitochondria, Lipid Bilayers, Host Cell and Membrane. The associated genes with Dihydrocholesterol are GRAP2 gene, PTP4A2 gene, HSD3B7 gene, MBD2 gene and IGF2BP3 gene. The related lipids are Sterols, Cardiolipins, Pregnanes, 7-hydroxy-4-cholesten-3-one and Hydroxycholesterols. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Dihydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Dihydrocholesterol?

Dihydrocholesterol is suspected in Xanthoma, Xanthomatosis, Cerebrotendinous, Coronary heart disease, Exanthema, Morphologically altered structure, Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Dihydrocholesterol

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Cataract D002386 34 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Alcoholism D000437 27 associated lipids
Brain Diseases, Metabolic D001928 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Xanthomatosis D014973 17 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 9

PubChem Associated disorders and diseases

What pathways are associated with Dihydrocholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Dihydrocholesterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Dihydrocholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Dihydrocholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Dihydrocholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Dihydrocholesterol?

Mouse Model

Mouse Model are used in the study 'On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase.' (BÃ¥vner A et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Dihydrocholesterol

Download all related citations
Per page 10 20 50 100 | Total 471
Authors Title Published Journal PubMed Link
Ito S et al. Combined treatment with LDL-apheresis, chenodeoxycholic acid and HMG-CoA reductase inhibitor for cerebrotendinous xanthomatosis. 2003 J. Neurol. Sci. pmid:14607320
Addona GH et al. Low chemical specificity of the nicotinic acetylcholine receptor sterol activation site. 2003 Biochim. Biophys. Acta pmid:12543379
Seyama Y Cholestanol metabolism, molecular pathology, and nutritional implications. 2003 J Med Food pmid:14585188
Yu L et al. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12444248
Rodrigues JC et al. Ultrastructural and biochemical alterations induced by 22,26-azasterol, a delta(24(25))-sterol methyltransferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis. 2002 Antimicrob. Agents Chemother. pmid:11796362
Petucci C et al. Differentiation of stereoisomeric steroids by reactions with phosphenium ions. 2002 J. Am. Soc. Mass Spectrom. pmid:11951974
Bull ID et al. The origin of faeces by means of biomarker detection. 2002 Environ Int pmid:11934114
Moghadasian MH et al. Cerebrotendinous xanthomatosis: a rare disease with diverse manifestations. 2002 Arch. Neurol. pmid:11939886
Peng X et al. Spatial and temporal trend of sewage pollution indicated by coprostanol in Macao Estuary, southern China. 2002 Mar. Pollut. Bull. pmid:12398399
Okonogi TM et al. Two fatty acids can replace one phospholipid in condensed complexes with cholesterol. 2002 Biochim. Biophys. Acta pmid:12100988
Campdelacreu J et al. [Cerebrotendinous xanthomatosis without tendinous xanthomas: presentation of two cases]. 2002 Neurologia pmid:12487962
Isobe KO et al. Quantitative application of fecal sterols using gas chromatography-mass spectrometry to investigate fecal pollution in tropical waters: western Malaysia and Mekong Delta, Vietnam. 2002 Environ. Sci. Technol. pmid:12433157
Gylling H and Miettinen TA Baseline intestinal absorption and synthesis of cholesterol regulate its response to hypolipidaemic treatments in coronary patients. 2002 Atherosclerosis pmid:11849674
Miettinen TA and Gylling H Ineffective decrease of serum cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients. 2002 Atherosclerosis pmid:12119203
Simonen PP et al. Body weight modulates cholesterol metabolism in non-insulin dependent type 2 diabetics. 2002 Obes. Res. pmid:12006631
Radhakrishnan A and McConnell HM Critical points in charged membranes containing cholesterol. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12368466
Veatch SL and Keller SL Organization in lipid membranes containing cholesterol. 2002 Phys. Rev. Lett. pmid:12484857
Brämswig S et al. Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:11788421
Nakajima N et al. Biosynthesis of cholestanol in higher plants. 2002 Phytochemistry pmid:12031446
Heller R et al. [Cerebrotendinous xanthomatosis, a treatable metabolic disorder]. 2002 Nervenarzt pmid:12486565
Cruz JC et al. Synthesis and biochemical properties of a new photoactivatable cholesterol analog 7,7-azocholestanol and its linoleate ester in Chinese hamster ovary cell lines. 2002 J. Lipid Res. pmid:12177179
Lamon-Fava S et al. Two novel mutations in the sterol 27-hydroxylase gene causing cerebrotendinous xanthomatosis. 2002 Clin. Genet. pmid:12000359
von Bahr S et al. Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1). 2002 Arterioscler. Thromb. Vasc. Biol. pmid:12117727
Mondelli M et al. Cerebrotendinous xanthomatosis: 11-year treatment with chenodeoxycholic acid in five patients. An electrophysiological study. 2001 J. Neurol. Sci. pmid:11574103
Gagné F et al. Evidence of coprostanol estrogenicity to the freshwater mussel Elliptio complanata. 2001 Environ. Pollut. pmid:11586778
Inoue K et al. [Cerebrotendinous xanthomatosis]. 2001 Nippon Rinsho pmid:11347094
Eganhouse RP and Sherblom PM Anthropogenic organic contaminants in the effluent of a combined sewer overflow: impact on Boston Harbor. 2001 Mar. Environ. Res. pmid:11125703
Lin DS and Connor WE Fecal steroids of the coprolite of a Greenland Eskimo mummy, AD 1475: a clue to dietary sterol intake. 2001 Am. J. Clin. Nutr. pmid:11451716
Burnett JR et al. Clinical and biochemical features, molecular diagnosis and long-term management of a case of cerebrotendinous xanthomatosis. 2001 Clin. Chim. Acta pmid:11282095
Sugama S et al. Frontal lobe dementia with abnormal cholesterol metabolism and heterozygous mutation in sterol 27-hydroxylase gene (CYP27). 2001 J. Inherit. Metab. Dis. pmid:11486904
Quilliot D et al. Phytosterols have an unfavourable effect on bacterial activity and no evident protective effect on colon carcinogenesis. 2001 Eur. J. Cancer Prev. pmid:11432710
Inoue K et al. Cholestanol induces apoptosis of corneal endothelial and lens epithelial cells. 2000 Invest. Ophthalmol. Vis. Sci. pmid:10752932
Verrips A et al. Presence of diarrhea and absence of tendon xanthomas in patients with cerebrotendinous xanthomatosis. 2000 Arch. Neurol. pmid:10768627
Yan JL et al. Microbial transformation of 3-hydroxy-5,6-cyclopropanocholestanes--an alternative route to 6-methylsteroids. 2000 Steroids pmid:11077084
Friedman M et al. Lowering of plasma LDL cholesterol in hamsters by the tomato glycoalkaloid tomatine. 2000 Food Chem. Toxicol. pmid:10942315
Fleck JD et al. Neuroimages: cerebrotendinous xanthomatosis. 2000 Neurology pmid:10953208
Halperin G et al. A new method for determination of serum cholestanol by high-performance liquid chromatography with ultraviolet detection. 2000 J. Chromatogr. B Biomed. Sci. Appl. pmid:10901139
Collinder E et al. Influence of bacitracin on microbial functions in the gastrointestinal tract of horses. 2000 Equine Vet. J. pmid:10952385
Miettinen TA et al. Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol. 2000 Arterioscler. Thromb. Vasc. Biol. pmid:10807752
Radhakrishnan A and McConnell HM Electric field effect on cholesterol-phospholipid complexes. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10655486
Björkhem I and Leitersdorf E Sterol 27-hydroxylase deficiency: a rare cause of xanthomas in normocholesterolemic humans. 2000 Trends Endocrinol. Metab. pmid:10856919
Radhakrishnan A et al. Condensed complexes, rafts, and the chemical activity of cholesterol in membranes. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:11050164
Collinder E et al. Six intestinal microflora-associated characteristics in sport horses. 2000 Equine Vet. J. pmid:10836477
Böttcher MF et al. Microflora-associated characteristics in faeces from allergic and nonallergic infants. 2000 Clin. Exp. Allergy pmid:11069568
Fernandes MB et al. Sedimentary 4-desmethyl sterols and n-alkanols in an eutrophic urban estuary, Capibaribe River, Brazil. 1999 Sci. Total Environ. pmid:10466230
Fadden K et al. Steroid metabolism along the gastrointestinal tract of the cannulated pig. 1999 Eur. J. Cancer Prev. pmid:10091041
Larking PW Cancer and low levels of plasma cholesterol: the relevance of cholesterol precursors and products to incidence of cancer. 1999 Prev Med pmid:10564630
Batta AK et al. Highly simplified method for gas-liquid chromatographic quantitation of bile acids and sterols in human stool. 1999 J. Lipid Res. pmid:10357847
Gylling H et al. Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population. 1999 J. Lipid Res. pmid:10191283
Panda SK et al. Correlation of neomycin, faecal neutral and acid sterols with colon carcinogenesis in rats. 1999 Br. J. Cancer pmid:10376962
Radhakrishnan A and McConnell HM Condensed complexes of cholesterol and phospholipids. 1999 Biophys. J. pmid:10465761
Liendo A et al. Sterol composition and biosynthesis in Trypanosoma cruzi amastigotes. 1999 Mol. Biochem. Parasitol. pmid:10589983
Uchida K et al. Transformation of bile acids and sterols by clostridia (fusiform bacteria) in Wistar rats. 1999 Lipids pmid:10230721
Inoue K et al. Cholestanol induces apoptosis of cerebellar neuronal cells. 1999 Biochem. Biophys. Res. Commun. pmid:10066446
Gylling H et al. Oral guar gum treatment of intrahepatic cholestasis and pruritus in pregnant women: effects on serum cholestanol and other non-cholesterol sterols. 1998 Eur. J. Clin. Invest. pmid:9650008
Lin HS et al. Synthesis of 4 alpha-(2-propenyl)-5,6-secocholestan-3 alpha-ol, a novel B-ring seco analog of the hypocholesterolemic agent 4 alpha-(2-propenyl)-5 alpha-cholestan-3 alpha-ol. 1998 Steroids pmid:9589554
Kawabata M et al. Pulmonary manifestations in cerebrotendinous xanthomatosis. 1998 Intern. Med. pmid:9868952
Vanhoof K and De Schrijver R The influence of enzyme-resistant starch on cholesterol metabolism in rats fed on a conventional diet. 1998 Br. J. Nutr. pmid:9828761
Srikumar TS et al. Analysis of fecal bile acids and neutral steroids using gas-liquid chromatography. 1998 Ann. Nutr. Metab. pmid:9745109
Miettinen TA et al. Baseline serum cholestanol as predictor of recurrent coronary events in subgroup of Scandinavian simvastatin survival study. Finnish 4S Investigators. 1998 BMJ pmid:9552949
Börjesson E et al. New method for determination of fecal sterols in urine using non-chlorinated solvents. 1998 J. Chromatogr. B Biomed. Sci. Appl. pmid:9746261
Wallis EJ et al. Cholestanol and survival with simvastatin. More data are needed. 1998 BMJ pmid:9794879
Reddy S et al. Faecal pH, bile acid and sterol concentrations in premenopausal Indian and white vegetarians compared with white omnivores. 1998 Br. J. Nutr. pmid:9771336
Kinoshita M and Teramoto T [Cerebrotendinous xanthomatosis (CTX)]. 1998 Ryoikibetsu Shokogun Shirizu pmid:9645021
Contreras LM et al. Altered lipid composition and enzyme activities of plasma membranes from Trypanosoma (Schizotrypanum) cruzi epimastigotes grown in the presence of sterol biosynthesis inhibitors. 1997 Biochem. Pharmacol. pmid:9113089
Morita T et al. Cholesterol-lowering effects of soybean, potato and rice proteins depend on their low methionine contents in rats fed a cholesterol-free purified diet. 1997 J. Nutr. pmid:9082032
Adachi J et al. Epicoprostanol found in adipocere from five human autopsies. 1997 Lipids pmid:9397400
Hagen JP and McConnell HM Liquid-liquid immiscibility in lipid monolayers. 1997 Biochim. Biophys. Acta pmid:9370239
Urbina JA et al. Inhibitors of delta24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii. 1997 Antimicrob. Agents Chemother. pmid:9210660
Gerasimov OV et al. Acid-catalyzed plasmenylcholine hydrolysis and its effect on bilayer permeability: a quantitative study. 1997 Biochim. Biophys. Acta pmid:9092707
Urbina JA et al. Antiproliferative effects of delta 24(25) sterol methyl transferase inhibitors on Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies. 1996 Jul-Aug Chemotherapy pmid:8804798
Wilson WK et al. Analysis of unsaturated C27 sterols by nuclear magnetic resonance spectroscopy. 1996 J. Lipid Res. pmid:8827525
Li L et al. Effect of orally administered Eubacterium coprostanoligenes ATCC 51222 on plasma cholesterol concentration in laying hens. 1996 Poult. Sci. pmid:8737839
Gylling H et al. The metabolism of cholestanol in primary biliary cirrhosis. 1996 J. Hepatol. pmid:8738731
Hagen JP and McConnell HM Critical pressures in multicomponent lipid monolayers. 1996 Biochim. Biophys. Acta pmid:8639690
Okuyama E et al. A novel mutation in the cytochrome P450(27) (CYP27) gene caused cerebrotendinous xanthomatosis in a Japanese family. 1996 J. Lipid Res. pmid:8728324
Hakala K et al. Serum cholesterol, cholesterol precursors and plant sterols in different inflammatory bowel diseases. 1996 Digestion pmid:8786005
Ren D et al. Mechanism of cholesterol reduction to coprostanol by Eubacterium coprostanoligenes ATCC 51222. 1996 Steroids pmid:8789734
van Heijst AF et al. Chronic diarrhoea as a dominating symptom in two children with cerebrotendinous xanthomatosis. 1996 Acta Paediatr. pmid:8863874
Miettinen TA et al. Serum cholestanol, cholesterol precursors, and plant sterols during placebo-controlled treatment of primary biliary cirrhosis with ursodeoxycholic acid or colchicine. 1995 Hepatology pmid:7737632
Vanhanen HT and Miettinen TA Cholesterol absorption and synthesis during pravastatin, gemfibrozil and their combination. 1995 Atherosclerosis pmid:7661873
Li L et al. Hypocholesterolemic effect of Eubacterium coprostanoligenes ATCC 51222 in rabbits. 1995 Lett. Appl. Microbiol. pmid:7766068
Lau WF et al. Potentiation of beta-adrenoceptor agonist mediated-lipolysis by cholesterol-derived oxysterols. 1995 Biochem. Mol. Biol. Int. pmid:7492973
Lee KY and McConnell HM Effect of electric field gradients on lipid monolayer membranes. 1995 Biophys. J. pmid:7612817
Kim KS et al. Identification of new mutations in sterol 27-hydroxylase gene in Japanese patients with cerebrotendinous xanthomatosis (CTX). 1994 J. Lipid Res. pmid:7915755
Kuriyama M et al. Treatment of cerebrotendinous xanthomatosis: effects of chenodeoxycholic acid, pravastatin, and combined use. 1994 J. Neurol. Sci. pmid:7964884
Salen G et al. Inverse relationship between plasma cholestanol concentrations and bile acid synthesis in sitosterolemia. 1994 J. Lipid Res. pmid:7852865
Garside D et al. Synthesis of hydroxylated steroid hormones via conjugate addition of a silyl-cuprate reagent. 1994 Steroids pmid:7900169
Salen G et al. Comparative effects of lovastatin and chenodeoxycholic acid on plasma cholestanol levels and abnormal bile acid metabolism in cerebrotendinous xanthomatosis. 1994 Metab. Clin. Exp. pmid:8052141
Meiner V et al. Cerebrotendinous xanthomatosis: molecular diagnosis enables presymptomatic detection of a treatable disease. 1994 Neurology pmid:8309576
Lee KY et al. Electric field-induced concentration gradients in lipid monolayers. 1994 Science pmid:8303272
Takashima K et al. The hypocholesterolemic action of TA-7552 and its effects on cholesterol metabolism in the rat. 1994 Atherosclerosis pmid:7980699
Nakashima N et al. A point mutation in the bile acid biosynthetic enzyme sterol 27-hydroxylase in a family with cerebrotendinous xanthomatosis. 1994 J. Lipid Res. pmid:8006521
Miyabara Y et al. Estimation of urobilin as a fecal pollution indicator in the aquatic environment. 1994 Bull Environ Contam Toxicol pmid:8069079
Thomas MG et al. Effect of enteral feeding on intestinal epithelial proliferation and fecal bile acid profiles in the rat. 1993 May-Jun JPEN J Parenter Enteral Nutr pmid:7685051
Shine WE et al. Relation of cholesterol-stimulated Staphylococcus aureus growth to chronic blepharitis. 1993 Invest. Ophthalmol. Vis. Sci. pmid:8505210
Midtvedt AC and Midtvedt T Conversion of cholesterol to coprostanol by the intestinal microflora during the first two years of human life. 1993 J. Pediatr. Gastroenterol. Nutr. pmid:8229543
Pardo J et al. [Magnetic resonance of the brain and Achilles tendon in cerebrotendinous xanthomatosis]. 1993 Neurologia pmid:8240840
Nichols PD et al. Comparison of the abundance of the fecal sterol coprostanol and fecal bacterial groups in inner-shelf waters and sediments near Sydney, Australia. 1993 J. Chromatogr. pmid:8360300
Makarieva TN et al. Biosynthetic studies of marine lipids. 42. Biosynthesis of steroid and triterpenoid metabolites in the sea cucumber Eupentacta fraudatrix. 1993 Steroids pmid:8273112